CAJ | 학술논문

目的探讨原发性胆汁性肝硬化(PBC)与乙肝肝硬化(HBV-C)的失代偿期的临床特点、诊断与鉴别诊断要点、治疗重点等.方法对2004年1月至2011年8月确诊的失代偿期PBC患者16例作回顾性分析,并随机选择此时段内16例失代偿期HBV-C患者比较分析其临床表现、生化指标、影像学检查、治疗方法和治疗效果等.结果失代偿期PBC组以GLB、ALP、GGT及D-BIL升高明显,发生胆汁淤积较失代偿期HBV-C组明显.失代偿期PBC组红细胞、血红蛋白下降较失代偿期HBV-C组明显.失代偿期HBV-C组白蛋白下降更明显、PT延长更明显、PLT下降更明显.失代偿期PBC组自身免疫性指标常阳性.结论失代偿期的原发性PBC治疗应该以激素为主,失代偿期的HBV-C患者治疗仍然应该以抗病毒为主.失代偿期的HBV-C的预后略好于PBC.
목적 탐토원발성담즙성간경화(PBC)여을간간경화(HBV-C)적실대상기적림상특점、진단여감별진단요점、치료중점등.방법 대2004년1월지2011년8월학진적실대상기PBC환자16례작회고성분석,병수궤선택차시단내16례실대상기HBV-C환자비교분석기림상표현、생화지표、영상학검사、치료방법화치료효과등.결과 실대상기PBC조이GLB、ALP、GGT급D-BIL승고명현,발생담즙어적교실대상기HBV-C조명현.실대상기PBC조홍세포、혈홍단백하강교실대상기HBV-C조명현.실대상기HBV-C조백단백하강경명현、PT연장경명현、PLT하강경명현.실대상기PBC조자신면역성지표상양성.결론 실대상기적원발성PBC치료응해이격소위주,실대상기적HBV-C환자치료잉연응해이항병독위주.실대상기적HBV-C적예후략호우PBC.
Objective To analyze and study the features and key points of clinical diagnosis and therapy for primary biliary cirrhosis and hepatitis B cirrhosis in decompensation period.Methods The clinical manifestation,laboratory examination,iconography examination and therapeutic schedule,treatment effectiveness were analyzed by retrospective research method in 32 patients for the past 7.5 years.Results The GLB,ALP,GGT,D-BIL were increased,autoimmunity markers were positive in primary biliary cirrhosis patients in decompensation period.The ALP and PLT were decreased,PT was increased in hepatitis B cirrhosis patients.Conclusion The hormone therapy is important for primary biliary cirrhosis patients.The antivirus therapy is important for hepatitis B cirrhosis patients.The prognosis is better for hepatitis B cirrhosis than for primary biliary cirrhosis patients in decompensation period.