CAJ | 학술논문

目的探讨临床孤立综合征(CIS)的临床特点.方法回顾性分析17例临床孤立综合征的临床资料.结果共17例CIS患者,男5例,女12例,发病年龄10-67岁,急性起病,表现为截瘫伴尿潴留1例,肢体麻木5例,眩晕5例,面舌麻木感1例,眩晕伴面部麻木感1例,偏瘫、吞咽困难、言语不清、抽搐发作各1例.脑脊液白细胞增多4例,蛋白升高2例.MRI显示病灶位于大脑半球4例,小脑1例,脑干5例,脊髓7例,MRI显示病灶为T1WI低信号,T2WI、Flair呈高信号改变.结论 CIS是中枢神经系统首次发作的急性脱髓鞘病变,表现为运动、感觉、平衡功能受损的各种症状,以脑干和脊髓症状最常见,常规脑脊液检查改变不显著,MRI有助于确定病灶及临床诊断.CIS可能是多发性硬化的首次发作.
목적 탐토림상고립종합정(CIS)적림상특점.방법 회고성분석17례림상고립종합정적림상자료.결과 공17례CIS환자,남5례,녀12례,발병년령10-67세,급성기병,표현위절탄반뇨저류1례,지체마목5례,현훈5례,면설마목감1례,현훈반면부마목감1례,편탄、탄인곤난、언어불청、추휵발작각1례.뇌척액백세포증다4례,단백승고2례.MRI현시병조위우대뇌반구4례,소뇌1례,뇌간5례,척수7례,MRI현시병조위T1WI저신호,T2WI、Flair정고신호개변.결론 CIS시중추신경계통수차발작적급성탈수초병변,표현위운동、감각、평형공능수손적각충증상,이뇌간화척수증상최상견,상규뇌척액검사개변불현저,MRI유조우학정병조급림상진단.CIS가능시다발성경화적수차발작.
Objective To investigate clinical features of clinically isolated syndrome (CIS).Method Retrospectively studied the data of 17 cases of CIS.Results 17 patients included 5 male and 12 female,the age of onset of 10-67 years-old,with acute onset.1 case had paraplegia and urine retention,5 cases of numbness of limbs,5 cases of dizziness,2 cases of dizziness and facial numbness,1 case of hemiplegia,1 case of difficult swallowing,1 case of slurred speech,1 case of seizure.Cerebrospinal fluid showed 4 cases of leukocytosis and 2 cases of elevated protein.Magnetic resonance imaging (MRI) scan demonstrated demyelimative lesions in 4 cases located in cerebral hemisphere,1 case in cerebella,5 cases in brainstem,7 cases in spinal cord.The lesions were iso-or low T1WI,high T2WI and high FLAIR abnormal intensity.Conclusions CIS refers to the first acute episode of central nervous system demyelinative disease,involving disorders of movement,sensation and balance system,most commonly presenting in brainstem and spinal cord,without significant change in regular examination of CSF.MRI is the most helpful ancillary examination in lesion localization and clinical diagnosis.CIS may he the initial episode of multiple sclerosis.