中国医药
中國醫藥
중국의약
CHINA MEDICINE
2013年
9期
1251-1253
,共3页
白玉蓉%王熙然%李雪%葛爱青%王增武
白玉蓉%王熙然%李雪%葛愛青%王增武
백옥용%왕희연%리설%갈애청%왕증무
代谢综合征%非酒精性脂肪肝病%男性
代謝綜閤徵%非酒精性脂肪肝病%男性
대사종합정%비주정성지방간병%남성
Metabolic syndrome%Non-alcoholic fatty liver disease%Male
目的 探讨男性代谢综合征(MS)及其组分与非酒精性脂肪肝病(NAFLD)的关系.方法 用横断面研究的方法对1902例研究对象进行分析,根据NAFLD的诊断标准分为NAFLD组(778例)和对照组(1 124例).测定2组人群血压、BMI、TC、TG、LDL-C、HDL-C、空腹血糖和餐后2h血糖(2 h PG)、尿酸等指标并进行比较.结果 本组男性资料NAFLD的患病率为40.9％ (778/1902)；男性人群NAFLD组的BMI、高血压患病率、TG、空腹血糖及2hPG、LDL-C、尿酸水平均高于对照组[(25.6±2.1)kg/m2比(23.7± 5.6) kg/m2,33.8％ (263/778)比21.3％ (239/1124),(2.2±1.4) mmol/L比(1.4±0.8)mmol/L,(8.2±2.5) mmol/L比(7.2±1.7) mmol/L,(2.8±0.7)mmol/L比(2.7±0.7) mmol/L,(425±85) μmol./L比(336±100).μmol/L,P＜0.01],HDL-C水平低于对照组[(1.27±0.28) mmol/L比(1.44±0.34) mmol/L,P＜0.01]；Logistic回归分析显示TG、HDL-C、2 h PG、尿酸、BMI、高血压[OR值(95％ CI)分别为1.6559(1.253～2.026)、0.303(0.1526 ～0.603)、1.205(1.100 ～1.320)、1.003(1.001 ～ 1.005)、1.160(1.069～1.259)、1.69(1.084～2.634),均P＜0.05]是男性NAFLD的独立危险因素；与对照组相比,NAFLD组患者伴有2个以上MS组分者增多,差异有统计学意义(P＜0.05),男性MS在NAFLD组患病率明显高于对照组[41.7％(324/778)比13.7％(154/1124),P＜0.05]；男性MS患者发生NAFLD病的相对危险性是无MS患者的4.48倍(95％ CI,3.0786 ～6.5281).结论 男性人群NAFLD与多元代谢紊乱存在密切关系；MS组分TG、HDL-C、2 h PG、BMI、高血压是男性NAFLD病的独立危险因素.男性MS发生NAFLD的相对风险明显升高.
目的 探討男性代謝綜閤徵(MS)及其組分與非酒精性脂肪肝病(NAFLD)的關繫.方法 用橫斷麵研究的方法對1902例研究對象進行分析,根據NAFLD的診斷標準分為NAFLD組(778例)和對照組(1 124例).測定2組人群血壓、BMI、TC、TG、LDL-C、HDL-C、空腹血糖和餐後2h血糖(2 h PG)、尿痠等指標併進行比較.結果 本組男性資料NAFLD的患病率為40.9％ (778/1902)；男性人群NAFLD組的BMI、高血壓患病率、TG、空腹血糖及2hPG、LDL-C、尿痠水平均高于對照組[(25.6±2.1)kg/m2比(23.7± 5.6) kg/m2,33.8％ (263/778)比21.3％ (239/1124),(2.2±1.4) mmol/L比(1.4±0.8)mmol/L,(8.2±2.5) mmol/L比(7.2±1.7) mmol/L,(2.8±0.7)mmol/L比(2.7±0.7) mmol/L,(425±85) μmol./L比(336±100).μmol/L,P＜0.01],HDL-C水平低于對照組[(1.27±0.28) mmol/L比(1.44±0.34) mmol/L,P＜0.01]；Logistic迴歸分析顯示TG、HDL-C、2 h PG、尿痠、BMI、高血壓[OR值(95％ CI)分彆為1.6559(1.253～2.026)、0.303(0.1526 ～0.603)、1.205(1.100 ～1.320)、1.003(1.001 ～ 1.005)、1.160(1.069～1.259)、1.69(1.084～2.634),均P＜0.05]是男性NAFLD的獨立危險因素；與對照組相比,NAFLD組患者伴有2箇以上MS組分者增多,差異有統計學意義(P＜0.05),男性MS在NAFLD組患病率明顯高于對照組[41.7％(324/778)比13.7％(154/1124),P＜0.05]；男性MS患者髮生NAFLD病的相對危險性是無MS患者的4.48倍(95％ CI,3.0786 ～6.5281).結論 男性人群NAFLD與多元代謝紊亂存在密切關繫；MS組分TG、HDL-C、2 h PG、BMI、高血壓是男性NAFLD病的獨立危險因素.男性MS髮生NAFLD的相對風險明顯升高.
목적 탐토남성대사종합정(MS)급기조분여비주정성지방간병(NAFLD)적관계.방법 용횡단면연구적방법대1902례연구대상진행분석,근거NAFLD적진단표준분위NAFLD조(778례)화대조조(1 124례).측정2조인군혈압、BMI、TC、TG、LDL-C、HDL-C、공복혈당화찬후2h혈당(2 h PG)、뇨산등지표병진행비교.결과 본조남성자료NAFLD적환병솔위40.9％ (778/1902)；남성인군NAFLD조적BMI、고혈압환병솔、TG、공복혈당급2hPG、LDL-C、뇨산수평균고우대조조[(25.6±2.1)kg/m2비(23.7± 5.6) kg/m2,33.8％ (263/778)비21.3％ (239/1124),(2.2±1.4) mmol/L비(1.4±0.8)mmol/L,(8.2±2.5) mmol/L비(7.2±1.7) mmol/L,(2.8±0.7)mmol/L비(2.7±0.7) mmol/L,(425±85) μmol./L비(336±100).μmol/L,P＜0.01],HDL-C수평저우대조조[(1.27±0.28) mmol/L비(1.44±0.34) mmol/L,P＜0.01]；Logistic회귀분석현시TG、HDL-C、2 h PG、뇨산、BMI、고혈압[OR치(95％ CI)분별위1.6559(1.253～2.026)、0.303(0.1526 ～0.603)、1.205(1.100 ～1.320)、1.003(1.001 ～ 1.005)、1.160(1.069～1.259)、1.69(1.084～2.634),균P＜0.05]시남성NAFLD적독립위험인소；여대조조상비,NAFLD조환자반유2개이상MS조분자증다,차이유통계학의의(P＜0.05),남성MS재NAFLD조환병솔명현고우대조조[41.7％(324/778)비13.7％(154/1124),P＜0.05]；남성MS환자발생NAFLD병적상대위험성시무MS환자적4.48배(95％ CI,3.0786 ～6.5281).결론 남성인군NAFLD여다원대사문란존재밀절관계；MS조분TG、HDL-C、2 h PG、BMI、고혈압시남성NAFLD병적독립위험인소.남성MS발생NAFLD적상대풍험명현승고.
Objective To explore the association of non-alcoholic fatty liver disease (NAFLD) with metabolic syndrome(MS) and its components in male.Methods A cross-sectional study on 1902 subjects who were divided into NAFLD group(n =778) and control group(n =1124) by the diagnosis standants of NAFLD.Blood pressure,body mass index(BMI),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholestrol(LDL-C),high density lipoprotein cholestrol (HDL-C),fasting and postprandial plasma glucose (FPG,2 h lPG) as well as blood uric acid(UA) were measured.Results The prevalence of NAFLD in male group was 40.9％.BMI,the presence of hypertension,TG,FPG,2 h PG,UA in male group were significantly higher in NAFLD group than in control group[(25.6 ±2.1)kg/m2 vs (23.7 ±5.6) kg/m2,33.8％ (263/778) vs 21.3％ (239/1124),(2.2 ± 1.4) mmol/L vs (1.4 ± 0.8) mmol/L,(8.2 ± 2.5) nnol/L vs (7.2 ± 1.7) mmol/L,(2.8 ± 0.7) mmol/L vs (2.7 ± 0.7) mmol/L,(425 ± 85) p mol/L vs (336 ± 100) μmol/L,P ＜ 0.01].HDL-C was lower in NAFLD group [(1.27 ± 0.28) mmol/L vs (1.44 ± 0.34) rmtol/L,P ＜ 0.01].Logistic regression analysis showed that the level of TG,HDL-C,2 h PG,UA,BMI and the presence of hypertension[odds ratios(95％ CI)were 1.6559(1.253-2.026),0.303 (0.1526-0.603),1.205 (1.100-1.320),1.003 (1.001-1.005),1.160 (1.069-1.259),1.69 (1.084-2.634) respectively; all P ＜ 0.05] were independent risk factors of NAFLD group; Compared with the control group more than two numbers of MS components were increased in NAFLD group.The prevalence of MS in male group was higher than in control group (41.7 ％ vs 13.7 ％,P ＜ 0.05).The relative risk (RR =4.48,95 ％ CI 3.0786-6.5281) for NAFLD group significantly increased in patients with MS in male group.Conclusions In male groups NAFLD is closely related with cluster metabolic disorders.The level of TG,HlDL-C,2 h PG,BMI and the presence of hypertension are independent risk factors of NAFLD in male group.The RR for NAFLD significantly increase in patients with MS in male group.
