中华创伤杂志
中華創傷雜誌
중화창상잡지
Chinese Journal of Traumatology
2014年
5期
460-463
,共4页
朱永山%熊坤林%张玉龙%尹志勇
硃永山%熊坤林%張玉龍%尹誌勇
주영산%웅곤림%장옥룡%윤지용
脑损伤%弥漫性轴索损伤%弥散张量成像%兔
腦損傷%瀰漫性軸索損傷%瀰散張量成像%兔
뇌손상%미만성축색손상%미산장량성상%토
Brain injuries%Diffuse axonal injuries%Diffusion tensor imaging%Rabbits
目的 建立弥漫性轴索损伤(diffuse axonal injury,DAI)动物模型并探讨其早期影像学表现. 方法 选取25只成年新西兰大白兔按随机数字表法分为对照组(5只兔)、轻度DAI组和重度DAI组(6只),轻度DAI组又分3h(6只)、1 d(4只)及1周(4只)组,行弥散张量成像(diffusion tensor imaging,DTI)检查,并测量各项异性分数(fractional anisotropy,FA)、表观弥散系数(apparent diffusion coefficient,ADC)、轴向弥散度度(axial diffusivity,AD)及径向弥散度(radical diffusivity,RD). 结果 与对照组比较,重度DAI组大白兔脑白质FA明显升高(P＜0.01),ADC降低(P＜0.05),RD降低(P＜0.01),AD未见明显改变(P＞0.05).轻度DAI 3 h和1周组各项参数无明显改变,轻度DAI 1 d组FA明显升高(P＜0.01),RD降低(P＜0.05),ADC及AD无明显变化.结论 DTI是探索DAI发生及发展过程的一种敏感性成像方法,可为DAI早期诊断提供影像参考.
目的 建立瀰漫性軸索損傷(diffuse axonal injury,DAI)動物模型併探討其早期影像學錶現. 方法 選取25隻成年新西蘭大白兔按隨機數字錶法分為對照組(5隻兔)、輕度DAI組和重度DAI組(6隻),輕度DAI組又分3h(6隻)、1 d(4隻)及1週(4隻)組,行瀰散張量成像(diffusion tensor imaging,DTI)檢查,併測量各項異性分數(fractional anisotropy,FA)、錶觀瀰散繫數(apparent diffusion coefficient,ADC)、軸嚮瀰散度度(axial diffusivity,AD)及徑嚮瀰散度(radical diffusivity,RD). 結果 與對照組比較,重度DAI組大白兔腦白質FA明顯升高(P＜0.01),ADC降低(P＜0.05),RD降低(P＜0.01),AD未見明顯改變(P＞0.05).輕度DAI 3 h和1週組各項參數無明顯改變,輕度DAI 1 d組FA明顯升高(P＜0.01),RD降低(P＜0.05),ADC及AD無明顯變化.結論 DTI是探索DAI髮生及髮展過程的一種敏感性成像方法,可為DAI早期診斷提供影像參攷.
목적 건립미만성축색손상(diffuse axonal injury,DAI)동물모형병탐토기조기영상학표현. 방법 선취25지성년신서란대백토안수궤수자표법분위대조조(5지토)、경도DAI조화중도DAI조(6지),경도DAI조우분3h(6지)、1 d(4지)급1주(4지)조,행미산장량성상(diffusion tensor imaging,DTI)검사,병측량각항이성분수(fractional anisotropy,FA)、표관미산계수(apparent diffusion coefficient,ADC)、축향미산도도(axial diffusivity,AD)급경향미산도(radical diffusivity,RD). 결과 여대조조비교,중도DAI조대백토뇌백질FA명현승고(P＜0.01),ADC강저(P＜0.05),RD강저(P＜0.01),AD미견명현개변(P＞0.05).경도DAI 3 h화1주조각항삼수무명현개변,경도DAI 1 d조FA명현승고(P＜0.01),RD강저(P＜0.05),ADC급AD무명현변화.결론 DTI시탐색DAI발생급발전과정적일충민감성성상방법,가위DAI조기진단제공영상삼고.
Objective To establish animal models of diffuse axonal injury (DAI) and discuss the early functional MRI findings.Methods Twenty-five adult white rabbits were divided into control group (n =5),mild DAI group and severe DAI group (n =6) according to random number.Mild DAI group was subdivided into mild DAI 3 h (n =6),1 day (n =4) and 1 week (n =4) groups.Routine MRI and diffusion tensor imaging (DTI) were performed.Parameters measured were fractional anisotropy (FA),apparent diffusion coefficient (ADC),axial diffusivity (AD) and radical diffusivity (RD).Results Significantly increased FA (P＜0.01) and decreased ADC (P＜0.05) and RD (P＜0.01) were detected in severe DAI group compared to control group,but there was no significant variation in AD between the two groups (P ＞ 0.05).Each parameter remained almost unchanged in mild DAI 3 h group and mild DAI 1 week group,but FA was increased (P ＜ 0.01) and RD decreased (P ＜ 0.05) in mild DAI 1 day group,with no changes of ADC and AD.Conclusion DTI is a sensitive way to detect the occurrence and development of DAI and can provide referential images for early DAI diagnosis.
