CAJ | 학술논문

目的分析颅脑损伤后迟发性颅内血肿患者血液乳酸水平变化及其与迟发性颅内血肿的相关性. 方法选取2009年5月—2012年12月收治的急性颅脑损伤后迟发性颅内血肿患者48例,其中男32例,女16例,设为损伤组.选择同期进行健康体检无系统性疾病的健康人群50例作为对照组,其中男35例,女15例.患者于入院时、诊断为迟发性颅内血肿时、治疗7,14 d时测量静脉血乳酸值,并与对照组静脉血乳酸值进行比较. 结果入院时对照组血清乳酸值为(1.77 ±0.21) mmol/L,损伤组为(1.82±0.25) mmol/L(t=1.070,P＞0.05).诊断为迟发性血肿时,损伤组血清乳酸值为(3.32±0.89) mmol/L,治疗7d后升高至(3.74±1.16) mmol/L,治疗14 d后降至(1.89 ±0.75) mmol/L.其中诊断为迟发性血肿时及治疗7d时损伤组血清乳酸值与对照组比较差异有统计学意义(P＜0.05).各时相点乳酸水平与颅脑损伤具有相关性,但诊断为迟发性血肿时及治疗7d时相关系数较高,分别为0.986和0.989. 结论乳酸水平与颅脑损伤后迟发性颅内血肿具有关联性,并与病情的变化有关,可以作为临床判断迟发性颅内血肿病情发展的参考依据.
목적 분석로뇌손상후지발성로내혈종환자혈액유산수평변화급기여지발성로내혈종적상관성. 방법 선취2009년5월—2012년12월수치적급성로뇌손상후지발성로내혈종환자48례,기중남32례,녀16례,설위손상조.선택동기진행건강체검무계통성질병적건강인군50례작위대조조,기중남35례,녀15례.환자우입원시、진단위지발성로내혈종시、치료7,14 d시측량정맥혈유산치,병여대조조정맥혈유산치진행비교. 결과 입원시대조조혈청유산치위(1.77 ±0.21) mmol/L,손상조위(1.82±0.25) mmol/L(t=1.070,P＞0.05).진단위지발성혈종시,손상조혈청유산치위(3.32±0.89) mmol/L,치료7d후승고지(3.74±1.16) mmol/L,치료14 d후강지(1.89 ±0.75) mmol/L.기중진단위지발성혈종시급치료7d시손상조혈청유산치여대조조비교차이유통계학의의(P＜0.05).각시상점유산수평여로뇌손상구유상관성,단진단위지발성혈종시급치료7d시상관계수교고,분별위0.986화0.989. 결론 유산수평여로뇌손상후지발성로내혈종구유관련성,병여병정적변화유관,가이작위림상판단지발성로내혈종병정발전적삼고의거.
Objective To analyze changes in lactic acid level in patients with late-onset intracranial hematoma after craniocerebral injury and investigate their relativity.Methods Forty-eight patients with late-onset intracranial hematoma after craniocerebral injury treated in our hospital between May 2009 and December 2012 were enrolled as observation group.There were 32 males and 16 females.Moreover,50 cases checked up in our hospital during the same period were studied as health population controls,including 35 males and 15 females.Level of lactic acid was measured on admission,at the time of definite diagnosis as well as at days 7 and 14 after treatment and compared between groups.Results Level of lactic acid was (1.77 ±0.21) mmol/L in control group and (1.82 ± 0.25) mmol/L in observation group respectively on admission (t =1.070,P ＞ 0.05) ; Level of lactic acid was (3.32 ± 0.89) mmol/L in observation group at the time of definite diagnosis,which increased to (3.74 ± 1.16) mmol/L at days 7 after treatment and decreased to (1.89 ±0.75) mmol/L at days 14 after treatment.When diagnosed and treated for 7 days,level of lactic acid differed significantly between the two groups (P ＜ 0.05).Level of lactic acid related to craniocerebral injury at each time point,but higher correlation coefficient was observed at the time of definite diagnosis and 7 days after treatment with 0.986 and 0.989 respectively.Conclusion Level of lactic acid relates to late-onset intracranial hematoma after craniocerebral injury,which can be used as reference for progression of the disease.