中华创伤骨科杂志
中華創傷骨科雜誌
중화창상골과잡지
CHINESE JOURNAL OF ORTHOPAEDIC TRAUMA
2013年
4期
326-330
,共5页
段永宏%朱庆生%郭飞%李矛%蒋驰%朱锦宇
段永宏%硃慶生%郭飛%李矛%蔣馳%硃錦宇
단영굉%주경생%곽비%리모%장치%주금우
钽%假体和植入%骨和骨组织%组织相容性
鐽%假體和植入%骨和骨組織%組織相容性
단%가체화식입%골화골조직%조직상용성
Tantalum%Prostheses and implants%Bone and bones%Histocompatibility
目的 初步探讨钽涂层假体表面骨长入特点及其骨组织相容性. 方法 将60只雄性新西兰兔随机分为钽涂层组和钛涂层组(n=30),无菌条件下分别进行钽涂层假体与钛涂层假体股骨髁内植入术.分别于术后4、8、16周处死两组动物各10只,采用扫描电镜观察、能量色散X射线光谱仪(EDX)分析(分别取2个标本)、组织病理学观察(分别取8个标本)及骨组织形态计量学分析等方法对两组涂层假体表面附着组织的结构进行分析和量化. 结果 假体植入后4周,假体表面扫描电镜观察及EDX分析发现两组涂层假体表面均有骨组织附着,新生组织小梁结构清晰.组织病理学观察显示假体植入后两组涂层与周围新生骨组织结合紧密,涂层稳定无脱落,假体周围的骨量随假体植入时间逐渐增加.骨形态计量学分析结果显示:术后4、8、16周钽涂层组假体周围的骨量面积比值平均分别为29.92% ±3.92%、37.68% ±3.61%、42.94%±4.15%,钛涂层组平均分别为29.36%±3.39%、36.35%±3.03%、41.71%±3.86%,同一组内术后不同时间点两两比较差异均有统计学意义(P<0.05);同一时间点两组比较差异均无统计学意义(P>0.05).结论 随着植入时间的不断增加,钽涂层假体表面的成骨量不断增加;钽涂层假体具有良好的骨组织相容性及植入早期的稳定性.
目的 初步探討鐽塗層假體錶麵骨長入特點及其骨組織相容性. 方法 將60隻雄性新西蘭兔隨機分為鐽塗層組和鈦塗層組(n=30),無菌條件下分彆進行鐽塗層假體與鈦塗層假體股骨髁內植入術.分彆于術後4、8、16週處死兩組動物各10隻,採用掃描電鏡觀察、能量色散X射線光譜儀(EDX)分析(分彆取2箇標本)、組織病理學觀察(分彆取8箇標本)及骨組織形態計量學分析等方法對兩組塗層假體錶麵附著組織的結構進行分析和量化. 結果 假體植入後4週,假體錶麵掃描電鏡觀察及EDX分析髮現兩組塗層假體錶麵均有骨組織附著,新生組織小樑結構清晰.組織病理學觀察顯示假體植入後兩組塗層與週圍新生骨組織結閤緊密,塗層穩定無脫落,假體週圍的骨量隨假體植入時間逐漸增加.骨形態計量學分析結果顯示:術後4、8、16週鐽塗層組假體週圍的骨量麵積比值平均分彆為29.92% ±3.92%、37.68% ±3.61%、42.94%±4.15%,鈦塗層組平均分彆為29.36%±3.39%、36.35%±3.03%、41.71%±3.86%,同一組內術後不同時間點兩兩比較差異均有統計學意義(P<0.05);同一時間點兩組比較差異均無統計學意義(P>0.05).結論 隨著植入時間的不斷增加,鐽塗層假體錶麵的成骨量不斷增加;鐽塗層假體具有良好的骨組織相容性及植入早期的穩定性.
목적 초보탐토단도층가체표면골장입특점급기골조직상용성. 방법 장60지웅성신서란토수궤분위단도층조화태도층조(n=30),무균조건하분별진행단도층가체여태도층가체고골과내식입술.분별우술후4、8、16주처사량조동물각10지,채용소묘전경관찰、능량색산X사선광보의(EDX)분석(분별취2개표본)、조직병이학관찰(분별취8개표본)급골조직형태계량학분석등방법대량조도층가체표면부착조직적결구진행분석화양화. 결과 가체식입후4주,가체표면소묘전경관찰급EDX분석발현량조도층가체표면균유골조직부착,신생조직소량결구청석.조직병이학관찰현시가체식입후량조도층여주위신생골조직결합긴밀,도층은정무탈락,가체주위적골량수가체식입시간축점증가.골형태계량학분석결과현시:술후4、8、16주단도층조가체주위적골량면적비치평균분별위29.92% ±3.92%、37.68% ±3.61%、42.94%±4.15%,태도층조평균분별위29.36%±3.39%、36.35%±3.03%、41.71%±3.86%,동일조내술후불동시간점량량비교차이균유통계학의의(P<0.05);동일시간점량조비교차이균무통계학의의(P>0.05).결론 수착식입시간적불단증가,단도층가체표면적성골량불단증가;단도층가체구유량호적골조직상용성급식입조기적은정성.
Objective To characterize bone biocompatibility and periprosthetic osteogenesis of Ta-coated prosthesis.Methods Sixty male New Zealand rabbits were randomized into a Ta-coated group (n =30) and a titanium (Ti)-coated group (n =30).Ta-coated and Ti-coated prostheses were respectively implanted into the femoral condyles of the animals in the 2 groups.Ten rabbits in each group were sacrificed respectively at 4,8,16 weeks postoperation.Scanning electron microscopy (SEM) (2 samples),energy-dispersive X-ray spectroscopy (EDX) (2 samples),histopathological observation (8 samples),histomorphometric analysis were employed to evaluate the volume of bone growth on the prosthetic surface and surrounding the prostheses in both groups.Results At 4 weeks after implantation in both groups,SEM and EDX found attachment of bony tissue on the coating surface of prostheses and clear trabecular structure of the newly growing tissue.Histopathological observation demonstrated in both groups tight adherence of the new bony tissue to the prosthetic coating,stable coating without exfoliation and increased volume of periprosthetic osteogenesis with the increased implantation time.Bone morphometric analysis showed that the proportions of periprosthetic osteogenesis area at 4,8 and 16 weeks after implantation were respectively 29.92% ± 3.92%,37.68% ± 3.61% and 42.94% ±4.15% in the Ta-coated group and respectively 29.36% ±3.39%,36.35% ± 3.03% and 4 1.71% ± 3.86% in the Ti-coated group.There were significant differences between any 2 time points within the same group (P < 0.05) but not between the 2 groups at the same time point (P > 0.05).Conclusions The periprosthetic osteogenesis of Ta-coated prostheses increases with the time of implantation.Ta-coated prostheses have good bone biocompatibility and demonstrate postsurgical stability at the early stage after implantation.