CAJ | 학술논문

目的探讨新型β钛合金半针低弹性模量外固定系统对实验犬胫骨骨折愈合的影响.方法选取健康杂种犬20只,雌雄不限,建立实验犬胫骨骨折模型并随机分成2组(n=10),分别采用新型β钛合金Ti-24Nb-4Zr-7.9Sn(低弹性模量组,弹性模量为42 GPa)和α+β钛合金Ti-6Al-4V(高弹性模量组,弹性模量为110 GPa)制备外固定半针,并连接其他相同部件,构建低弹性模量及高弹性模量单边外固定系统固定胫骨骨折.运用Micro-CT影像分析技术及骨强度生物力学试验分析两组实验犬胫骨骨折愈合的情况. 结果术后2个月两组实验犬胫骨骨折均获愈合.与高弹性模量组相比,低弹性模量组骨密度更大、骨小梁间隙更小、骨小梁厚度更大、骨小梁数目更多,两组比较差异均有统计学意义(P＜0.05),因此,低弹性模量组愈合骨数量及质量均优于高弹性模量组.骨强度生物力学试验证实低弹性模量组愈合骨能够承载的力学负荷较高弹性模量组更大,差异有统计学意义(P＜0.05). 结论与高弹性模量外固定系统比较,新型β钛合金半针低弹性模量外固定系统固定胫骨骨折更有利于骨折的愈合和坚强固定,可更早拆除外固定系统.
목적 탐토신형β태합금반침저탄성모량외고정계통대실험견경골골절유합적영향.방법 선취건강잡충견20지,자웅불한,건립실험견경골골절모형병수궤분성2조(n=10),분별채용신형β태합금Ti-24Nb-4Zr-7.9Sn(저탄성모량조,탄성모량위42 GPa)화α+β태합금Ti-6Al-4V(고탄성모량조,탄성모량위110 GPa)제비외고정반침,병련접기타상동부건,구건저탄성모량급고탄성모량단변외고정계통고정경골골절.운용Micro-CT영상분석기술급골강도생물역학시험분석량조실험견경골골절유합적정황. 결과 술후2개월량조실험견경골골절균획유합.여고탄성모량조상비,저탄성모량조골밀도경대、골소량간극경소、골소량후도경대、골소량수목경다,량조비교차이균유통계학의의(P＜0.05),인차,저탄성모량조유합골수량급질량균우우고탄성모량조.골강도생물역학시험증실저탄성모량조유합골능구승재적역학부하교고탄성모량조경대,차이유통계학의의(P＜0.05). 결론 여고탄성모량외고정계통비교,신형β태합금반침저탄성모량외고정계통고정경골골절경유리우골절적유합화견강고정,가경조탁제외고정계통.
Objective To explore the effect of the external fixation system of low elastic modulus low elastic modulus with halfpins made of β titanium alloy on bone healing in canine models of tibial fracture.Methods Twenty healthy mongrels were used to establish canine models of tibial fracture for this experiment.Next they were randomized into 2 even groups (10 each).The fractures in the 2 groups were subjected respectively to external fixation of low versus high elastic modulus.The external fixation system of low elastic modulus contained halfpins made of β titanium alloy Ti-24Nb-4Zr-7.9Sn (G =42 GPa) while that of high elastic modulus contained halfpins made of α + β titanium alloy Ti-6Al-4V (G =110 GPa).The other components of the 2 external systems were the same.The bone healing was observed and compared between the 2 groups using Micro-CT and biomechanical analyses at 2 months after operation.Results After 2-month treatment,the fractures healed in both groups.Compared with the high elastic modulus group,the low elastic modulus group had significantly greater bone mineral density,significantly smaller trabecular spacing (Tb.Sp),significantly greater trabecular thickness (Tb.Th),and significantly greater trabecular number (Tb.N) (all P ＜0.05).The newly healed bone in the low elastic modulus group was superior to that in the high elastic modulus group in both quantity and quality,and the former had significantly greater biomechanical strength than the latter (P ＜ 0.05).Conclusion External fixation system of low elastic modulus low elastic modulus with halfpins made of β titanium alloy can reduce the effect of stress-shielding to achieve more rigid fixation which mav lead to better bone healing,and consequently earlier removal of external fixation system as well.