CAJ | 학술논문

目的探讨三维斑点追踪显像(3D-STI技术)评价急性心肌梗死犬左室局部收缩功能的应用价值.方法对24只成年比格犬左冠状动脉前降支(LAD)结扎前、结扎180 min后分别行二维斑点追踪显像(2DD-STI)及3D-STI检查.实验结束后,行心肌氯化三苯基四氮唑(TTC)染色,确定梗死心肌节段和非梗死心肌节段,比较两者间纵向收缩期峰值应变(LS)的大小及运用2D-STI和3D-STI的耗时.结果 20只犬成功建立急性心肌梗死模型.结扎后梗死心肌节段2D-STI和3D-STI的LS均较结扎前的基础状态明显减低(P＜0.01),运用3D-STI存储和分析图像所用时间明显短于2D-STI(P＜0.01).3D-STI参数的ROC曲线下面积比2D-STI大.以3D-STI的LS值-12.56％为截点诊断急性心肌梗死的敏感性77.9％,特异性88.2％.结论 3D-STI可准确评价节段性室壁运动异常,是一种方便、准确的评价急性心肌梗死的新方法.
목적 탐토삼유반점추종현상(3D-STI기술)평개급성심기경사견좌실국부수축공능적응용개치.방법 대24지성년비격견좌관상동맥전강지(LAD)결찰전、결찰180 min후분별행이유반점추종현상(2DD-STI)급3D-STI검사.실험결속후,행심기록화삼분기사담서(TTC)염색,학정경사심기절단화비경사심기절단,비교량자간종향수축기봉치응변(LS)적대소급운용2D-STI화3D-STI적모시.결과 20지견성공건립급성심기경사모형.결찰후경사심기절단2D-STI화3D-STI적LS균교결찰전적기출상태명현감저(P＜0.01),운용3D-STI존저화분석도상소용시간명현단우2D-STI(P＜0.01).3D-STI삼수적ROC곡선하면적비2D-STI대.이3D-STI적LS치-12.56％위절점진단급성심기경사적민감성77.9％,특이성88.2％.결론 3D-STI가준학평개절단성실벽운동이상,시일충방편、준학적평개급성심기경사적신방법.
Objective To investigate the value of three-dimensional speckle tracking imaging(3D-STI) in assessment of left ventricular regional systolic function in acute myocardial infarction model of dogs.Methods Left anterior descending (LAD) coronary artery was ligated in 24 adult beagle dogs.Longitudinal strain(LS) of every left ventricular segment before ligation and 180 min after ligation,and the time for acquisition and analysis were obtained using two-dimensional speckle tracking imaging (2D-STI) and 3D-STI.After the experiment,left ventricular myocardium were determined by TTC staining and divided into two groups:infarcted myocardial segments and non-infarcted myocardial segments.Results Experimental model of acute myocardial infarction was established successfully in 20 dogs.After ligation,both LS of 2D-STI and 3D-STI in infarcted myocardial segments were significantly lower (P ＜ 0.01).The time for acquisition and analysis of the images by 3D-STI were significantly shorter than that by 2D-STI (P ＜0.01).The area under the ROC curve of 3D-STI was larger than that of 2D-STI.A cut-off value of-12.56％ for LS of the 3D-STI had 77.9％ sensitivity and 88.2％ specificity in predicting acute myocardial infarction.Conclusions 3D-STI is a convenient,accurate method for evaluating left ventricular regional systolic function.