中华耳鼻咽喉头颈外科杂志
中華耳鼻嚥喉頭頸外科雜誌
중화이비인후두경외과잡지
CHINESE JOURNAL OF OTORHINOLARYNGOLOGY HEAD AND NECK SURGERY
2013年
7期
549-554
,共6页
陈伯亚%龙自铭%黄燕君%曾坚明
陳伯亞%龍自銘%黃燕君%曾堅明
진백아%룡자명%황연군%증견명
鼻炎,变应性,常年性%脱敏法,免疫%投药,舌下%变应原%治疗结果
鼻炎,變應性,常年性%脫敏法,免疫%投藥,舌下%變應原%治療結果
비염,변응성,상년성%탈민법,면역%투약,설하%변응원%치료결과
Rhinitis,allergic,perennial%Desensitization,immunologic%Administration,sublingual%Allergens%Treatment outcome
目的 评估标准化粉尘螨滴剂舌下特异性免疫治疗(sublingual immunotherapy,SLIT)对单一过敏和多重过敏的变应性鼻炎(allergic rhinitis,AR)患者的疗效.方法 回顾性分析69例接受粉尘螨滴剂SLIT治疗1.5 ～2.0年且随访资料完整的AR患者资料.根据皮肤点刺试验结果将患者分为单一过敏组和多重过敏组.在治疗前、治疗半年、1.0年和1.5 ～2.0年后,评估两组患者的鼻部症状评分(total nasal symptoms score,TNSS)和药物评分(total medication score,TMS)的变化.以SPSS 20.0统计软件进行数据分析.结果 SLIT半年和1.0年时,单一过敏组患者的TNSS(2.00[1.00；3.00]、0.00[0.00；1.00]分)低于多重过敏组(3.00[2.00；4.00]、2.00[0.00；3.00]分),差异有统计学意义(Z值为-2.851、-2.590,P均＜0.05)；SLIT治疗1.5 ～2.0年后,单一过敏组患者(0.00[0.00；1.00]分)与多重过敏组患者(0.00[0.00；2.00]分)的TNSS差异无统计学意义(Z=-1.461,P＞0.05).SLIT治疗半年、1.0年、1.5～2.0年后,单一过敏组和多重过敏组的TMS差异无统计学意义(Z值为-0.777、-0.944、-0.907,P均＞0.05).结论 舌下含服粉尘螨滴剂对单一过敏和多重过敏(含尘螨)的AR患者均有疗效.经过1.5 ～2.0年的SLIT治疗后,多重过敏患者也可以达到单一尘螨过敏AR患者的治疗效果.
目的 評估標準化粉塵螨滴劑舌下特異性免疫治療(sublingual immunotherapy,SLIT)對單一過敏和多重過敏的變應性鼻炎(allergic rhinitis,AR)患者的療效.方法 迴顧性分析69例接受粉塵螨滴劑SLIT治療1.5 ～2.0年且隨訪資料完整的AR患者資料.根據皮膚點刺試驗結果將患者分為單一過敏組和多重過敏組.在治療前、治療半年、1.0年和1.5 ～2.0年後,評估兩組患者的鼻部癥狀評分(total nasal symptoms score,TNSS)和藥物評分(total medication score,TMS)的變化.以SPSS 20.0統計軟件進行數據分析.結果 SLIT半年和1.0年時,單一過敏組患者的TNSS(2.00[1.00；3.00]、0.00[0.00；1.00]分)低于多重過敏組(3.00[2.00；4.00]、2.00[0.00；3.00]分),差異有統計學意義(Z值為-2.851、-2.590,P均＜0.05)；SLIT治療1.5 ～2.0年後,單一過敏組患者(0.00[0.00；1.00]分)與多重過敏組患者(0.00[0.00；2.00]分)的TNSS差異無統計學意義(Z=-1.461,P＞0.05).SLIT治療半年、1.0年、1.5～2.0年後,單一過敏組和多重過敏組的TMS差異無統計學意義(Z值為-0.777、-0.944、-0.907,P均＞0.05).結論 舌下含服粉塵螨滴劑對單一過敏和多重過敏(含塵螨)的AR患者均有療效.經過1.5 ～2.0年的SLIT治療後,多重過敏患者也可以達到單一塵螨過敏AR患者的治療效果.
목적 평고표준화분진만적제설하특이성면역치료(sublingual immunotherapy,SLIT)대단일과민화다중과민적변응성비염(allergic rhinitis,AR)환자적료효.방법 회고성분석69례접수분진만적제SLIT치료1.5 ～2.0년차수방자료완정적AR환자자료.근거피부점자시험결과장환자분위단일과민조화다중과민조.재치료전、치료반년、1.0년화1.5 ～2.0년후,평고량조환자적비부증상평분(total nasal symptoms score,TNSS)화약물평분(total medication score,TMS)적변화.이SPSS 20.0통계연건진행수거분석.결과 SLIT반년화1.0년시,단일과민조환자적TNSS(2.00[1.00；3.00]、0.00[0.00；1.00]분)저우다중과민조(3.00[2.00；4.00]、2.00[0.00；3.00]분),차이유통계학의의(Z치위-2.851、-2.590,P균＜0.05)；SLIT치료1.5 ～2.0년후,단일과민조환자(0.00[0.00；1.00]분)여다중과민조환자(0.00[0.00；2.00]분)적TNSS차이무통계학의의(Z=-1.461,P＞0.05).SLIT치료반년、1.0년、1.5～2.0년후,단일과민조화다중과민조적TMS차이무통계학의의(Z치위-0.777、-0.944、-0.907,P균＞0.05).결론 설하함복분진만적제대단일과민화다중과민(함진만)적AR환자균유료효.경과1.5 ～2.0년적SLIT치료후,다중과민환자야가이체도단일진만과민AR환자적치료효과.
Objective To compare the efficacy of sublingual immunotherapy (SLIT) with standardized Dermatophagoides farinae drops in monosensitized and polysensitized patients with allergic rhinitis.Methods The efficacy of SLIT in 69 patients who were sensitized to house dust mites and treated with Dermatophagoides farinae drops for 1.5-2.0 year with complete clinical data were analyzed retrospectively.These patients had been divided into the monoallergen sensitized group and polyallergen sensitized group according to the results of skin prick tests.The total medication score (TMS) and the total nasal symptoms score (TNSS) were evaluated before and half an year,1.0 year and 1.5-2.0 years after SLIT treatment.Results After SLIT treatment for half an year,the TNSS in the monoallergen sensitized group (2.00 [1.00; 3.00]) was significantly lower than that in the polyallergen sensitized group (3.00 [2.00 ;4.00],Z =-2.851,P ＜ 0.05),this significant difference of TNSS between the two groups was also found after SLIT treatment for 1.0 year (0.00 [0.00 ; 1.00],2.00 [0.00 ; 3.00],Z =-2.590,P ＜0.05).Whereas,there was no significant difference between the two groups after 1.5-2.0 years'treatment refer to the TNSS (0.00 [0.00 ; 1.00],0.00 [0.00 ; 2.00],Z =-1.461,P ＞ 0.05).Half an year,1.0 year and 1.5-2.0 years after SLIT treatment,the TMS in both groups reduced significantly,with no significant difference between two groups (Z value was-0.777,-0.944,-0.907,all P ＞ 0.05).Conclusions SLIT with Dermatophagoides farinae drops is effective in monosensitized and polysensitized patients with allergic rhinitis.And equivalent efficacy could be achieved after 1.5-2.0 years.
