目的 建立Sniffin' Sticks检查的中国人正常参考值,探讨其在我国临床应用的可行性.方法 2007年至2013年于首都医科大学附属北京同仁医院体检科,任意选取健康志愿者105例作为健康对照组,任意选取同期该院耳鼻咽喉头颈外科门诊嗅觉障碍患者165例作为试验组,其中嗅觉功能减退组92例,嗅觉功能丧失组73例.对270例受试者又分别分为青年组(＜ 35岁)、中年组(～55岁)和老年组(＞55岁)3个亚组,分别采用Sniffin' Sticks和T&T方法进行嗅觉功能检查.以SPSS12.0统计软件对数据结果进行分析.结果 Sniffin' Sticks正常参考值是:青年组TDI值(气味阈值T、气味辨别阈值D和气味识别阈值I,三项得分之和)＞30.12,中年组TDI值＞27.37,老年组TDI值＞20.43；健康对照组TDI平均((x-)±s)值为32.12±3.95,嗅觉功能减退组TDI平均值17.52±10.37,嗅觉功能丧失组TDI平均值3.56±3.49.嗅觉功能减退和嗅觉功能丧失组和健康对照组按照青年、中年和老年各亚组分别比较,TDI值、阈值、辨别阈和识别阈差异均有统计学意义(青年组:FTDI=125.136,FT=49.454,FD=89.037,FI=39.888,P值均为0.000;中年组:FTDI=190.240,FT=128.374,FD=174.122,FI=178.945,P值均为0.000；老年组:FTDI=72.992,FT=26.599,FD=77.119,FI=88.107,P值均为0.000).T&T嗅觉识别阈结果显示,健康对照组平均值为-1.00±0.98,嗅觉功能减退组为2.27 ±2.01,嗅觉功能丧失组为5.89±0.14.嗅觉功能减退和丧失组与健康对照组按照青年、中年和老年各亚组分组比较差异均有统计学意义(F青年=158.144,F中年=247.695,F老年=70.579,P值均为0.000).Sniffin' Sticks检查结果中的TDI值与T＆T嗅觉识别阈值呈负相关(r=-0.927,P＜0.01).T&T识别阈值与Sniffin' Sticks阈值呈负相关(rT=-0.846,P＜0.01)；与辨别阈呈负相关(rD=-0.908,P＜0.01)；与识别阈呈负相关(rI=-0.864,P＜0.01).结论 Sniffin' Sticks嗅觉检测方法均能很好地区分嗅觉功能正常、减退和丧失,其测试结果与T&T测试存在一致性,Sniffin' Sticks方法能多方面评价受试者的嗅觉功能状态,可以在中国人群中使用.
目的 建立Sniffin' Sticks檢查的中國人正常參攷值,探討其在我國臨床應用的可行性.方法 2007年至2013年于首都醫科大學附屬北京同仁醫院體檢科,任意選取健康誌願者105例作為健康對照組,任意選取同期該院耳鼻嚥喉頭頸外科門診嗅覺障礙患者165例作為試驗組,其中嗅覺功能減退組92例,嗅覺功能喪失組73例.對270例受試者又分彆分為青年組(＜ 35歲)、中年組(～55歲)和老年組(＞55歲)3箇亞組,分彆採用Sniffin' Sticks和T&T方法進行嗅覺功能檢查.以SPSS12.0統計軟件對數據結果進行分析.結果 Sniffin' Sticks正常參攷值是:青年組TDI值(氣味閾值T、氣味辨彆閾值D和氣味識彆閾值I,三項得分之和)＞30.12,中年組TDI值＞27.37,老年組TDI值＞20.43；健康對照組TDI平均((x-)±s)值為32.12±3.95,嗅覺功能減退組TDI平均值17.52±10.37,嗅覺功能喪失組TDI平均值3.56±3.49.嗅覺功能減退和嗅覺功能喪失組和健康對照組按照青年、中年和老年各亞組分彆比較,TDI值、閾值、辨彆閾和識彆閾差異均有統計學意義(青年組:FTDI=125.136,FT=49.454,FD=89.037,FI=39.888,P值均為0.000;中年組:FTDI=190.240,FT=128.374,FD=174.122,FI=178.945,P值均為0.000；老年組:FTDI=72.992,FT=26.599,FD=77.119,FI=88.107,P值均為0.000).T&T嗅覺識彆閾結果顯示,健康對照組平均值為-1.00±0.98,嗅覺功能減退組為2.27 ±2.01,嗅覺功能喪失組為5.89±0.14.嗅覺功能減退和喪失組與健康對照組按照青年、中年和老年各亞組分組比較差異均有統計學意義(F青年=158.144,F中年=247.695,F老年=70.579,P值均為0.000).Sniffin' Sticks檢查結果中的TDI值與T＆T嗅覺識彆閾值呈負相關(r=-0.927,P＜0.01).T&T識彆閾值與Sniffin' Sticks閾值呈負相關(rT=-0.846,P＜0.01)；與辨彆閾呈負相關(rD=-0.908,P＜0.01)；與識彆閾呈負相關(rI=-0.864,P＜0.01).結論 Sniffin' Sticks嗅覺檢測方法均能很好地區分嗅覺功能正常、減退和喪失,其測試結果與T&T測試存在一緻性,Sniffin' Sticks方法能多方麵評價受試者的嗅覺功能狀態,可以在中國人群中使用.
목적 건립Sniffin' Sticks검사적중국인정상삼고치,탐토기재아국림상응용적가행성.방법 2007년지2013년우수도의과대학부속북경동인의원체검과,임의선취건강지원자105례작위건강대조조,임의선취동기해원이비인후두경외과문진후각장애환자165례작위시험조,기중후각공능감퇴조92례,후각공능상실조73례.대270례수시자우분별분위청년조(＜ 35세)、중년조(～55세)화노년조(＞55세)3개아조,분별채용Sniffin' Sticks화T&T방법진행후각공능검사.이SPSS12.0통계연건대수거결과진행분석.결과 Sniffin' Sticks정상삼고치시:청년조TDI치(기미역치T、기미변별역치D화기미식별역치I,삼항득분지화)＞30.12,중년조TDI치＞27.37,노년조TDI치＞20.43；건강대조조TDI평균((x-)±s)치위32.12±3.95,후각공능감퇴조TDI평균치17.52±10.37,후각공능상실조TDI평균치3.56±3.49.후각공능감퇴화후각공능상실조화건강대조조안조청년、중년화노년각아조분별비교,TDI치、역치、변별역화식별역차이균유통계학의의(청년조:FTDI=125.136,FT=49.454,FD=89.037,FI=39.888,P치균위0.000;중년조:FTDI=190.240,FT=128.374,FD=174.122,FI=178.945,P치균위0.000；노년조:FTDI=72.992,FT=26.599,FD=77.119,FI=88.107,P치균위0.000).T&T후각식별역결과현시,건강대조조평균치위-1.00±0.98,후각공능감퇴조위2.27 ±2.01,후각공능상실조위5.89±0.14.후각공능감퇴화상실조여건강대조조안조청년、중년화노년각아조분조비교차이균유통계학의의(F청년=158.144,F중년=247.695,F노년=70.579,P치균위0.000).Sniffin' Sticks검사결과중적TDI치여T＆T후각식별역치정부상관(r=-0.927,P＜0.01).T&T식별역치여Sniffin' Sticks역치정부상관(rT=-0.846,P＜0.01)；여변별역정부상관(rD=-0.908,P＜0.01)；여식별역정부상관(rI=-0.864,P＜0.01).결론 Sniffin' Sticks후각검측방법균능흔호지구분후각공능정상、감퇴화상실,기측시결과여T&T측시존재일치성,Sniffin' Sticks방법능다방면평개수시자적후각공능상태,가이재중국인군중사용.
Objectives To establish the normal value of Sniffin' Sticks test in Chinese population and to explore it's clinical application in China.Methods One hundred and five healthy volunteers were choosen from the department of physical examination of Beijing Tongren Hospital between 2007 and 2013.Another 165 patients complained of abnormal olfactory function were obtained from the outpatient clinic of the department of otorhinolaryngology head and neck surgery in the same period and were divided into two groups:92 in hyposmia and 73 in functional anosmia group.The 270 subjects were divided into 3 subgroups:younger group(＜35 years of age),middle-age group(35-55 years of age) and older group(＞55 years of age).The olfactory functions were examined with Sniffin' Sticks test and T&T test,respectively.All analyses were performed using SPSS 12.0 software.Results For the normal value of Sniffin' Sticks test,TDI score was ＞30.12 for younger group,＞27.37 for middle-age group and ＞20.43 for older group; the mean TDI score was 32.12 ± 3.95 for healthy group,17.52 ± 10.37 for hyposmia and 3.56 ± 3.49 for functional anosmia group; the differences in TDI score,olfactory threshold,discrimination threshold and identification threshold between healthy group and olfactory dysfunction group with different ages had statistical significance (Younger group:FTDI =125.136,P =0.000 ; FT =49.454,P =0.000 ; FD =89.037,P =0.000 ; FI =39.888,P =0.000; Middle-age group:FTDI =190.240,P =0.000;FT =128.374,P =0.000;FD =174.122,P =0.000 ; FI =178.945,P =0.000 ; Older group:FTDI =72.992,P =0.000 ; FT =26.599,P =0.000 ; FD =77.119,P =0.000 ; FI =88.107,P =0.000,respectively).The mean T&T value was-1.00 ± 0.98 for healthy group,2.27 ±2.01 for hyposmia and 5.89 ±0.14 for functional anosmia group.T&T score between healthy group and olfactory dysfunction group with different ages had statistical significance (Fyounger =158.144,P =0.000; Fmiddle-age =247.695,P =0.000; Folder =70.579,P =0.000,respectively).TDI score of the Sniffin' Sticks test result was correlated with T&T value (r =-0.927,P ＜ 0.01) ; T&T threshold was correlated with the olfactory threshold,discrimination threshold and identification threshold of Sniffin' Sticks test (rT =-0.846,P ＜0.01,rD =-0.908 P ＜0.01,rI =-0.864,P ＜0.01,respectively).Conclusions Sniffin' Sticks test and T&T olfactometry are able to differentiate normosmia from hyposmia and anosmia with high reliability and consistency in test results.Sniffin' Sticks test can assess subject's olfactory function status more thoroughly and is suitable for application in Chinese population.
