CAJ | 학술논문

目的利用整体骨炎评分系统,分析慢性鼻-鼻窦炎(chronic sinusitis,CRS)骨炎的严重程度与不同影响因素的相关性.方法选择334例准备行内镜鼻窦手术的CRS伴或不伴鼻息肉(CRS with/without nasal polyps,CRSwNP/CRSsNP)的患者,通过PHILIPS MxLiteView软件分析术前鼻窦CT,利用整体骨炎评分系统进行评分和分级,分析CRS整体骨炎评分与性别、年龄、吸烟、CRS病程、哮喘、皮肤点刺试验(skin prick test,SPT)、阿司匹林哮喘(aspirin sensitive asthma,ASA)、鼻息肉、Lund-Mackay评分、Lund-Kennedy评分、鼻内镜手术次数之间的相关性,归纳总结出代表CRS骨炎严重程度的标志性因素.结果 CRS骨炎的严重程度与性别(P =0.542)、年龄(P=O.092)、吸烟(P=0.695)、SPT(P =0.182)之间没有相关性.多元线性回归分析显示,CRS骨炎严重程度与鼻息肉、ASA、哮喘无相关性(P值均＞0.05),而与鼻内镜手术次数、Lund-Mackay评分、Lund-Kennedy评分、CRS病程之间具有相关性(r值分别为0.528、0.170、0.193、0.146,P值均＜0.01).结论骨炎是导致难治性鼻-鼻窦炎的一个重要原因,鼻内镜手术次数可以作为反映骨炎严重程度的一个重要标志.
목적 이용정체골염평분계통,분석만성비-비두염(chronic sinusitis,CRS)골염적엄중정도여불동영향인소적상관성.방법 선택334례준비행내경비두수술적CRS반혹불반비식육(CRS with/without nasal polyps,CRSwNP/CRSsNP)적환자,통과PHILIPS MxLiteView연건분석술전비두CT,이용정체골염평분계통진행평분화분급,분석CRS정체골염평분여성별、년령、흡연、CRS병정、효천、피부점자시험(skin prick test,SPT)、아사필림효천(aspirin sensitive asthma,ASA)、비식육、Lund-Mackay평분、Lund-Kennedy평분、비내경수술차수지간적상관성,귀납총결출대표CRS골염엄중정도적표지성인소.결과 CRS골염적엄중정도여성별(P =0.542)、년령(P=O.092)、흡연(P=0.695)、SPT(P =0.182)지간몰유상관성.다원선성회귀분석현시,CRS골염엄중정도여비식육、ASA、효천무상관성(P치균＞0.05),이여비내경수술차수、Lund-Mackay평분、Lund-Kennedy평분、CRS병정지간구유상관성(r치분별위0.528、0.170、0.193、0.146,P치균＜0.01).결론 골염시도치난치성비-비두염적일개중요원인,비내경수술차수가이작위반영골염엄중정도적일개중요표지.
Objective To analyse the severity of chronic sinusitis osteitis and the correlation factors by global osteitis scoring scale (GOSS).Methods Three hundreds and thirty-four patients with chronic rhinosinusitis with or without nasal polyps(CRSwNP/CRSsNP) were enrolled prospectively in a large tertiary referral center.Preoperative sinus CT was analysed by PHILIPS MxLiteView software.Using grading and classification of GOSS,the association between GOSS and gender,age,smoking,CRS course,asthma,skin prick test (SPT),aspirin sensitive asthma (ASA),nasal polyp,Lund-Mackay,Lund-Kennedy,the number of previous sinus surgeries was examined.Finally a marker factors of severity of CRS osteitis was concluded.Results There was no association between CRS osteitis and gender (P =0.542),age (P =0.092),smoking(P =0.695),SPT(P =0.182).Multiple liner regression analysis showed that there was no association between CRS osteitis and nasal polyps,ASA and asthma (all P ＞ 0.05).The severity of CRS osteitis was correlated with the number of previous sinus surgeries,Lund-Mackay scores,Lund-Kennedy scores,CRS course (r1 =0.528,r2 =0.170,r3 =0.193,r4 =0.146,respectively,all P ＜ 0.01).Conclusions Osteitis is an important reason of refractory chronic rhinosinusitis.The number of previous sinus surgeries can be used as an important marker for the severity of the osteitis.