中华耳鼻咽喉头颈外科杂志
中華耳鼻嚥喉頭頸外科雜誌
중화이비인후두경외과잡지
CHINESE JOURNAL OF OTORHINOLARYNGOLOGY HEAD AND NECK SURGERY
2014年
4期
277-282
,共6页
戴伟利%葛文彤%张杰%张亚梅
戴偉利%葛文彤%張傑%張亞梅
대위리%갈문동%장걸%장아매
儿童%鼻炎,变应性,常年性%过敏反应%危险因素
兒童%鼻炎,變應性,常年性%過敏反應%危險因素
인동%비염,변응성,상년성%과민반응%위험인소
Child%Rhinitis,allergic,perennial%Anaphylaxis%Risk factors
目的 初步探讨1 ～16岁具有变应性鼻炎(allergic rhinitis,AR)症状的儿童变应原致敏性的高危因素.方法 采集2011年4月至2012年11月518例1 ～16岁具有AR症状患儿的病史资料,包括基本情况、发病特点、伴发其他变应性疾病、生长发育史及遗传史等.采用UniCAP 100系统测定过敏原,分析1 ～16岁儿童AR变应原致敏性(特异性IgE≥Ⅲ级)的高危因素.以SPSS 17.0软件进行数据处理和统计学分析.结果 330/518例(63.7％)确诊为AR,首要变应原为真菌混合(52.4％);变应原特异性IgE≥Ⅲ级占相应变应原阳性例数百分率最高者为真菌混合(71.1％).单因素分析结果显示,病史月数(x2=-3.591)、是否伴发过敏性结膜炎(x2=12.325)、家中有无饲养猫或狗(x2=5.615)在AR与非变应性鼻炎两组间差异有统计学意义(P值均＜0.05).在AR患儿中,按变应原阳性级别是否≥Ⅲ级分组进行临床特征的单因素分析显示,伴发哮喘(x2=4.097)、母乳喂养(x2=4.186)、住楼房或平房(x2=4.360)、卧室朝向阳面或阴面(x2=4.656)在两组间差异有统计学意义(P值均＜0.05).在AR患儿中,按年龄分组进行单因素分析结果显示,病史月数(x2=64.999)、伴发湿疹(x2=24.056)、伴发虫咬性皮炎(x2=9.148)、家中有猫或狗(x2=8.529)、母亲患AR(x2=9.565)在不同年龄组中的差异有统计学意义(P值均＜0.05).结论 病史较长、伴发过敏性结膜炎及家中有猫或狗是AR的危险因素.在AR患儿中,非母乳喂养及卧室朝阴面是吸入组变应原特异性IgE≥Ⅲ级的危险因素.
目的 初步探討1 ～16歲具有變應性鼻炎(allergic rhinitis,AR)癥狀的兒童變應原緻敏性的高危因素.方法 採集2011年4月至2012年11月518例1 ～16歲具有AR癥狀患兒的病史資料,包括基本情況、髮病特點、伴髮其他變應性疾病、生長髮育史及遺傳史等.採用UniCAP 100繫統測定過敏原,分析1 ～16歲兒童AR變應原緻敏性(特異性IgE≥Ⅲ級)的高危因素.以SPSS 17.0軟件進行數據處理和統計學分析.結果 330/518例(63.7％)確診為AR,首要變應原為真菌混閤(52.4％);變應原特異性IgE≥Ⅲ級佔相應變應原暘性例數百分率最高者為真菌混閤(71.1％).單因素分析結果顯示,病史月數(x2=-3.591)、是否伴髮過敏性結膜炎(x2=12.325)、傢中有無飼養貓或狗(x2=5.615)在AR與非變應性鼻炎兩組間差異有統計學意義(P值均＜0.05).在AR患兒中,按變應原暘性級彆是否≥Ⅲ級分組進行臨床特徵的單因素分析顯示,伴髮哮喘(x2=4.097)、母乳餵養(x2=4.186)、住樓房或平房(x2=4.360)、臥室朝嚮暘麵或陰麵(x2=4.656)在兩組間差異有統計學意義(P值均＜0.05).在AR患兒中,按年齡分組進行單因素分析結果顯示,病史月數(x2=64.999)、伴髮濕疹(x2=24.056)、伴髮蟲咬性皮炎(x2=9.148)、傢中有貓或狗(x2=8.529)、母親患AR(x2=9.565)在不同年齡組中的差異有統計學意義(P值均＜0.05).結論 病史較長、伴髮過敏性結膜炎及傢中有貓或狗是AR的危險因素.在AR患兒中,非母乳餵養及臥室朝陰麵是吸入組變應原特異性IgE≥Ⅲ級的危險因素.
목적 초보탐토1 ～16세구유변응성비염(allergic rhinitis,AR)증상적인동변응원치민성적고위인소.방법 채집2011년4월지2012년11월518례1 ～16세구유AR증상환인적병사자료,포괄기본정황、발병특점、반발기타변응성질병、생장발육사급유전사등.채용UniCAP 100계통측정과민원,분석1 ～16세인동AR변응원치민성(특이성IgE≥Ⅲ급)적고위인소.이SPSS 17.0연건진행수거처리화통계학분석.결과 330/518례(63.7％)학진위AR,수요변응원위진균혼합(52.4％);변응원특이성IgE≥Ⅲ급점상응변응원양성례수백분솔최고자위진균혼합(71.1％).단인소분석결과현시,병사월수(x2=-3.591)、시부반발과민성결막염(x2=12.325)、가중유무사양묘혹구(x2=5.615)재AR여비변응성비염량조간차이유통계학의의(P치균＜0.05).재AR환인중,안변응원양성급별시부≥Ⅲ급분조진행림상특정적단인소분석현시,반발효천(x2=4.097)、모유위양(x2=4.186)、주루방혹평방(x2=4.360)、와실조향양면혹음면(x2=4.656)재량조간차이유통계학의의(P치균＜0.05).재AR환인중,안년령분조진행단인소분석결과현시,병사월수(x2=64.999)、반발습진(x2=24.056)、반발충교성피염(x2=9.148)、가중유묘혹구(x2=8.529)、모친환AR(x2=9.565)재불동년령조중적차이유통계학의의(P치균＜0.05).결론 병사교장、반발과민성결막염급가중유묘혹구시AR적위험인소.재AR환인중,비모유위양급와실조음면시흡입조변응원특이성IgE≥Ⅲ급적위험인소.
Objective To study the high risk factors of allergen sensitization among 1-16 years old children with allergic rhinitis (AR) symptoms.Methods Medical history was collected from 518 children with AR symptoms aged 1 to 16 years old between April 2011 and November 2012,including five aspects:basic information,disease characteristics,associated with other allergic diseases,growth and development history and genetic history and so on.The allergens were determined by UniCAP 100 system.The high risk factors of allergen sensitization(sIgE ≥ grade Ⅲ) among 1-16 years old children with AR symptoms were analyzed.The data processing and statistical analysis were conducted by SPSS 17.0 software.Results Three hundred and thirty of 518 patients (63.7％) could be diagnosed as AR.The primary allergen was mixed fungal(52.4％).The highest percentage of allergen sIgE ≥ grade Ⅲ accounted for the corresponding allergen positive cases was 71.1％ (mixed fungal).Single factor analysis of clinical characteristics in the groups of AR and non AR showed that the history of months (x2 =-3.591),concomitant allergic conjunctivitis (x2 =12.325) and cats or dogs at home (x2 =5.615) were statistically significant between the two groups(all P ＜ 0.05).In children with AR,single factor analysis of clinical characteristics in the groups of whether positive allergen level ≥ grade Ⅲ showed that the concomitant asthma (x2 =4.097),breastfeeding(x2 =4.186),the housing situation (x2 =4.360) and the bedroom toward (x2 =4.656) were statistically significant between the two groups (all P ＜ 0.05).In children with AR,single factor analysis of clinical characteristics in different age groups showed that the history of months(x2 =64.999),concomitant eczema (x2 =24.056),concomitant insect bite dermatitis (x2 =9.148),cats or dogs at home (x2 =8.529) and mother suffered from AR (x2 =9.565) were statistically significant in different age groups (all P ＜ 0.05).Conclusion The study revealed that the longer of history,concomitant allergic conjunctivitis and cats or dogs at home are risk factors for AR;In children with AR,not breastfeeding and the bedroom toward back are risk factors for inhalation allergen sIgE ≥ grade Ⅲ.
