中华耳鼻咽喉头颈外科杂志
中華耳鼻嚥喉頭頸外科雜誌
중화이비인후두경외과잡지
CHINESE JOURNAL OF OTORHINOLARYNGOLOGY HEAD AND NECK SURGERY
2014年
4期
323-325
,共3页
尤少华%张静%籍灵超%白银%王洪田
尤少華%張靜%籍靈超%白銀%王洪田
우소화%장정%적령초%백은%왕홍전
一氧化氮%呼吸试验%呼气%鼻炎,变应性,常年性%鼻炎,变应性,季节性%哮喘
一氧化氮%呼吸試驗%呼氣%鼻炎,變應性,常年性%鼻炎,變應性,季節性%哮喘
일양화담%호흡시험%호기%비염,변응성,상년성%비염,변응성,계절성%효천
Nitric oxide%Breath tests%Exhalation%Rhinitis,allergic,perennial%Rhinitis,allergic,seasonal%Asthma
目的 检测健康人和变应性鼻炎(allergic rhinitis,AR)患者口、鼻呼出气一氧化氮浓度(分别用FENO和NNO表示),并探讨其临床意义.方法 健康志愿者96名,不伴哮喘的中-重度持续性AR患者51例,用瑞典NIOX MINO仪器无创检测FENO和NNO浓度.以SPSS 13.0统计软件进行数据处理.结果 健康人的NNO浓度为245.0[189.8;331.3] ppb(中位数[25分位数;75分位数],下同),FENO浓度为14.0[10.0;18.0] ppb.AR患者的NNO浓度为304.0[179.5;397.5] ppb,FENO浓度为21.0[16.0;40.5]ppb.与健康人相比,AR患者的NNO浓度升高,但差异无统计学意义(Z=1.349,P=0.177);FENO浓度亦升高,且差异有统计学意义(Z =5.555,p=0.000).结论 中-重度持续性AR患者在无哮喘症状时FENO浓度已经显著升高,提示应该积极治疗AR预防发展成哮喘.
目的 檢測健康人和變應性鼻炎(allergic rhinitis,AR)患者口、鼻呼齣氣一氧化氮濃度(分彆用FENO和NNO錶示),併探討其臨床意義.方法 健康誌願者96名,不伴哮喘的中-重度持續性AR患者51例,用瑞典NIOX MINO儀器無創檢測FENO和NNO濃度.以SPSS 13.0統計軟件進行數據處理.結果 健康人的NNO濃度為245.0[189.8;331.3] ppb(中位數[25分位數;75分位數],下同),FENO濃度為14.0[10.0;18.0] ppb.AR患者的NNO濃度為304.0[179.5;397.5] ppb,FENO濃度為21.0[16.0;40.5]ppb.與健康人相比,AR患者的NNO濃度升高,但差異無統計學意義(Z=1.349,P=0.177);FENO濃度亦升高,且差異有統計學意義(Z =5.555,p=0.000).結論 中-重度持續性AR患者在無哮喘癥狀時FENO濃度已經顯著升高,提示應該積極治療AR預防髮展成哮喘.
목적 검측건강인화변응성비염(allergic rhinitis,AR)환자구、비호출기일양화담농도(분별용FENO화NNO표시),병탐토기림상의의.방법 건강지원자96명,불반효천적중-중도지속성AR환자51례,용서전NIOX MINO의기무창검측FENO화NNO농도.이SPSS 13.0통계연건진행수거처리.결과 건강인적NNO농도위245.0[189.8;331.3] ppb(중위수[25분위수;75분위수],하동),FENO농도위14.0[10.0;18.0] ppb.AR환자적NNO농도위304.0[179.5;397.5] ppb,FENO농도위21.0[16.0;40.5]ppb.여건강인상비,AR환자적NNO농도승고,단차이무통계학의의(Z=1.349,P=0.177);FENO농도역승고,차차이유통계학의의(Z =5.555,p=0.000).결론 중-중도지속성AR환자재무효천증상시FENO농도이경현저승고,제시응해적겁치료AR예방발전성효천.
Objective To measure the nasal nitric oxide (NNO) and fractional exhaled nitric oxide (FENO) in healthy people and patients with allergic rhinitis (AR),and to discuss the clinical significance of the results.Methods Ninety-six healthy volunteers and 51 patients with moderate-severe persistent AR,but without asthma,were enrolled.NNO and FENO concentrations were measured noninvasively by using of NIOX MINO (Aerocrine AB,Solna,Sweden).SPSS 13.0 software was used to analyze the data.Results The concentration of NNO in healthy people was 245.0 [189.8 ;331.3] ppb (median [25th percentile ; 75th percentile],the followings were same as).The concentration of FENO was 14.0 [10.0; 18.0] ppb.The concentration of NNO in patients with AR was 304.0 [179.5 ; 397.5] ppb.The concentration of FENO was 21.0[16.0; 40.5] ppb.The concentration of NNO in the AR patients was higher than that in the healthy persons,but the difference did not reach statistical significance (Z =1.349,P =0.177).On the other hand,FENO concentrations were significantly increased in patients compared with concentrations in healthy persons (Z =5.555,P =0.000).Conclusions FENO concentrations of patients with moderate-severe persistent AR are increased significantly even though the patients do not have typical symptoms of asthma.This finding suggests that AR patients should be treated actively in order to prevent asthma from developing in them.
