CAJ | 학술논문

目的分析轻度认知障碍患者嗅球体积、嗅沟深度与嗅觉功能的相关性.方法选取轻度认知障碍患者(测试组)及无认知障碍的健康受试者(对照组)各50例,应用T&T嗅觉测试法检查所有受试者的嗅觉功能,并行嗅球体积、嗅沟深度的MRI检查.以简易精神状态检查表(MMSE)、蒙特利尔认知评估表(MoCA)、日常生活活动量表(ADL)检测评估认知障碍.以SPSS 13.0软件进行统计学分析.结果测试组T&T嗅觉识别阈分数明显高于对照组,差异有统计学意义(t=3.142,P＜0.05).测试组男女嗅觉识别阈差异无统计学意义(t=0.973,P＞0.05),对照组男女嗅觉识别阈差异无统计学意义(t=1.092,P＞0.05).测试组左右两侧嗅球体积、平均嗅球体积[分别为(36.35±4.09)、(36.57±4.13)、(36.47±4.12) mm3]均明显小于对照组[分别为(46.65±6.23)、(46.83±6.27)、(46.71±6.25)mm3],差异有统计学意义(t值分别为3.113、3.145、3.132,P值均＜0.01).测试组与对照组左右两侧嗅沟深度及平均嗅沟深度差异无统计学意义(t值分别为0.876、0.952、0.904,P值均＞0.05).测试组及对照组嗅觉识别阈与嗅球体积呈负相关趋势(r值分别为-0.643,-0.541,P值均＜0.05),与嗅沟深度无关(r值分别为-0.167,-0.183,P值均＞0.05).测试组嗅觉识别阈与MMSE、MoCA、ADL呈负相关趋势(r值分别为-0.427,-0.418,-0.399,P值均＜0.05),测试组平均嗅球体积与MMSE、MoCA、ADL呈正相关趋势(r值分别为0.364,0.383,0.379,P值均＜0.05).结论轻度认知障碍患者嗅球体积减小,嗅沟深度不变;嗅觉功能与嗅球体积具有相关性,与嗅沟深度无关;认知障碍的严重程度与嗅觉减退的程度具有一致性;嗅觉功能减退可作为轻度认知功能障碍患者早期客观诊断的参考指标.
목적 분석경도인지장애환자후구체적、후구심도여후각공능적상관성.방법 선취경도인지장애환자(측시조)급무인지장애적건강수시자(대조조)각50례,응용T&T후각측시법검사소유수시자적후각공능,병행후구체적、후구심도적MRI검사.이간역정신상태검사표(MMSE)、몽특리이인지평고표(MoCA)、일상생활활동량표(ADL)검측평고인지장애.이SPSS 13.0연건진행통계학분석.결과 측시조T&T후각식별역분수명현고우대조조,차이유통계학의의(t=3.142,P＜0.05).측시조남녀후각식별역차이무통계학의의(t=0.973,P＞0.05),대조조남녀후각식별역차이무통계학의의(t=1.092,P＞0.05).측시조좌우량측후구체적、평균후구체적[분별위(36.35±4.09)、(36.57±4.13)、(36.47±4.12) mm3]균명현소우대조조[분별위(46.65±6.23)、(46.83±6.27)、(46.71±6.25)mm3],차이유통계학의의(t치분별위3.113、3.145、3.132,P치균＜0.01).측시조여대조조좌우량측후구심도급평균후구심도차이무통계학의의(t치분별위0.876、0.952、0.904,P치균＞0.05).측시조급대조조후각식별역여후구체적정부상관추세(r치분별위-0.643,-0.541,P치균＜0.05),여후구심도무관(r치분별위-0.167,-0.183,P치균＞0.05).측시조후각식별역여MMSE、MoCA、ADL정부상관추세(r치분별위-0.427,-0.418,-0.399,P치균＜0.05),측시조평균후구체적여MMSE、MoCA、ADL정정상관추세(r치분별위0.364,0.383,0.379,P치균＜0.05).결론 경도인지장애환자후구체적감소,후구심도불변;후각공능여후구체적구유상관성,여후구심도무관;인지장애적엄중정도여후각감퇴적정도구유일치성;후각공능감퇴가작위경도인지공능장애환자조기객관진단적삼고지표.
Objective To analyze the correlation between olfactory bulb (OB) volume,depth of olfactory sulcus (OS) and olfactory function in patients with mild cognitive impairment (MCI).Methods Fifty patients with MCI were compared with fifty controls in terms of olfactory function T&T testing,OB volume and depth of OS assessed with magnetic resonance imaging (MRI).SPSS 13.0 software was used to analyze the data.Results T&T olfactory testing revealed that MCI patients had higher scores than controls (t =3.142,P ＜0.05).Both men and women with MCI were affected by the same extent of olfactory loss(t =0.973,P ＞0.05).Both men and women as controls were affected by the same extent of olfactory loss(t =1.092,P ＞ 0.05).OB volume of left side in MCI patients was (36.35 ± 4.09)mm3,right side was (36.57 ±4.13)mm3,average OB volume was (36.47 ±4.12)mm3 ; OB volume of left side in controls was (46.65 ± 6.23) mm3,right side was (46.83 ± 6.27) mm3,average OB volume was (46.71 ± 6.25)mm3 ; OB volumes were lower in MCI patients as compared with controls(t value was 3.113,3.145 and 3.132,allP ＜0.01).OS depth study revealed no statistical different between MCI patients and controls(t value was 0.876,0.952 and 0.904,all P ＞ 0.05).Olfactory discriminate threshold was negatively correlated with OB volume in MCI patients and controls(r value was-0.643,-0.541,both P ＜0.05) ; was no correlated with depth of OS (r value was-0.167 and-0.183,both P ＞ 0.05).Olfactory discriminate threshold was negatively correlated with cognitive impairment degree in MCI patients(r value was-0.427,-0.418 and-0.399,all P ＜ 0.05),average OB volume was positively correlated with cognitive impairment degree in MCI patients(r value was 0.364,0.383 and 0.379,all P ＜0.05).Conclusions The OB volumes are lower in MCI patients as compared with controls,the depth of OS show no significant changes in MCI patients.The OB volume is correlated with olfactory function,the depth of OS is not correlated with olfactory function.Cognitive impairment degree in MCI patients is accordance with olfactory function lower degree.The olfactory loss may be a earlier period and objective diagnosis indicator for MCI patients.