CAJ | 학술논문

目的研究纳米碳在青少年甲状腺乳头状癌患者的术中淋巴结检出数及甲状旁腺损伤情况.方法本研究回顾性收集51例青少年患者的临床病理资料,51例患者中,男性16例,女性35例.男女比例为1∶2.19,年龄14～29岁(中位年龄26岁).本组研究分为2组,18例患者为纳米碳组,33例为常规手术组.通过Wilcoxon秩和检验及卡方检验分析比较两组患者检出淋巴结数目的差异和纳米碳对甲状旁腺的保护作用.结果两组在年龄、性别、临床分期、TNM分期及手术方式差异无统计学意义(P＞0.05).纳米碳组总淋巴结检出数多于常规手术组(Z=-2.258,P＜0.05).然而,两组总淋巴结转移检出数差异无统计学意义(Z=-0.396,P＞0.05).纳米碳注射组Ⅵ区的检出淋巴结数多于常规手术组(Z=-2.461,P＜0.05),Ⅵ区转移淋巴结检出数差异无统计学意义(Z=-1.396,P＞0.05).中央区清扫组织中检出甲状旁腺比例纳米碳组低于常规手术组,分别为5.5％,18.2％(x2=1.568,P＞0.05),差异无统计学意义.结论纳米碳可考虑作为有效的淋巴示踪剂用于青少年甲状腺乳头状癌手术.纳米碳是否能保护甲状旁腺,减少甲状旁腺功能低下的发生率,仍需要进一步的观察.
목적 연구납미탄재청소년갑상선유두상암환자적술중림파결검출수급갑상방선손상정황.방법 본연구회고성수집51례청소년환자적림상병리자료,51례환자중,남성16례,녀성35례.남녀비례위1∶2.19,년령14～29세(중위년령26세).본조연구분위2조,18례환자위납미탄조,33례위상규수술조.통과Wilcoxon질화검험급잡방검험분석비교량조환자검출림파결수목적차이화납미탄대갑상방선적보호작용.결과 량조재년령、성별、림상분기、TNM분기급수술방식차이무통계학의의(P＞0.05).납미탄조총림파결검출수다우상규수술조(Z=-2.258,P＜0.05).연이,량조총림파결전이검출수차이무통계학의의(Z=-0.396,P＞0.05).납미탄주사조Ⅵ구적검출림파결수다우상규수술조(Z=-2.461,P＜0.05),Ⅵ구전이림파결검출수차이무통계학의의(Z=-1.396,P＞0.05).중앙구청소조직중검출갑상방선비례납미탄조저우상규수술조,분별위5.5％,18.2％(x2=1.568,P＞0.05),차이무통계학의의.결론 납미탄가고필작위유효적림파시종제용우청소년갑상선유두상암수술.납미탄시부능보호갑상방선,감소갑상방선공능저하적발생솔,잉수요진일보적관찰.
Objective To investigate the number of dissected lymph nodes and the incidence of injury to parathyroid glands during surgery for papillary thyroid carcinoma (DTC) in young patients.Methods This study collected clinicopathological data of 51 young patients with PTC.Of the 51 patients,18 patients were classified into carbon nanoparticles group (CNP group) and 33 patients into traditional surgical group (TS group).The number of dissected lymph nodes and the incidence of injury to parathyroid glands were analyzed using Wilcoxon rank sum test and chi-square test.Results There were 16 males and 35 females,with a male/female ratio of 1:2.19.The age ranged from 14 to 29 (25 ±3.9) years.There was no statistically significant difference in age,gender,T-classification,TNM stage and surgical procedures between two groups (P ＞ 0.05).The total number of dissected lymph nodes in CNP group was higher than that in TS group(Z =-2.258,P ＜ 0.05).However,significant difference in the total number of metastatic lymph nodes between the two groups was not found (Z =-0.396,P ＞ 0.05).In level Ⅵ,the detected lymph node number of group CNP was higher than that of TS group (Z =-2.461,P ＜ 0.05) but there was no significant difference in the detected number of metastatic lymph nodes (Z =-1.396,P ＞ 0.05).The rates of injury to parathyroid gland were 5.5％ in CNP group and 18.2％ in TS group,respectively(x2 =1.568,P ＞ 0.05).Conclusion Carbon nanoparticles could be an effective lymph nodes tracer applying to PTC operation in young patients.