CAJ | 학술논문

目的分析上海市闵行区2007至2010年预防接种不良反应及临床表现.方法通过预防接种不良反应监测系统收集数据,将不良反应分为一般反应、异常反应,进行描述性分析.结果上海市闵行区在2007至2010年间开展了包括病毒、细菌、非疫苗3大类共24种制品485.55万剂次的接种,共报告20种制品预防接种后不良反应5088例,其中一般反应5013例,报告率为103.24/10万,主要有发热(3314例,68.25/10万)、局部反应(1686例,34.72/10万);异常反应75例,报告率为1.54/10万,主要有急性过敏反应(26例,0.54/10万)、过敏性皮疹(24例,0.49/10万)和接种部位脓肿(14例,0.29/10万).2007至2010年不良反应报告的敏感性逐年上升,报告率由2007年的40.48/10万提高到2010年的134.17/10万.结论不良反应监测可以发现罕见的异常反应,应加强监测的敏感性,同时儿科医师也应了解处理不良反应的规范,从而及时处置不良反应,减少对预防接种工作的负面影响,增强公众对预防接种的信心.
목적 분석상해시민행구2007지2010년예방접충불량반응급림상표현.방법 통과예방접충불량반응감측계통수집수거,장불량반응분위일반반응、이상반응,진행묘술성분석.결과 상해시민행구재2007지2010년간개전료포괄병독、세균、비역묘3대류공24충제품485.55만제차적접충,공보고20충제품예방접충후불량반응5088례,기중일반반응5013례,보고솔위103.24/10만,주요유발열(3314례,68.25/10만)、국부반응(1686례,34.72/10만);이상반응75례,보고솔위1.54/10만,주요유급성과민반응(26례,0.54/10만)、과민성피진(24례,0.49/10만)화접충부위농종(14례,0.29/10만).2007지2010년불량반응보고적민감성축년상승,보고솔유2007년적40.48/10만제고도2010년적134.17/10만.결론 불량반응감측가이발현한견적이상반응,응가강감측적민감성,동시인과의사야응료해처리불량반응적규범,종이급시처치불량반응,감소대예방접충공작적부면영향,증강공음대예방접충적신심.
Objective To analyze the adverse events following immunization (AEFI) in Minhang District of Shanghai from 2007 to 2010 and evaluate the safety of vaccines.Method The data of AEFI cases were collected and reported by the Vaccine Adverse Events Surveillance System (VAESS).The data were classified as non-serious or serious reaction according to the symptoms and medical records.Result From 2007 to 2010,5088 AEFI cases were reported to the surveillance system after 4.85 million doses of 24 kinds of vaccines (viral vaccines,bacterial vaccine and non-vaccine product) use.A total of 5013 non-serious AEFI were reported with a rate of 103.24/100 000 doses.Among the non-serious AEFIs,the majority were fever (3314 cases,68.25/100 000 doses),followed by local reactions (1686 cases,34.72/100 000 doses).A total of 75 serious AEFIs were reported,with a rate of 1.54/100 000 doses.The anaphylaxis (26 cases,0.54/100 000 doses) accounted for the most among the serious AEFIs,followed by allergic rash (24 cases,0.49/100 000 doses) and abscess at injection site (14 cases,0.29/100 000doses).The susceptibility of data on AEFI rose year by year from 2007 to 2010,and the reported rate rose from 40.48/100 000 in 2007 to 134.17/100 000 in 2010.Conclusion To maintain the sensitivity of AEFI surveillance is key to detect rare serious adverse events.The sensitivity should be enhanced,at the same time,pediatricians should treat the AEFI with standard methods,so as to minimize the negative impacts of vaccination and to maintain the confidence among the public.