中华儿科杂志
中華兒科雜誌
중화인과잡지
Chinese Journal of Pediatrics
2014年
2期
107-111
,共5页
吴尤佳%邵志莉%高薇薇%李海英%徐美玉
吳尤佳%邵誌莉%高薇薇%李海英%徐美玉
오우가%소지리%고미미%리해영%서미옥
唾液酸%智能%足月%婴儿%围产期
唾液痠%智能%足月%嬰兒%圍產期
타액산%지능%족월%영인%위산기
Sialic acid%Intelligence%Full term%Infant%Perinatal period
目的 分析围产期唾液酸(SA)营养状况与健康足月儿早期智能发育的关系,探讨SA水平对早期智能发育的影响.方法 采取前瞻性队列研究,随机调查127对南通大学附属医院健康产妇及其婴儿,对产妇问卷调查,采用酶联免疫吸附法测定母婴体液SA水平,婴儿出生后3～4个月评估精神发育指数(MDI)和运动发育指数(PDI).结果 共获得120对完整的资料:母血、脐血及初乳中的SA水平分别为(2.25±0.02)、(1.21±0.01)、(5.01±0.06) mmol/L;3～4月龄的婴儿MDI和PDI分别为(99.40±1.87)、(98.53±1.96).多元逐步回归分析表明:MDI与脐血及初乳中的SA水平相关(β=0.636、0.175,P＜0.05),PDI与脐血及初乳中的SA水平相关(β=0.502、0.262,P＜0.05).脐血高SA组的MDI、PDI均显著高于低SA组(111.85±2.79)vs.(108.88±2.0),(101.08±4.44)vs.(98.88±2.0),P均＜0.01;初乳高SA组的MDI、PDI均显著高于低SA组(111.71 ±3.07)vs.(108.81±1.56),P＜0.01;(101.29±4.23)vs.(98.56±1.79),P＜0.05.初乳与脐血SA水平呈正相关(r =0.507,P=0.004);初乳及脐血SA水平在母血高SA组均显著高于低SA组(5.12±0.35)vs.(4.87±0.22),(1.21±0.02)vs.(1.17±0.01),P均＜0.05.结论 脐血及初乳唾液酸高水平可能有益于足月儿早期智能发育,围产期充足的唾液酸摄入和良好的胎盘功能可能是早期智能发育的重要因素.
目的 分析圍產期唾液痠(SA)營養狀況與健康足月兒早期智能髮育的關繫,探討SA水平對早期智能髮育的影響.方法 採取前瞻性隊列研究,隨機調查127對南通大學附屬醫院健康產婦及其嬰兒,對產婦問捲調查,採用酶聯免疫吸附法測定母嬰體液SA水平,嬰兒齣生後3～4箇月評估精神髮育指數(MDI)和運動髮育指數(PDI).結果 共穫得120對完整的資料:母血、臍血及初乳中的SA水平分彆為(2.25±0.02)、(1.21±0.01)、(5.01±0.06) mmol/L;3～4月齡的嬰兒MDI和PDI分彆為(99.40±1.87)、(98.53±1.96).多元逐步迴歸分析錶明:MDI與臍血及初乳中的SA水平相關(β=0.636、0.175,P＜0.05),PDI與臍血及初乳中的SA水平相關(β=0.502、0.262,P＜0.05).臍血高SA組的MDI、PDI均顯著高于低SA組(111.85±2.79)vs.(108.88±2.0),(101.08±4.44)vs.(98.88±2.0),P均＜0.01;初乳高SA組的MDI、PDI均顯著高于低SA組(111.71 ±3.07)vs.(108.81±1.56),P＜0.01;(101.29±4.23)vs.(98.56±1.79),P＜0.05.初乳與臍血SA水平呈正相關(r =0.507,P=0.004);初乳及臍血SA水平在母血高SA組均顯著高于低SA組(5.12±0.35)vs.(4.87±0.22),(1.21±0.02)vs.(1.17±0.01),P均＜0.05.結論 臍血及初乳唾液痠高水平可能有益于足月兒早期智能髮育,圍產期充足的唾液痠攝入和良好的胎盤功能可能是早期智能髮育的重要因素.
목적 분석위산기타액산(SA)영양상황여건강족월인조기지능발육적관계,탐토SA수평대조기지능발육적영향.방법 채취전첨성대렬연구,수궤조사127대남통대학부속의원건강산부급기영인,대산부문권조사,채용매련면역흡부법측정모영체액SA수평,영인출생후3～4개월평고정신발육지수(MDI)화운동발육지수(PDI).결과 공획득120대완정적자료:모혈、제혈급초유중적SA수평분별위(2.25±0.02)、(1.21±0.01)、(5.01±0.06) mmol/L;3～4월령적영인MDI화PDI분별위(99.40±1.87)、(98.53±1.96).다원축보회귀분석표명:MDI여제혈급초유중적SA수평상관(β=0.636、0.175,P＜0.05),PDI여제혈급초유중적SA수평상관(β=0.502、0.262,P＜0.05).제혈고SA조적MDI、PDI균현저고우저SA조(111.85±2.79)vs.(108.88±2.0),(101.08±4.44)vs.(98.88±2.0),P균＜0.01;초유고SA조적MDI、PDI균현저고우저SA조(111.71 ±3.07)vs.(108.81±1.56),P＜0.01;(101.29±4.23)vs.(98.56±1.79),P＜0.05.초유여제혈SA수평정정상관(r =0.507,P=0.004);초유급제혈SA수평재모혈고SA조균현저고우저SA조(5.12±0.35)vs.(4.87±0.22),(1.21±0.02)vs.(1.17±0.01),P균＜0.05.결론 제혈급초유타액산고수평가능유익우족월인조기지능발육,위산기충족적타액산섭입화량호적태반공능가능시조기지능발육적중요인소.
Objective To investigate the correlation between the status of sialic acid (SA) during perinatal period and early intelligence development of healthy full term infant,and to explore the effect of SA on the early intelligence development.Method A total of 127 pairs of healthy mothers-neonates in the Affiliated Hospital of Nantong University were recruited randomly in this prospective cohort study.The levels of SA from body fluids of mothers-neonates were measured by enzyme-linked immunosorbent assay,such as the full-term maternal and cord blood and the colostrum.The questionnaire surveys were carried out in mothers and mental development evaluation according to Children's Development Center of China (CDCC) were carried out in infants 3 to 4 months of age to obtain the mental development index (MDI) and psychomotor development index (PDI).Result A total of 120 pairs of maternal-neonatal subjects with complete data were included into statistical analysis.The levels of SA of maternal and cord blood and colostrum were (2.25 ±0.02),(1.21 ±0.01),and (5.01 ±0.06) mmol/L respectively.MDI and PDI of infants 3 to 4 months of age were (99.40 ± 1.87) and (98.53 ± 1.96).The analysis using multiple linear regression indicated that MDI was associated with SA levels of cord blood and colostrum (β =0.636,0.175,P ＜0.05),and PDI was also associated with them (β =0.502,0.262,P ＜0.05).The levels of SA of cord blood and colostrums were individually divided into high-level group and low-level one according to the median level.MDI and PDI in high-level group of cord blood were both significantly higher than that in lowlevel group (111.85 ± 2.79) vs.(108.88 ± 2.0),(101.08 ± 4.44) vs.(98.88 ± 2.0) P ＜ 0.01.So were MDI and PDI in high-level group of colostrum compared with those in low-level group (111.71 ±3.07) vs.(108.81 ± 1.56),P ＜ 0.01 ; (101.29 ± 4.23) vs.(98.56 ± 1.79),P ＜ 0.05.The analysis on correlation between the levels of maternal-neonatal body fluids showed that the level of SA of colostrum was positively correlated with that of cord blood (r =0.507,P =0.004).However,no correlation was found either between the level of SA of maternal and cord blood or between the level of SA of maternal blood and colostrums.Further division into high-level and low-level groups was done according to the median level of maternal blood.The levels of SA of colostrum and cord blood in high-level group were markedly higher than those in low-levelone (5.12±0.35) vs.(4.87 ±0.22) and (1.21 ±0.02) vs.(1.17±0.01),P＜0.05.Conclusion High levels of SA of cord blood and colostrums might be beneficial to the early intelligence development of full term infant.Abundant intake of SA during perinatal period and good function of placenta may play important role in early intelligence development.
