中华妇产科杂志
中華婦產科雜誌
중화부산과잡지
CHINESE JOUNAL OF OBSTETRICS AND GYNECOLOGY
2014年
6期
424-427
,共4页
路锦%张翠莲%张少娣%耿嘉瑄%张宜瑄
路錦%張翠蓮%張少娣%耿嘉瑄%張宜瑄
로금%장취련%장소제%경가선%장의선
胚胎移植%孕酮%子宫内膜%妊娠结局
胚胎移植%孕酮%子宮內膜%妊娠結跼
배태이식%잉동%자궁내막%임신결국
Embryo transfer%Progesterone%Endometrium%Pregnancy outcome
目的 探讨冻融胚胎移植中,孕酮转化子宫内膜时间对妊娠结局的影响.方法 回顾性分析2012年1月至12月在河南省人民医院生殖医学中心采用人工周期准备子宫内膜进行冻融胚胎移植的1 103个周期的妊娠结局.根据孕酮转化子宫内膜时间的不同分为4组:3-3组(543个周期,孕酮转化子宫内膜3d后移植第3天卵裂期胚胎),4-3组(330个周期,孕酮转化子宫内膜4d后移植第3天卵裂期胚胎),5-5组(150个周期,孕酮转化子宫内膜5d后移植第5天囊胚),6-5组(80个周期,孕酮转化内膜6d后移植第5天囊胚).比较各组的种植率、妊娠率、异位妊娠率、多胎妊娠率、早期流产率.结果 种植率3-3组为39.9％ (429/1 074)、4-3组为44.1％(286/648);妊娠率3-3组为56.0％(304/543)、4-3组为59.4％ (196/330);异位妊娠率3-3组为3.3％(10/304)、4-3组为2.6％(5/196);多胎妊娠率3-3组为38.5％ (117/304)、4-3组为43.4％(85/196);早期流产率3-3组为13.5％(41/304)、4-3组为13.3％ (26/196);3-3组与4-3组各指标分别比较,差异均无统计学意义(P＞0.05).种植率5-5组为64.7％(191/295)、6-5组为69.4％(100/144);妊娠率5-5组为80.7％(121/150)、6-5组为78.8％(63/80);异位妊娠率5-5组为2.5％(3/121)、6-5组为0;多胎妊娠率5-5组为55.4％(67/121)、6-5组为46.3％ (37/80);早期流产率5-5组为5.8％ (7/121)、6-5组为7.9％ (5/63);5-5组与6-5组各指标分别比较,差异也均无统计学意义(P＞0.05).结论 孕酮转化子宫内膜不同时间后移植胚胎均可获得满意的妊娠结局.
目的 探討凍融胚胎移植中,孕酮轉化子宮內膜時間對妊娠結跼的影響.方法 迴顧性分析2012年1月至12月在河南省人民醫院生殖醫學中心採用人工週期準備子宮內膜進行凍融胚胎移植的1 103箇週期的妊娠結跼.根據孕酮轉化子宮內膜時間的不同分為4組:3-3組(543箇週期,孕酮轉化子宮內膜3d後移植第3天卵裂期胚胎),4-3組(330箇週期,孕酮轉化子宮內膜4d後移植第3天卵裂期胚胎),5-5組(150箇週期,孕酮轉化子宮內膜5d後移植第5天囊胚),6-5組(80箇週期,孕酮轉化內膜6d後移植第5天囊胚).比較各組的種植率、妊娠率、異位妊娠率、多胎妊娠率、早期流產率.結果 種植率3-3組為39.9％ (429/1 074)、4-3組為44.1％(286/648);妊娠率3-3組為56.0％(304/543)、4-3組為59.4％ (196/330);異位妊娠率3-3組為3.3％(10/304)、4-3組為2.6％(5/196);多胎妊娠率3-3組為38.5％ (117/304)、4-3組為43.4％(85/196);早期流產率3-3組為13.5％(41/304)、4-3組為13.3％ (26/196);3-3組與4-3組各指標分彆比較,差異均無統計學意義(P＞0.05).種植率5-5組為64.7％(191/295)、6-5組為69.4％(100/144);妊娠率5-5組為80.7％(121/150)、6-5組為78.8％(63/80);異位妊娠率5-5組為2.5％(3/121)、6-5組為0;多胎妊娠率5-5組為55.4％(67/121)、6-5組為46.3％ (37/80);早期流產率5-5組為5.8％ (7/121)、6-5組為7.9％ (5/63);5-5組與6-5組各指標分彆比較,差異也均無統計學意義(P＞0.05).結論 孕酮轉化子宮內膜不同時間後移植胚胎均可穫得滿意的妊娠結跼.
목적 탐토동융배태이식중,잉동전화자궁내막시간대임신결국적영향.방법 회고성분석2012년1월지12월재하남성인민의원생식의학중심채용인공주기준비자궁내막진행동융배태이식적1 103개주기적임신결국.근거잉동전화자궁내막시간적불동분위4조:3-3조(543개주기,잉동전화자궁내막3d후이식제3천란렬기배태),4-3조(330개주기,잉동전화자궁내막4d후이식제3천란렬기배태),5-5조(150개주기,잉동전화자궁내막5d후이식제5천낭배),6-5조(80개주기,잉동전화내막6d후이식제5천낭배).비교각조적충식솔、임신솔、이위임신솔、다태임신솔、조기유산솔.결과 충식솔3-3조위39.9％ (429/1 074)、4-3조위44.1％(286/648);임신솔3-3조위56.0％(304/543)、4-3조위59.4％ (196/330);이위임신솔3-3조위3.3％(10/304)、4-3조위2.6％(5/196);다태임신솔3-3조위38.5％ (117/304)、4-3조위43.4％(85/196);조기유산솔3-3조위13.5％(41/304)、4-3조위13.3％ (26/196);3-3조여4-3조각지표분별비교,차이균무통계학의의(P＞0.05).충식솔5-5조위64.7％(191/295)、6-5조위69.4％(100/144);임신솔5-5조위80.7％(121/150)、6-5조위78.8％(63/80);이위임신솔5-5조위2.5％(3/121)、6-5조위0;다태임신솔5-5조위55.4％(67/121)、6-5조위46.3％ (37/80);조기유산솔5-5조위5.8％ (7/121)、6-5조위7.9％ (5/63);5-5조여6-5조각지표분별비교,차이야균무통계학의의(P＞0.05).결론 잉동전화자궁내막불동시간후이식배태균가획득만의적임신결국.
Objective To investigate the pregnancy outcome of frozen-thawed embryos transfer in different endometrial progesterone preparation time.Methods From January to December 2012,pregnant outcome of 1 103 frozen-thawed embryo transfer cycles using artificial periodic endometrial preparation were studied retrospectively in Reproductive Medical Center of Henan Provincial People's Hospital.It was divided into 4 groups:group 3-3 (n =543,3 days after endometrial progesterone preparation and transfer D3 embryo),group 4-3(n =330,4 days after endometrial progesterone preparation and transfer D3 embryo),group 5-5 (n =150,5 days after endometrial progesterone preparation and transfer D5 blastula),group 6-5 (n =80,6 days after endometrial progesterone preparation and transfer D5 blastula).The rate of implantation,pregnancy,ectopic pregnancy,multiple pregnancy,and first trimester abortion were compared among those groups.Results (1) With the different endometrial progesterone preparation methods and transfer D3 embryos,implantation rate [group 3-3:39.9％ (429/1 074) ; group 4-3:44.1％ (286/648)],pregnancy rate [group 3-3:56.0％ (304/543) ; group 4-3:59.4％ (196/330)],ectopic pregnancy rate [group 3-3:3.3％ (10/304) ; group 4-3:2.6％ (5/196)],multiple pregnancy rate [group 3-3:38.5％ (117/304) ; group 4-3:43.4％ (85/196)]and early abortion rate[group 3-3:13.5％ (41/304); group 4-3:13.3％ (26/196)] had no significant differences between group 3-3 and group 4-3 (all P ＞ 0.05).(2) With the different endometrial progesterone preparation methods and transfer D5 blastocysts,implantation rate [group 5-5:64.7％ (191/295) ; group 6-5:69.4％ (100/144)],pregnancy rate [group 5-5:80.7％ (121/150) ; group 6-5:78.8％ (63/80)],ectopic pregnancy rate [group 5-5:2.5％ (3/121) ; group 6-5:0],multiple pregnancy rate[group 5-5:55.4％ (67/121) ; group 6-5:46.3％ (37/80)] and early abortion rate[group 5-5:5.8％ (7/121); group 6-5:7.9％ (5/63)].However,there were no significantly differences between group 5-5 and group 6-5 (all P ＞ 0.05).Conclusions The two different progesterone transformed endometrial methods can obtain satisfactory clinical outcome with D3 embryo or D5 blastocysts transfor.It is convenient to clinical and laboratory work arrangements.
