CAJ | 학술논문

目的探讨性激素替代疗法(HRT)对类风湿关节炎(RA)的疗效.方法检索国内外公开发表的关于HRT治疗RA的随机对照试验文献,筛选合格文献进行研究,运用异质性检验、Meta分析等方法统计相关数据.结果共有11项研究符合纳入标准.HRT与安慰剂相比能够降低RA患者的红细胞沉降率(ESR)水平,标准均数差(SMD)为-0.22(-0.40,-0.04),P=0.016;升高患者的骨密度水平,加权均数差(WMD)为2.83(0.41,5.26),P=0.022;降低患者的临床评价指标,SMD为-0.19(-0.38,0.00),P=0.048；降低患者的C反应蛋白(CRP)水平,SMD为-0.08(-0.37,0.21),但差异不具有统计学意义(P=0.591).结论 Meta分析结果显示,HRT能够降低RA患者的ESR水平及临床评价指标,并提高患者的骨密度水平,HRT能够减轻RA患者的病情活动并且抑制骨质疏松,可作为RA治疗的新方法或辅助治疗手段.
목적 탐토성격소체대요법(HRT)대류풍습관절염(RA)적료효.방법 검색국내외공개발표적관우HRT치료RA적수궤대조시험문헌,사선합격문헌진행연구,운용이질성검험、Meta분석등방법통계상관수거.결과 공유11항연구부합납입표준.HRT여안위제상비능구강저RA환자적홍세포침강솔(ESR)수평,표준균수차(SMD)위-0.22(-0.40,-0.04),P=0.016;승고환자적골밀도수평,가권균수차(WMD)위2.83(0.41,5.26),P=0.022;강저환자적림상평개지표,SMD위-0.19(-0.38,0.00),P=0.048；강저환자적C반응단백(CRP)수평,SMD위-0.08(-0.37,0.21),단차이불구유통계학의의(P=0.591).결론 Meta분석결과현시,HRT능구강저RA환자적ESR수평급림상평개지표,병제고환자적골밀도수평,HRT능구감경RA환자적병정활동병차억제골질소송,가작위RA치료적신방법혹보조치료수단.
Objective To explore the efficacy of hormone replacement therapy (HRT) for rheumatoid arthritis (RA).Methods The literature about HRT in the treatment of rheumatoid arthritis were searched.Eleven papers were subjected to a Meta-analysis and a heterogeneity test was conducted to evaluate the efficacy of HRT.Results HRT reduced the level of erythrocyte sedimentation rate (ESR) in RA patients (P=0.016),the SMD was-0.22(-0.40,-0.04); improved bone mineral density (BMD) in RA patients (P=0.022),the WMD was 2.83(0.41,5.26); decreased clinical parameters for disease activity evaluations of RA patients (P=0.048),the SMD was-0.19 (-0.38,0.00); decreased the level of C-reactive protein (CRP) in RA patients,the SMD was-0.08 (-0.37,0.21),but the difference was not statistically significant (P=0.591).Conclusion The findings from this Meta-analysis indicate that HRT can reduce the ESR level,improve clinical indexes and improve BMD level of RA patients.HRT may suppress disease activity and osteoporosis of RA patients,so it may be used as an auxiliary therapy in the treatment of RA.