CAJ | 학술논문

目的分析2009-2012年过敏性紫癜(HSP)及紫癜性肾炎(HSPN)住院患儿的发病情况,了解其在江西地区的流行特征.方法利用2009-2012年在江西省儿童医院住院的HSP和HSPN患儿病案首页信息资料,分析不同地区、不同时间、不同性别和年龄的发病情况及其变化,同时与其他地区的发病情况进行比较,采用x2检验进行统计分析.结果 2009-2012年新发HSP住院患儿2516例,各年度依次为412、568、750、786例；其中诊断HSPN患儿分别为110、148、198、196例,年平均肾脏受累率为25.91％(652/2516).各年度肾损害发生率比较差异无统计学意义(x2=0.62,P＞0.05).HSP男女性别比为1.59∶1,4～9岁组65.50％(1648/2516),为发病高峰年龄段.不同性别组HSP肾脏受累率差异无统计学意义(x2=0.14,P＞0.05)；不同年龄段HSP肾脏受累率不同,分别为＜6岁组18.76％(163/869)、6～11岁组26.85％(359/1337)、≥11岁组41.94％(130/310),各组比较差异有统计学意义(x2=65.24,P＜0.01).不同月份HSP发病率有差别,每年10月至12月为发病高峰,占新发病例40.74％(1025/2516).不同月份HSP肾脏受累率不同,1月至3月HSPN发生率30.23％(208/688)高于其他月份,各组差异有统计学意义(x2=9.87,P＜O.05).近4年江西省各地区HSP住院患者数:南昌地区824例(32.75％)、非南昌地区1692例(67.25％),南昌地区HSP肾脏受累率17.35％(143/824)低于各地平均值25.91％(652/2516),2组比较差异有统计学意义(x2=25.08,P＜0.01).结论本地区HSP发病数逐年增加,发病高峰为每年10月至12月,4～9岁为发病高峰年龄段.HSPN在1月至3月发生率高于其他月份,随着年龄增长HSP累及肾脏的比率逐渐增加 .
목적 분석2009-2012년과민성자전(HSP)급자전성신염(HSPN)주원환인적발병정황,료해기재강서지구적류행특정.방법 이용2009-2012년재강서성인동의원주원적HSP화HSPN환인병안수혈신식자료,분석불동지구、불동시간、불동성별화년령적발병정황급기변화,동시여기타지구적발병정황진행비교,채용x2검험진행통계분석.결과 2009-2012년신발HSP주원환인2516례,각년도의차위412、568、750、786례；기중진단HSPN환인분별위110、148、198、196례,년평균신장수루솔위25.91％(652/2516).각년도신손해발생솔비교차이무통계학의의(x2=0.62,P＞0.05).HSP남녀성별비위1.59∶1,4～9세조65.50％(1648/2516),위발병고봉년령단.불동성별조HSP신장수루솔차이무통계학의의(x2=0.14,P＞0.05)；불동년령단HSP신장수루솔불동,분별위＜6세조18.76％(163/869)、6～11세조26.85％(359/1337)、≥11세조41.94％(130/310),각조비교차이유통계학의의(x2=65.24,P＜0.01).불동월빈HSP발병솔유차별,매년10월지12월위발병고봉,점신발병례40.74％(1025/2516).불동월빈HSP신장수루솔불동,1월지3월HSPN발생솔30.23％(208/688)고우기타월빈,각조차이유통계학의의(x2=9.87,P＜O.05).근4년강서성각지구HSP주원환자수:남창지구824례(32.75％)、비남창지구1692례(67.25％),남창지구HSP신장수루솔17.35％(143/824)저우각지평균치25.91％(652/2516),2조비교차이유통계학의의(x2=25.08,P＜0.01).결론 본지구HSP발병수축년증가,발병고봉위매년10월지12월,4～9세위발병고봉년령단.HSPN재1월지3월발생솔고우기타월빈,수착년령증장HSP루급신장적비솔축 점 증 가 .
Objective To analyze the incidence of hospitalized children with Henoch-Sch(o)nle in purpura (HSP) and Henoch-Sch(o)nlein purpura nephritis (HSPN) from 2009 to 2012,and to characterize the epidemiology of HSP and HSPN in Jiangxi province.Methods Inpatients of Jiangxi Children's Hospital with the diagnosis of HSP or HSPN were recruited during 2009 to 2012.The basic messages in the home page of medical records,such as the admission year,sex,age,area coming from were collected.Chi-square test was used for statistical analysis.Results A total of 2516 HSP pediatric patients were included in this study.Of whom,412 cases were diagnosed in 2009,568 cases in 2010,750 cases in 2011,786 cases in 2012.Among them,renal damage as the presenting symptom in 110 cases in 2009,148 cases in 2010,198 cases in 2011,and 196 cases in 2012.The average incidence of HSPN was 25.91％ (652/2516).The morbidity of HSPN were similar in different admission years (x2=0.62,P＞0.05).In HSP patients,the ratio between male and female was 1.59∶1; the peak age was 4 to 9 year-old (65.50％,1648/2516).The morbidity of HSPN was similar in both girls and boy patients group (x2=0.14,P＞0.05).The morbidity of HSPN was 18.76％ (163/869) in patients younger than 6 years old,which was lower than 26.85％(359/1337) in patients between age 6 to 11 years old,and the morbidity of HSPN was 41.94％ (130/310) in patients older than 11years old,the difference was significant (x2=65.24,P＜0.01).The morbidity of HSP in the month of year was different,the peak time was between October and December,which as 40.74％(1025/2516).The morbidity of HSPN was 30.23％(208/688) during January to March,higher than in other period of the year (x2=9.87,P＜0.05).In the last four years,there were 824(32.75％) hospitalized patients of HSP in Nanchang district,1692 cases (67.25％) in other areas in Jiangxi province.The morbidity of HSPN in Nanchang district was 17.35％ (143/824),compared with the average level 25.91％(652/2516),the difference was significant (x2=25.08,P＜0.01).Conclusion The number of children diagnosed with HSP is progressively increased from 2009 to 2012 in Jiangxi province.The peak period for HSP is between October and December,and the peak age is 4 to 9 year-old.The incidence of HSPN between January to March group is higher than in other periodof the year.The morbidity of HSPN is increased with age.