中华风湿病学杂志
中華風濕病學雜誌
중화풍습병학잡지
CHINESE JOURNAL OF RHEUMATOLOGY
2014年
1期
45-47
,共3页
张榕%郝丽敏%宋良月%左大辰%肖卫国
張榕%郝麗敏%宋良月%左大辰%肖衛國
장용%학려민%송량월%좌대신%초위국
肝硬化,胆汁性%半乳糖凝集素3
肝硬化,膽汁性%半乳糖凝集素3
간경화,담즙성%반유당응집소3
Liver cirrhosis,biliary%Galectin 3
目的 探讨半乳糖凝集素-3(Gal-3)在PBC发病机制中的作用.方法 比较72例不同病期PBC患者的临床指标,应用ELISA检测72例PBC患者及20名健康对照者Gal-3血清水平.采用t检验、方差分析、LSD-t检验与Pearson相关分析进行统计学分析.结果 PBC患者血清Gal-3水平高于健康对照组[(855±634) pg/ml与(463±446) pg/ml,R＜0.05],此外,随着病情进展PBC患者Gal-3水平、血小板、血红蛋白、白蛋白、IgM及补体C3水平逐渐降低,总胆红素水平升高(P＜0.05),PBC患者Gal-3水平与IgM及补体C3呈正相关(r=0.330,P=0.005;r=-0.357,P=0.002),与总胆红素呈负相关(r=-0.350,P=-0.003).结论 Gal-3可能参与PBC的免疫炎症损伤及肝纤维化的形成,Gal-3、血小板、血红蛋白、白蛋白、IgM、补体C3及总胆红素水平可作为判断病情轻重的指标.
目的 探討半乳糖凝集素-3(Gal-3)在PBC髮病機製中的作用.方法 比較72例不同病期PBC患者的臨床指標,應用ELISA檢測72例PBC患者及20名健康對照者Gal-3血清水平.採用t檢驗、方差分析、LSD-t檢驗與Pearson相關分析進行統計學分析.結果 PBC患者血清Gal-3水平高于健康對照組[(855±634) pg/ml與(463±446) pg/ml,R＜0.05],此外,隨著病情進展PBC患者Gal-3水平、血小闆、血紅蛋白、白蛋白、IgM及補體C3水平逐漸降低,總膽紅素水平升高(P＜0.05),PBC患者Gal-3水平與IgM及補體C3呈正相關(r=0.330,P=0.005;r=-0.357,P=0.002),與總膽紅素呈負相關(r=-0.350,P=-0.003).結論 Gal-3可能參與PBC的免疫炎癥損傷及肝纖維化的形成,Gal-3、血小闆、血紅蛋白、白蛋白、IgM、補體C3及總膽紅素水平可作為判斷病情輕重的指標.
목적 탐토반유당응집소-3(Gal-3)재PBC발병궤제중적작용.방법 비교72례불동병기PBC환자적림상지표,응용ELISA검측72례PBC환자급20명건강대조자Gal-3혈청수평.채용t검험、방차분석、LSD-t검험여Pearson상관분석진행통계학분석.결과 PBC환자혈청Gal-3수평고우건강대조조[(855±634) pg/ml여(463±446) pg/ml,R＜0.05],차외,수착병정진전PBC환자Gal-3수평、혈소판、혈홍단백、백단백、IgM급보체C3수평축점강저,총담홍소수평승고(P＜0.05),PBC환자Gal-3수평여IgM급보체C3정정상관(r=0.330,P=0.005;r=-0.357,P=0.002),여총담홍소정부상관(r=-0.350,P=-0.003).결론 Gal-3가능삼여PBC적면역염증손상급간섬유화적형성,Gal-3、혈소판、혈홍단백、백단백、IgM、보체C3급총담홍소수평가작위판단병정경중적지표.
Objective To investigate the effect of galectin-3 (Gal-3) on the pathogenesis of primary biliary cirrhosis (PBC).Methods The clinic data of 72 PBC patients at different stages were analyzed and the serum levels of Gal-3 were detected in 72 PBC patients and 20 controls by enzyme linked immunosorbent assay (ELISA).Independent t-test,variance analysis,LSD-t and Pearson correlation analysis were adopted for data analysis.Results The serum Gal-3 levels were significantly higher in PBC patients than those of healthy controls [(855±634) pg/ml,(463±446) pg/ml,P＜0.05].With the progression of disease,the levels of Gal-3,platelets,hemoglobin,albumin,IgM and complement C3 gradually declined,but the level of total bilirubin gradually elevated(P＜0.05).There was positive correlation between Gal-3 and immunoglobin IgM,complement C3 levels (r=0.330,P=0.005; r=0.357,P=0.002).There was negative correlation between Gal-3 and total bilirubin levels (r=0.350,P=0.003).Conclusion The Gal-3 can participate in the immune-mediated inflammation of PBC and the formation of liver fibrosis.The levels of Gal-3,platelet count,hemoglobin,albumin,IgM,complement C3 and total bilirubin could be regarded as laboratory parameters for the evaluation of the disease severity and prognosis.
