中华风湿病学杂志
中華風濕病學雜誌
중화풍습병학잡지
CHINESE JOURNAL OF RHEUMATOLOGY
2014年
9期
632-636
,共5页
高尿酸血症%儿童,住院%婴儿,新生儿%生化指标
高尿痠血癥%兒童,住院%嬰兒,新生兒%生化指標
고뇨산혈증%인동,주원%영인,신생인%생화지표
Hyperuricemia%Child,hospitalized%Infant,newborn%Biochemical parameters
目的 探讨住院儿童高尿酸血症水平的分布及其与反映器官损害的生化指标的关联性.方法 回顾性收集2012年6月至2013年10月在浙江省宁波市妇女儿童医院儿内科病房住院的检测过血清尿酸的患儿共23 217例,采用日本Olympus AU 2700生化分析仪检测血生化,其中尿酸酶-过氧化物酶偶联法检测血清尿酸.记录所有患儿的性别、年龄、主要诊断、尿酸水平,其中尿酸水平超过正常范围的患儿2 099例,运用x2检验比较不同组别高尿酸血症发生率.记录高尿酸血症患儿的各项血生化指标,运用Spearman秩相关对记录生化指标完整的1 650例患儿的血清尿酸与其余各项血生化指标进行相关性分析.结果 ①本院住院儿童高尿酸血症发生率为9.04％(2 099/23 217),其中男性6.51％(890/13 657),女性12.65％(1 209/9 560),性别差异有统计学意义(x2=256.9,P＜0.05).②将所有患儿按主要诊断所属系统不同分类,不同系统疾病高尿酸血症发生率依次为危重症36.93％(113/306),新生儿疾病20.34％(922/4 533),泌尿系统疾病12.08％ (47/389),循环系统疾病11.67％(21/180),神经系统疾病11.05％(112/1 014),消化系统疾病10.50％(190/1 810),感染性疾病10.18％(120/1 179),血液系统疾病7.58％(55/726),内分泌系统疾病5.74％(17/296),自身免疫病4.24％(48/1 131),呼吸系统疾病3.90％(454/11 653),差异有统计学意义(x2=1423.0,P＜0.05).③各年龄组高尿酸血症发生率分别为～1个月18.31％(925/5 075),～1岁4.22％(359/8 501),～6岁10.68％ (600/5 618),～15岁5.24％ (211/4 023),差异有统计学意义(x2=858.5,P＜0.05),两两比较差异均有统计学意义(P均＜0.05).④血清尿酸水平与反映肾功能的尿素氮、肌酐及反映心功能的乳酸脱氢酶、α-羟丁酸脱氢酶、CK、CK-MB同工酶水平均呈正相关(r=0.426、0.44、0.324、0.367、0.413、0.431,P均＜0.05).⑤血清尿酸水平与果糖胺、血糖、甘油三酯、总胆固醇、LDL-C 、HDL-C均无相关.结论 高尿酸血症在住院儿童中的发生率不低,在新生儿及重症患儿最高,其次是泌尿系统及循环系统疾病患儿中,儿童高尿酸血症与心、肾等器官损害的血生化指标有一定相关性.
目的 探討住院兒童高尿痠血癥水平的分佈及其與反映器官損害的生化指標的關聯性.方法 迴顧性收集2012年6月至2013年10月在浙江省寧波市婦女兒童醫院兒內科病房住院的檢測過血清尿痠的患兒共23 217例,採用日本Olympus AU 2700生化分析儀檢測血生化,其中尿痠酶-過氧化物酶偶聯法檢測血清尿痠.記錄所有患兒的性彆、年齡、主要診斷、尿痠水平,其中尿痠水平超過正常範圍的患兒2 099例,運用x2檢驗比較不同組彆高尿痠血癥髮生率.記錄高尿痠血癥患兒的各項血生化指標,運用Spearman秩相關對記錄生化指標完整的1 650例患兒的血清尿痠與其餘各項血生化指標進行相關性分析.結果 ①本院住院兒童高尿痠血癥髮生率為9.04％(2 099/23 217),其中男性6.51％(890/13 657),女性12.65％(1 209/9 560),性彆差異有統計學意義(x2=256.9,P＜0.05).②將所有患兒按主要診斷所屬繫統不同分類,不同繫統疾病高尿痠血癥髮生率依次為危重癥36.93％(113/306),新生兒疾病20.34％(922/4 533),泌尿繫統疾病12.08％ (47/389),循環繫統疾病11.67％(21/180),神經繫統疾病11.05％(112/1 014),消化繫統疾病10.50％(190/1 810),感染性疾病10.18％(120/1 179),血液繫統疾病7.58％(55/726),內分泌繫統疾病5.74％(17/296),自身免疫病4.24％(48/1 131),呼吸繫統疾病3.90％(454/11 653),差異有統計學意義(x2=1423.0,P＜0.05).③各年齡組高尿痠血癥髮生率分彆為～1箇月18.31％(925/5 075),～1歲4.22％(359/8 501),～6歲10.68％ (600/5 618),～15歲5.24％ (211/4 023),差異有統計學意義(x2=858.5,P＜0.05),兩兩比較差異均有統計學意義(P均＜0.05).④血清尿痠水平與反映腎功能的尿素氮、肌酐及反映心功能的乳痠脫氫酶、α-羥丁痠脫氫酶、CK、CK-MB同工酶水平均呈正相關(r=0.426、0.44、0.324、0.367、0.413、0.431,P均＜0.05).⑤血清尿痠水平與果糖胺、血糖、甘油三酯、總膽固醇、LDL-C 、HDL-C均無相關.結論 高尿痠血癥在住院兒童中的髮生率不低,在新生兒及重癥患兒最高,其次是泌尿繫統及循環繫統疾病患兒中,兒童高尿痠血癥與心、腎等器官損害的血生化指標有一定相關性.
목적 탐토주원인동고뇨산혈증수평적분포급기여반영기관손해적생화지표적관련성.방법 회고성수집2012년6월지2013년10월재절강성저파시부녀인동의원인내과병방주원적검측과혈청뇨산적환인공23 217례,채용일본Olympus AU 2700생화분석의검측혈생화,기중뇨산매-과양화물매우련법검측혈청뇨산.기록소유환인적성별、년령、주요진단、뇨산수평,기중뇨산수평초과정상범위적환인2 099례,운용x2검험비교불동조별고뇨산혈증발생솔.기록고뇨산혈증환인적각항혈생화지표,운용Spearman질상관대기록생화지표완정적1 650례환인적혈청뇨산여기여각항혈생화지표진행상관성분석.결과 ①본원주원인동고뇨산혈증발생솔위9.04％(2 099/23 217),기중남성6.51％(890/13 657),녀성12.65％(1 209/9 560),성별차이유통계학의의(x2=256.9,P＜0.05).②장소유환인안주요진단소속계통불동분류,불동계통질병고뇨산혈증발생솔의차위위중증36.93％(113/306),신생인질병20.34％(922/4 533),비뇨계통질병12.08％ (47/389),순배계통질병11.67％(21/180),신경계통질병11.05％(112/1 014),소화계통질병10.50％(190/1 810),감염성질병10.18％(120/1 179),혈액계통질병7.58％(55/726),내분비계통질병5.74％(17/296),자신면역병4.24％(48/1 131),호흡계통질병3.90％(454/11 653),차이유통계학의의(x2=1423.0,P＜0.05).③각년령조고뇨산혈증발생솔분별위～1개월18.31％(925/5 075),～1세4.22％(359/8 501),～6세10.68％ (600/5 618),～15세5.24％ (211/4 023),차이유통계학의의(x2=858.5,P＜0.05),량량비교차이균유통계학의의(P균＜0.05).④혈청뇨산수평여반영신공능적뇨소담、기항급반영심공능적유산탈경매、α-간정산탈경매、CK、CK-MB동공매수평균정정상관(r=0.426、0.44、0.324、0.367、0.413、0.431,P균＜0.05).⑤혈청뇨산수평여과당알、혈당、감유삼지、총담고순、LDL-C 、HDL-C균무상관.결론 고뇨산혈증재주원인동중적발생솔불저,재신생인급중증환인최고,기차시비뇨계통급순배계통질병환인중,인동고뇨산혈증여심、신등기관손해적혈생화지표유일정상관성.
Objective To explore the correlation between the distribution of uric acid (UA) level and the biochemical indicators which reflect the degree of organ lesions among hospitalized children.Methods Patients who were hospitalized to the Department of Pediatrics and received the blood UA test from June 2012 to October 2013 were included,23 217 cases in total.The biochemical analyzer-Japan's Olympus AU 2700 was used to detect blood biochemistry; and uricase-peroxidase coupling method was used to detect blood UA.Among these patients,2 099 cases whose UA level exceeded the normal level.Then the patients' gender,age,primary diagnosis and UA level were recorded; and the distribution of their UA level was described.The Chi-square or Fisher test was used to assess the incidence rate.At the same time,each blood biochemical indicators of the patients with high UA level were recorded ; and the relationships between the blood UA of the 1 650 patients with complete records and each blood biochemical indicator were analyzed with Pearson correlation analysis.Results The incidence rate of hyperuricemia among the hospitalized children was 9.04％(2 099/23 217).In particular,the incidence rate among boys and girls was 6.5t％(890/13 657) and 12.65％ (1 209/9 560) respectively (x2 =256.9,P＜0.05).The incidence rate of hyperuricemiin different diseases was as follows:in the critical illness 36.93％ (113/306),neonatal disease 20.34％ (922/4 533),urinary system diseases 12.08％ (47/389),circulatory system diseases 11.67％ (21/180),nervous system diseases 11.05％(112/1 014),digestive diseases 10.50％(190/1 810),infectious diseases 10.18％(120/1 179),blood diseases 7.58％ (55/726),endocrine system diseases 5.74％ (17/296),autoimmune diseases 4.24％ (48/1 131),respiratory diseases 3.90％ (454/11 653) respectively (x2=1423.0,P＜0.05).The incidence of hyperuricemia at younger than one month was 18.31％(929/5 075),younger than one year old was 4.22％ (359/8 501),younger than six years old was 10.68％(600/5 618),younger than 15 years old was 5.24％ (211/4 023) respectively (x2=858.5,P＜0.05).Blood UA was positively correlated to urea nitrogen,creatinine,lacticdehydrogenase,α-hydroxy-butyrate dehydrogenase,creatine kinase and creatine kinase-MB (r=0.426,0.44,0.324,0.367,0.413,0.431,P＜0.05).Blood UA was not correlated to fructosamine,blood glucose,triglycerides,total cholesterol,low-density lipoprotein and high density lipoprotein.Conclusion The incidence of hyper-uricemia among hospitalized children is high; and the incidence among children with severe diseases and newborn babies is high; followed by in children with urinary system and circulatory system diseases.The blood UA level is closely related to the blood biochemical indicators which reflect the lesions of heart and kidney.
