CAJ | 학술논문

目的探讨DM患者血清B细胞活化因子(BAFF)水平与疾病活动度的相关性.方法定量ELISA方法检测61例DM患者以及25名健康对照血清BAFF浓度;利用国际肌炎组织制定的炎性肌病评价工具评估DM患者疾病活动度,并分析血清BAFF水平与DM疾病活动度的相关性.组间比较用独立Mann-WhitneyU检验,相关性分析采用Spearman秩检验.结果横断面研究显示DM患者血清BAFF水平显著高于健康对照[(274 7±264 6)pg/ml与(832±170) pg/ml,Z=-5.492,P＜0.01];DM患者血清BAFF浓度与疾病总活动度(r=0.501,P＜0.001)、肌肉活动度(r=0.303,P＜0.05)、皮肤黏膜活动度(r=0.467,P＜0.01)呈显著正相关;血清BAFF水平升高与DM患者肺间质病变的发生具有显著相关性(x2=17.238,P＜0.01).纵向研究同样显示DM患者血清BAFF浓度与疾病总活动度(r=0.658,P＜0.01)、肌肉活动度(r=0.307,P＜0.05)、皮肤黏膜活动度(r=0.565,P＜0.01)呈正相关.DM患者治疗后,随着疾病活动度的下降,血清BAFF水平显著降低.结论 DM患者血清BAFF水平与疾病活动度呈正相关性,血清BAFF是反映DM患者疾病活动度的生物标记物.
목적 탐토DM환자혈청B세포활화인자(BAFF)수평여질병활동도적상관성.방법 정량ELISA방법검측61례DM환자이급25명건강대조혈청BAFF농도;이용국제기염조직제정적염성기병평개공구평고DM환자질병활동도,병분석혈청BAFF수평여DM질병활동도적상관성.조간비교용독립Mann-WhitneyU검험,상관성분석채용Spearman질검험.결과 횡단면연구현시DM환자혈청BAFF수평현저고우건강대조[(274 7±264 6)pg/ml여(832±170) pg/ml,Z=-5.492,P＜0.01];DM환자혈청BAFF농도여질병총활동도(r=0.501,P＜0.001)、기육활동도(r=0.303,P＜0.05)、피부점막활동도(r=0.467,P＜0.01)정현저정상관;혈청BAFF수평승고여DM환자폐간질병변적발생구유현저상관성(x2=17.238,P＜0.01).종향연구동양현시DM환자혈청BAFF농도여질병총활동도(r=0.658,P＜0.01)、기육활동도(r=0.307,P＜0.05)、피부점막활동도(r=0.565,P＜0.01)정정상관.DM환자치료후,수착질병활동도적하강,혈청BAFF수평현저강저.결론 DM환자혈청BAFF수평여질병활동도정정상관성,혈청BAFF시반영DM환자질병활동도적생물표기물.
Objective To investigate the correlation between serum levels of B cell activating factor (BAFF) and disease activity in the patients with dermatomyositis (DM).Methods Serum BAFF levels of 61 patients with DM and 25 matched healthy controls were measured by ELISA.The results of the two groups were compared using unpaired Mann-Whitney U test and the relevance was analyzed using Spearman correlation analysis.Results Serum levels of BAFF in DM patients were significantly higher compared to healthy controls [(274 7±264 6) pg/ml 与 (832±170) pg/ml,Z=-5.492,P＜0.01].A cross-sectional assessment revealed that serum BAFF levels were positively correlated with global disease activity (r=0.501,P＜0.001),muscle disease activity (r=0.303,P＜0.05),and cutaneous disease activity (r=0.467,P＜0.01).High serum BAFF levels were associated with increased incidence of interstitial lung disease (x2=17.238,P＜0.01).The longitudinal study showed modest correlations between serum BAFF levels and global disease activity (r=0.658,P＜0.01),muscle disease activity (r=0.307,P＜0.05),as well as cutaneous disease activity (r=0.565,P＜0.01).Conclusion Serum levels of BAFF correlate with disease activity in DM patients.The results of this study suggest that BAFF is a serological biomarker for DM disease activity.