国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
6期
824-826
,共3页
林媚%关翠柳%张淑琨%苏丹梅
林媚%關翠柳%張淑琨%囌丹梅
림미%관취류%장숙곤%소단매
妥布霉素%氧氟沙星%细菌感染性小儿眼病%临床疗效
妥佈黴素%氧氟沙星%細菌感染性小兒眼病%臨床療效
타포매소%양불사성%세균감염성소인안병%림상료효
Tobramycin%Ofloxacin%Bacterial infection in pediatric eye disease%Clinical effect
目的 对比妥布霉素和常用治疗细菌感染性小儿外眼疾病药物的临床疗效,分析妥布霉素在细菌性感染小儿外眼疾病方面的应用安全性.方法 选取2011年3月至2013年3月期间在我院治疗的小儿细菌感染性外眼疾病患者155例作为研究对象.随即分为实验组和对照组,实验组患者采取妥布霉素进行治疗;对照组患者采取氧氟沙星进行治疗.对比两组治疗后的效果、细菌敏感情况、清除细菌率以及不良反应的发生情况.结果 实验组患者的临床总有效率为93.3％,对照组患者的总有效率为75.0％,两组比较差异具有统计学意义(P＜0.05).妥布霉素的细菌敏感度为92.0％,氧氟沙星的细菌敏感度为90.0％,两组比较差异无统计学意义(P＞0.05).妥布霉素的细菌清除率为95.2％,氧氟沙星的细菌清除率为73.5％,两组比较差异具有统计学意义(P＜0.05).实验组和对照组分别出现1例和15例眼部刺激疼痛的不良反应.结论 妥布霉素治疗细菌感染性小儿外眼疾病疗效比氧氟沙星显著,安全性比氧氟沙星高,具有更大的临床应用价值.
目的 對比妥佈黴素和常用治療細菌感染性小兒外眼疾病藥物的臨床療效,分析妥佈黴素在細菌性感染小兒外眼疾病方麵的應用安全性.方法 選取2011年3月至2013年3月期間在我院治療的小兒細菌感染性外眼疾病患者155例作為研究對象.隨即分為實驗組和對照組,實驗組患者採取妥佈黴素進行治療;對照組患者採取氧氟沙星進行治療.對比兩組治療後的效果、細菌敏感情況、清除細菌率以及不良反應的髮生情況.結果 實驗組患者的臨床總有效率為93.3％,對照組患者的總有效率為75.0％,兩組比較差異具有統計學意義(P＜0.05).妥佈黴素的細菌敏感度為92.0％,氧氟沙星的細菌敏感度為90.0％,兩組比較差異無統計學意義(P＞0.05).妥佈黴素的細菌清除率為95.2％,氧氟沙星的細菌清除率為73.5％,兩組比較差異具有統計學意義(P＜0.05).實驗組和對照組分彆齣現1例和15例眼部刺激疼痛的不良反應.結論 妥佈黴素治療細菌感染性小兒外眼疾病療效比氧氟沙星顯著,安全性比氧氟沙星高,具有更大的臨床應用價值.
목적 대비타포매소화상용치료세균감염성소인외안질병약물적림상료효,분석타포매소재세균성감염소인외안질병방면적응용안전성.방법 선취2011년3월지2013년3월기간재아원치료적소인세균감염성외안질병환자155례작위연구대상.수즉분위실험조화대조조,실험조환자채취타포매소진행치료;대조조환자채취양불사성진행치료.대비량조치료후적효과、세균민감정황、청제세균솔이급불량반응적발생정황.결과 실험조환자적림상총유효솔위93.3％,대조조환자적총유효솔위75.0％,량조비교차이구유통계학의의(P＜0.05).타포매소적세균민감도위92.0％,양불사성적세균민감도위90.0％,량조비교차이무통계학의의(P＞0.05).타포매소적세균청제솔위95.2％,양불사성적세균청제솔위73.5％,량조비교차이구유통계학의의(P＜0.05).실험조화대조조분별출현1례화15례안부자격동통적불량반응.결론 타포매소치료세균감염성소인외안질병료효비양불사성현저,안전성비양불사성고,구유경대적림상응용개치.
Objective To compare the clinical efficacy of tobramycin and commonly used drug in the treatment of bacterial infection in pediatric eye disease,and to analyze security of tobramycin in children with bacterial infection eye diseases.Methods From March 2011 to March 2013 155 children with bacterial infection eye diseases in our hospital were selected as object of study and randomly divided into experimental group and control group.Experimental group was treated with tobramycin,while control group was commonly treated with ofloxacin.Compared the efficacy,bacterial sensitivity,bacterial clearance rate and adverse reactions of two groups after treatment.Results The clinical total effective rate in experimental group was 93.3％,that in control group was 75.0％,with significant difference between two groups (P ＜ 0.05).The bacterial sensitivity of tobramycin was 92.0％,that of ofloxacin was 90.0％,without significant difference (P ＞ 0.05).The bacterial clearance rate of tobramvcin was 95.2％,that of ofloxacin was 73.5％,with significant difference (P ＜ 0.05).There was l case of ocular irritation pain in experimental group,and 15 cases in control group.Conclusion Tobramycin in the treatment of bacterial infection in children with eye disease is more effective than ofloxacin,with high security,worthy of clinical application.
