CAJ | 학술논문

目的评价埃索美拉唑联合莫沙必利治疗反流性食管炎的临床疗效.方法将2010年2月至2013年3月来我院就诊的32例反流性食管炎患者随机分为两组,其中观察组16例,采用埃索美拉唑联合莫沙必利治疗,对照组16例,采用奥美拉唑联合莫沙必利治疗.观察并比较两组患者的临床疗效.结果观察组总有效率为93.75％,对照组总有效率为81.25％,两组比较差异有统计学意义,P＜ 0.05;两组患者治疗前主要症状积分相比差异无统计学意义,经治疗后,反酸、烧心、下咽困难及胸骨后疼痛的症状积分均较治疗前明显改善(P＜0.05);观察组不良反应的发生率为6.25％,对照组不良反应的发生率为18.75％,差异有统计学意义,P＜0.05.结论埃索美拉唑联合莫沙必利治疗反流性食管炎疗效好,值得在临床上予以推广.
목적 평개애색미랍서연합막사필리치료반류성식관염적림상료효.방법 장2010년2월지2013년3월래아원취진적32례반류성식관염환자수궤분위량조,기중관찰조16례,채용애색미랍서연합막사필리치료,대조조16례,채용오미랍서연합막사필리치료.관찰병비교량조환자적림상료효.결과 관찰조총유효솔위93.75％,대조조총유효솔위81.25％,량조비교차이유통계학의의,P＜ 0.05;량조환자치료전주요증상적분상비차이무통계학의의,경치료후,반산、소심、하인곤난급흉골후동통적증상적분균교치료전명현개선(P＜0.05);관찰조불량반응적발생솔위6.25％,대조조불량반응적발생솔위18.75％,차이유통계학의의,P＜0.05.결론 애색미랍서연합막사필리치료반류성식관염료효호,치득재림상상여이추엄.
Objective To evaluate the efficacy of esomeprazole combined with mosapride in the treatment of reflux esophagitis.Methods From February 2010 to March 2013,32 patients with reflux esophagitis were randomly divided into two groups,16 cases in each group.Observation group received esomeprazole and mosapride,while control group received omeprazole and mosapride.The efficacy of two groups was observed and compared.Results The total effective rate in observation group was 93.75％,that in control group was 81.25％,with statistical significant difference (P ＜ 0.05).There was no statistical significant difference in major symptom score between two groups before treatment; after treatment,symptom scores of acid reflux,heartburn,swallowing difficulty and retrostemal pain improved significantly (P ＜ 0.05).The incidence of adverse reactions in observation group was 6.25％,that in control group was 18.75％,with statistical significant difference (P ＜ 0.05).Conclusion Esomeprazole combined with mosapride in the treatment of reflux esophagitis is effective,worthy of clinical promotion.