中华放射学杂志
中華放射學雜誌
중화방사학잡지
Chinese Journal of Radiology
2014年
9期
730-735
,共6页
夏爽%柴超%沈文%闫铄%张孟杰%卢光明
夏爽%柴超%瀋文%閆鑠%張孟傑%盧光明
하상%시초%침문%염삭%장맹걸%로광명
磁共振成像%铁%年龄因素%脑
磁共振成像%鐵%年齡因素%腦
자공진성상%철%년령인소%뇌
Magnetic resonance imaging%Iron%Age factors%Brain
目的 利用MR定量磁敏感图(QSM)对不同年龄正常人脑铁含量进行测量,观察其随年龄的变化趋势.方法 利用3.0T MR成像系统,对63名健康右利手志愿者行常规MRI和磁敏感加权成像(SWI)序列扫描,获得正常颅脑SWI未滤波相位图和幅度图,利用磁敏感图像成像与相位伪影消障工具(SMART)后处理软件对未滤波相位图和幅度图进行处理得到QSM,利用SPIN软件手工绘出磁敏感图中双侧额叶白质及灰质核团(尾状核、苍白球、壳核、背侧丘脑、红核、黑质及齿状核)的ROI,测量ROI的磁敏感值,并与Hallgren和Sourander对尸体脑组织染色所得铁含量的结果进行线性相关分析,观察两者的一致性.采用秩和检验比较不同侧别和性别间额叶白质及灰质核团间的磁敏感值的差异.利用Spearman相关分析其与年龄的相关性.结果 63名健康志愿者额叶白质、尾状核、苍白球、壳核、背侧丘脑、黑质、红核及齿状核磁敏感值的中位数(范围)分别为-12.81(-31.56,8.72)、39.27 (22.35,75.13)、93.99 (19.19,158.75)、29.16(4.11,81.53)、2.91(-27.80,27.95)、83.14 (38.57,185.79)、63.49(13.83,142.09)、63.30(36.78,128.53)ppb(×10-9),与Hallgren和Sourander的结果具有很高的一致性(r=0.91,P＜0.05).苍白球的磁敏感值最高,其次为黑质;额叶白质的磁敏感值最低.右侧尾状核、黑质、红核及齿状核的磁敏感值高于左侧,差异有统计学意义(Z值分别-3.18、-4.44、-3.70、-2.64,P值均＜0.05).男性左右侧苍白球磁敏感值与女性差异有统计学意义(Z值分别为-2.27、-2.42,P值均＜0.05).双侧尾状核、壳核、红核、齿状核磁敏感值均与年龄具有相关性(r值为0.30～0.49,P值均＜0.05).结论 QSM能清晰显示脑内核团;QSM能较准确评估脑内的铁含量,与组织病理学结果评估脑内铁含量具有较高一致性;双侧尾状核、壳核、红核、齿状核的铁含量随年龄的变化具有增加的趋势.
目的 利用MR定量磁敏感圖(QSM)對不同年齡正常人腦鐵含量進行測量,觀察其隨年齡的變化趨勢.方法 利用3.0T MR成像繫統,對63名健康右利手誌願者行常規MRI和磁敏感加權成像(SWI)序列掃描,穫得正常顱腦SWI未濾波相位圖和幅度圖,利用磁敏感圖像成像與相位偽影消障工具(SMART)後處理軟件對未濾波相位圖和幅度圖進行處理得到QSM,利用SPIN軟件手工繪齣磁敏感圖中雙側額葉白質及灰質覈糰(尾狀覈、蒼白毬、殼覈、揹側丘腦、紅覈、黑質及齒狀覈)的ROI,測量ROI的磁敏感值,併與Hallgren和Sourander對尸體腦組織染色所得鐵含量的結果進行線性相關分析,觀察兩者的一緻性.採用秩和檢驗比較不同側彆和性彆間額葉白質及灰質覈糰間的磁敏感值的差異.利用Spearman相關分析其與年齡的相關性.結果 63名健康誌願者額葉白質、尾狀覈、蒼白毬、殼覈、揹側丘腦、黑質、紅覈及齒狀覈磁敏感值的中位數(範圍)分彆為-12.81(-31.56,8.72)、39.27 (22.35,75.13)、93.99 (19.19,158.75)、29.16(4.11,81.53)、2.91(-27.80,27.95)、83.14 (38.57,185.79)、63.49(13.83,142.09)、63.30(36.78,128.53)ppb(×10-9),與Hallgren和Sourander的結果具有很高的一緻性(r=0.91,P＜0.05).蒼白毬的磁敏感值最高,其次為黑質;額葉白質的磁敏感值最低.右側尾狀覈、黑質、紅覈及齒狀覈的磁敏感值高于左側,差異有統計學意義(Z值分彆-3.18、-4.44、-3.70、-2.64,P值均＜0.05).男性左右側蒼白毬磁敏感值與女性差異有統計學意義(Z值分彆為-2.27、-2.42,P值均＜0.05).雙側尾狀覈、殼覈、紅覈、齒狀覈磁敏感值均與年齡具有相關性(r值為0.30～0.49,P值均＜0.05).結論 QSM能清晰顯示腦內覈糰;QSM能較準確評估腦內的鐵含量,與組織病理學結果評估腦內鐵含量具有較高一緻性;雙側尾狀覈、殼覈、紅覈、齒狀覈的鐵含量隨年齡的變化具有增加的趨勢.
목적 이용MR정량자민감도(QSM)대불동년령정상인뇌철함량진행측량,관찰기수년령적변화추세.방법 이용3.0T MR성상계통,대63명건강우리수지원자행상규MRI화자민감가권성상(SWI)서렬소묘,획득정상로뇌SWI미려파상위도화폭도도,이용자민감도상성상여상위위영소장공구(SMART)후처리연건대미려파상위도화폭도도진행처리득도QSM,이용SPIN연건수공회출자민감도중쌍측액협백질급회질핵단(미상핵、창백구、각핵、배측구뇌、홍핵、흑질급치상핵)적ROI,측량ROI적자민감치,병여Hallgren화Sourander대시체뇌조직염색소득철함량적결과진행선성상관분석,관찰량자적일치성.채용질화검험비교불동측별화성별간액협백질급회질핵단간적자민감치적차이.이용Spearman상관분석기여년령적상관성.결과 63명건강지원자액협백질、미상핵、창백구、각핵、배측구뇌、흑질、홍핵급치상핵자민감치적중위수(범위)분별위-12.81(-31.56,8.72)、39.27 (22.35,75.13)、93.99 (19.19,158.75)、29.16(4.11,81.53)、2.91(-27.80,27.95)、83.14 (38.57,185.79)、63.49(13.83,142.09)、63.30(36.78,128.53)ppb(×10-9),여Hallgren화Sourander적결과구유흔고적일치성(r=0.91,P＜0.05).창백구적자민감치최고,기차위흑질;액협백질적자민감치최저.우측미상핵、흑질、홍핵급치상핵적자민감치고우좌측,차이유통계학의의(Z치분별-3.18、-4.44、-3.70、-2.64,P치균＜0.05).남성좌우측창백구자민감치여녀성차이유통계학의의(Z치분별위-2.27、-2.42,P치균＜0.05).쌍측미상핵、각핵、홍핵、치상핵자민감치균여년령구유상관성(r치위0.30～0.49,P치균＜0.05).결론 QSM능청석현시뇌내핵단;QSM능교준학평고뇌내적철함량,여조직병이학결과평고뇌내철함량구유교고일치성;쌍측미상핵、각핵、홍핵、치상핵적철함량수년령적변화구유증가적추세.
Objective To evaluate the distribution and age-related changes of brain iron content in healthy people using MR quantitative susceptibility mapping (QSM).Methods Sixty three healthy right-handed volunteers underwent the routine MRI and SWI scan to get SWI-unfiltered phase images and magnitude images.QSM were reconstructed from the SWI-unfiltered phase images and magnitude images using SMART software.The regions of interest at the bilateral frontal white matter and nuclei (caudate nuclews,globus pallidus,putamen,substantia nigra,dorsal thalamus,red nucleus and dental nucleus) were drawn manually,and the susceptibility was measured.The linear correlation between the susceptibility and iron concentration cited from Hallgren and Sourander's post-mortem brain study was calculated.Wilcoxon test were applied to calculate the difference between the bilateral frontal white matter and bilateral nuclei.The correlation of age with susceptibility of bilateral frontal white matter and bilateral nuclei were analyzed by Spearman correlation analysis.Results The median susceptibility (extent) of frontal white matter,caudate nucleus,globus pallidus,putamen,dorsal thalamus,substantia nigra,red nucleus and dentate nucleus of 63 healthy people were-12.81 (-31.56,8.72),39.27 (22.35,75.13),93.99 (19.19,158.75),29.16 (4.11,81.53),2.91 (-27.80,27.95),83.14 (38.57,185.79),63.49 (13.83,142.09),63.30 (36.78,128.53) ppb (× 10-9),respectively.There was high consistency with Hallgren and Sourander's study (r=0.91,P＜0.05).The susceptibility of globus pallidus was the highest,followed by substantia nigra.The least susceptibility was seen in the frontal white matter.The susceptibility of right caudate nucleus,substantia nigra,red nucleus and dental nucleus was higher than that of left side (Z value was-3.18,-4.44,-3.70 and-2.64,respectively,P＜0.05).The susceptibility of bilateral globus pallidus of the male was significantly different from that of the female (Z value was-2.27 and-2.42,respectively,P＜0.05).There was positive correlation between age and the susceptibility of bilateral caudate nucleus,putamen,red nucleus and dental nucleus (r value was 0.30 to 0.49,P＜0.05).Conclusions QSM based on the SWI-unfiltered phase and magnitude images can clearly display the cerebral nuclei and evaluate the brain iron content accurately,which is consistent with the histopathological results.Iron content of bilateral caudate nucleus,putamen,red nucleus and dental nucleus increase with aging.
