CAJ | 학술논문

目的采用计算生物等效剂量(BED)值的方法,对头颈部肿瘤非常规分割放疗方案进行分析,从BED值变化规律的角度来分析各种不同分割治疗方法的优劣.方法针对Cochrane协作网在2010年公布的一项关于头颈部肿瘤非常规分割治疗的调查报告中所列举的常规分割和非常规分割治疗方案,使用L-Q模型计算BED值,分析不同治疗方案的BED值随时间的累积变化规律.结果在总剂量统一为70 Gy的前提下,常规分割方案尤其是超分割治疗方案,可以在较短时间内集中给予肿瘤组织较大的BED值；超分割治疗可以有效地降低晚反应组织累计的BED值；分段超分割治疗方案在保证肿瘤组织获得较大BED值的同时,可以有效地降低早反应组织在治疗过程中累计的BED值.结论使用L-Q模型计算BED值的方法对不同治疗方案进行分析,观察BED值随治疗过程的变化规律,通过数学模型评价不同的放疗分割方案,对临床选择肿瘤治疗方案起到指导作用.
목적 채용계산생물등효제량(BED)치적방법,대두경부종류비상규분할방료방안진행분석,종BED치변화규률적각도래분석각충불동분할치료방법적우렬.방법 침대Cochrane협작망재2010년공포적일항관우두경부종류비상규분할치료적조사보고중소열거적상규분할화비상규분할치료방안,사용L-Q모형계산BED치,분석불동치료방안적BED치수시간적루적변화규률.결과 재총제량통일위70 Gy적전제하,상규분할방안우기시초분할치료방안,가이재교단시간내집중급여종류조직교대적BED치；초분할치료가이유효지강저만반응조직루계적BED치；분단초분할치료방안재보증종류조직획득교대BED치적동시,가이유효지강저조반응조직재치료과정중루계적BED치.결론 사용L-Q모형계산BED치적방법대불동치료방안진행분석,관찰BED치수치료과정적변화규률,통과수학모형평개불동적방료분할방안,대림상선택종류치료방안기도지도작용.
Objective To analyze the advantage of altered fractionation radiotherapy by calculating the accumulative effects of daily biologically effective dose (BED) to find out the difference between conventional fractionated radiotherapy and altered fractionation radiotherapy.Methods The data in the report of hyperfractionated or accelerated radiotherapy for head and neck cancer published by Cochrane Collaboration in 2010 was analyzed.Based on the radiotherapy processes mentioned in this report,the accumulative effects of daily BED were calculated and compared in different radiotherapy processes by using linear-quadratic mode.The variation of BED in different radiotherapy processes was find out.Results In total dose of unity as the premise of 70 Gy,altered fractionation especially the hyperfractionated accelerated radiotherapy could give a higher BED to the tumor during a shorter period,hyperfractionated radiotherapy could give a lower BED to normal tissues,and hyperfractionated radiotherapy with split course could give higher BED to the tumor while lower BED to normal tissues.Conclusions The variation of BED in different radiotherapy processes can be shown clearly by linear-quadratic mode.It can be simple and shortcut through mathematical models for the evaluation of different radiotherapy plan,on clinical symptomatic selection play a guiding role in tumor therapy.