CAJ | 학술논문

目的探讨自体干细胞移植预处理方案中使用全身放射治疗(TBI)对造血重建的影响及其短期不良反应.方法对1990-2012年的103例自体干细胞移植患者进行回顾性分析,根据预处理方案不同分为TBI组和NTBI组(不含全身照射),比较两组造血重建的差异,及其相关短期不良反应的异同.结果两组中性粒细胞植活中位时间均为12d,TBI组血小板植活中位时间为11d,而NTBI组为10.5d,两组间差异无统计学意义,在短期不良反应上TBI组的口腔黏膜炎、胃肠道反应的发生率高于NTBI组(x2=6.458、22.400,P＜0.05),而在感染等方面两组差异无统计学意义.结论预防治疗后TBI做为预处理方案较NTBI组未见较为严重的短期不良反应,有较好的耐受性.
목적 탐토자체간세포이식예처리방안중사용전신방사치료(TBI)대조혈중건적영향급기단기불량반응.방법 대1990-2012년적103례자체간세포이식환자진행회고성분석,근거예처리방안불동분위TBI조화NTBI조(불함전신조사),비교량조조혈중건적차이,급기상관단기불량반응적이동.결과 량조중성립세포식활중위시간균위12d,TBI조혈소판식활중위시간위11d,이NTBI조위10.5d,량조간차이무통계학의의,재단기불량반응상TBI조적구강점막염、위장도반응적발생솔고우NTBI조(x2=6.458、22.400,P＜0.05),이재감염등방면량조차이무통계학의의.결론 예방치료후TBI주위예처리방안교NTBI조미견교위엄중적단기불량반응,유교호적내수성.
Objective To explore the influence of TBI in the conditioning regimen for autologous stem cell transplantation,as well as short-term side-effects.Methods To tally 103 patients were divided into TBI group and no TBI group with autologous stem cell transplantation during 1990-2012.The time required for hematopoietic reconstitution and the short-term side effects were analyzed.Results Between the two groups,the hematopoietic reconstitution time had no significant difference,but there was a high incidence of oral mucositis and gastrointestinal reaction in the TBI group (x2 =6.458,22.400,P ＜0.05),and the incidence of infection is not significant.Conclusions Given the preventive treatment,the TBI group has no more serious short-term side effects and better tolerance.