CAJ | 학술논문

目的观察比较不同分割方案对人脑胶质瘤裸小鼠移植瘤亚临床肿瘤的剂量效应关系,筛选分割照射的优化方案.方法采用人脑胶质母细胞瘤裸小鼠移植瘤亚临床肿瘤为实验模型进行不同总剂量(40、60 Gy)、不同分割方案(200 cGy5次/周、160 cGy2次/d、300 cGy5次/周和400cGy3次/周)及靶向药泰欣生联合常规分割照射.观察指标为成瘤率、肿瘤复发时间及肿瘤基底最大径,总观察时间为24周.结果总剂量40 Gy时大分割组近期疗效较好(400 cGy3次/周疗程结束时成瘤率为0),无论采用何种分割方案均未能阻断肿瘤持续生长.总剂量60 Gy时常规分割的控制效果最差(成瘤率为100％),超分割方案的效果相对最好(远期控制为25％),其次为300 cGy5次/周(远期控制为12.5％),400 cGy3次/周相对较差(近期控制较远期好).靶向药泰欣生联合常规分割60 Gy照射无改善作用.结论对控制恶性脑胶质瘤亚临床肿瘤常规分割模式尚不是一个优化方案,超分割160 cGy2次/d和300 cGy5次/周是相对优化方案.
목적 관찰비교불동분할방안대인뇌효질류라소서이식류아림상종류적제량효응관계,사선분할조사적우화방안.방법 채용인뇌효질모세포류라소서이식류아림상종류위실험모형진행불동총제량(40、60 Gy)、불동분할방안(200 cGy5차/주、160 cGy2차/d、300 cGy5차/주화400cGy3차/주)급파향약태흔생연합상규분할조사.관찰지표위성류솔、종류복발시간급종류기저최대경,총관찰시간위24주.결과 총제량40 Gy시대분할조근기료효교호(400 cGy3차/주료정결속시성류솔위0),무론채용하충분할방안균미능조단종류지속생장.총제량60 Gy시상규분할적공제효과최차(성류솔위100％),초분할방안적효과상대최호(원기공제위25％),기차위300 cGy5차/주(원기공제위12.5％),400 cGy3차/주상대교차(근기공제교원기호).파향약태흔생연합상규분할60 Gy조사무개선작용.결론 대공제악성뇌효질류아림상종류상규분할모식상불시일개우화방안,초분할160 cGy2차/d화300 cGy5차/주시상대우화방안.
Objective To study dose-response relationship and screen the optimized fractionated irradiation schedules in subclinical tumors of malignant glioma.Methods Balb/c-nude mice bearing human malignant glioma xenograft were assigned randomly into control group,fractionated irradiation schedules group and nimotuzumab-conventional fraction group.The fractionated schedules were 200 cGy x 5f/w,300 cGy ×5f/w,160 cGy ×2f/d x5 d and 400 cGy ×3f/w with total dose of 40 Gy and 60 Gy,respectively.Measurement indexes were tumor-forming rate,average recurrence time and maximum diameter of the tumor bottom.The observation lasted 24 weeks.Results With the total dose of 40 Gy,none of the significant long-term tumor regression were detected in any fractionated irradiation schedules; 400 cGy x 3f/w with complete tumor response at the end of treatment showed a better short-term curative effect.With the total dose of 60 Gy,long-term control rate of each fractionated irradiation schedule group was improved with prolonged average recurrence time of varable degrees,except 200 cGy x 5f/w fractionated schedule (tumor formation rate was 100％ at the end of treatment and average recurrence time was the poorest of 108 d).160 cGy × 2f/d × 5 d fractionated schedule showed the best curative effect with no tumor formation in 2 of 8 mice and longest recurrence time of 143 d.300 cGy x 5f/w fractionated schedule ranked second with no tumor formation in 1 of 8 mice and average recurrence time was 137 d.400 cGy x 3f/w fractionated schedule produced the poorest outcome with no case cured.There were no significant changes in the tumor-forming rate or average recurrence time when nimotuzumab was concurrently used for subclinical tumors of malignant glioma with total dose of 60 Gy.Conclusions Conventional fractionated irradiation is not the best option to control the sustained growth.160 cGy ×2f/d ×5 d and 300 cGy × 5f/w might be the optimized fractionated irradiation schedules for subclinical tumors of malignant glioma.