中华放射肿瘤学杂志
中華放射腫瘤學雜誌
중화방사종류학잡지
CHINESE JOURNAL OF RADIATION ONCOLOGY
2013年
4期
274-277
,共4页
王宁%魏丽春%李围围%胡静%刘隽悦%李剑平%周咏春%张莹%石梅
王寧%魏麗春%李圍圍%鬍靜%劉雋悅%李劍平%週詠春%張瑩%石梅
왕저%위려춘%리위위%호정%류준열%리검평%주영춘%장형%석매
宫颈肿瘤/外科学%宫颈肿瘤/同期放化疗法%预后
宮頸腫瘤/外科學%宮頸腫瘤/同期放化療法%預後
궁경종류/외과학%궁경종류/동기방화요법%예후
Cervical neoplasms/surgery%Cervical neoplasms/concurrent chemoradiotherapy%Prognosis
目的 比较宫颈癌术前同期放化疗加根治术与根治性放疗同期化疗的临床疗效及远期不良反应.方法 回顾分析2004-2011年收治的243例ⅡB期宫颈癌患者,121例术前同期放化疗加根治术(放化疗手术组),122例根治性放疗同期化疗(放化疗组),化疗方案为顺铂40 mg/m2·周.Kaplan-Meier法计算生存率等并Logrank法检验,Cox法多因素预后分析.结果 放化疗手术组、放化疗组随访率均为100%,随访时间满3年样本数分别为34、33例.放化疗手术组与放化疗组3年无进展生存率(PFS)为91.5%与82.0% (P=0.013),总生存率(OS)为95.5%与89.2%(P=0.085),局控率为96.7%与93.4% (P =0.375).肿瘤直径(≥6 cm)、年龄(≤35岁)为放化疗手术组PFS预后因素(P =0.033、0.037).病理类型(非鳞癌)、肿瘤直径(≥6 cm)为放化疗组PFS预后因素(P=0.013、0.002),其中肿瘤直径(≥6 cm)也是OS预后因素(P=0.007).放化疗手术组下肢水肿发生率较高(P =0.000),放化疗组放射性肠炎发生率较高(P =0.000).结论 初步结果表明术前同期放化疗加根治术能获得较好预后,肿瘤直径为两个组共同的PFS预后因素.
目的 比較宮頸癌術前同期放化療加根治術與根治性放療同期化療的臨床療效及遠期不良反應.方法 迴顧分析2004-2011年收治的243例ⅡB期宮頸癌患者,121例術前同期放化療加根治術(放化療手術組),122例根治性放療同期化療(放化療組),化療方案為順鉑40 mg/m2·週.Kaplan-Meier法計算生存率等併Logrank法檢驗,Cox法多因素預後分析.結果 放化療手術組、放化療組隨訪率均為100%,隨訪時間滿3年樣本數分彆為34、33例.放化療手術組與放化療組3年無進展生存率(PFS)為91.5%與82.0% (P=0.013),總生存率(OS)為95.5%與89.2%(P=0.085),跼控率為96.7%與93.4% (P =0.375).腫瘤直徑(≥6 cm)、年齡(≤35歲)為放化療手術組PFS預後因素(P =0.033、0.037).病理類型(非鱗癌)、腫瘤直徑(≥6 cm)為放化療組PFS預後因素(P=0.013、0.002),其中腫瘤直徑(≥6 cm)也是OS預後因素(P=0.007).放化療手術組下肢水腫髮生率較高(P =0.000),放化療組放射性腸炎髮生率較高(P =0.000).結論 初步結果錶明術前同期放化療加根治術能穫得較好預後,腫瘤直徑為兩箇組共同的PFS預後因素.
목적 비교궁경암술전동기방화료가근치술여근치성방료동기화료적림상료효급원기불량반응.방법 회고분석2004-2011년수치적243례ⅡB기궁경암환자,121례술전동기방화료가근치술(방화료수술조),122례근치성방료동기화료(방화료조),화료방안위순박40 mg/m2·주.Kaplan-Meier법계산생존솔등병Logrank법검험,Cox법다인소예후분석.결과 방화료수술조、방화료조수방솔균위100%,수방시간만3년양본수분별위34、33례.방화료수술조여방화료조3년무진전생존솔(PFS)위91.5%여82.0% (P=0.013),총생존솔(OS)위95.5%여89.2%(P=0.085),국공솔위96.7%여93.4% (P =0.375).종류직경(≥6 cm)、년령(≤35세)위방화료수술조PFS예후인소(P =0.033、0.037).병리류형(비린암)、종류직경(≥6 cm)위방화료조PFS예후인소(P=0.013、0.002),기중종류직경(≥6 cm)야시OS예후인소(P=0.007).방화료수술조하지수종발생솔교고(P =0.000),방화료조방사성장염발생솔교고(P =0.000).결론 초보결과표명술전동기방화료가근치술능획득교호예후,종류직경위량개조공동적PFS예후인소.
Objective To compare concurrent radiochemotherapy (CRCT) followed by radical surgery and radical radiotherapy (RT) with concurrent weekly cisplatin in terms of survival rates and longterm toxicities in patients with FIGO stage ⅡB cervical cancer.Methods A retrospective analysis was performed on 243 patients with FIGO stage ⅡB cervical cancer who were admitted to our hospital from November 2004 to November 2011.Of the 243 patients,121 patients received CRCT followed by radical surgery (group 1),and 122 received radical RT with concurrent chemotherapy (weekly cisplatin,40 mg/m2) (group 2).The Kaplan-Meier method was used to calculate survival rates,and the log-rank test was used for survival difference analysis ; the Cox model was used for multivariate prognostic analysis.Results The follow-up rate was 100% in groups 1 and 2.34 and 33 patients were followed up for at least 3 years in groups 1 and 2.The 3-year progression-free survival (PFS) rates,overall survival (OS) rates,and local control rates for groups 1 and 2 were 91.5% vs 82.0% (P =0.013),95.5% vs 89.2% (P =0.085),and 96.7% vs 93.4% (P =0.375),respectively.In group 1,the patients with a tumor diameter of ≥6 cm and an age of ≤35 years had a significantly lower 3-year PFS rate than those with a tumor diameter of < 6 cm and an ageof>35 years (68.2% vs 93.8%,P=0.004;74.1% vs 93.2%,P=0.037).In group 2,the patients with non-squamous cell carcinoma and a tumor diameter of ≥6 cm had a significantly lower 3-year PFS rate than those with squamous cell carcinoma and a tumor diameter of < 6 cm (50.0% vs 83.0%,P =0.013 ;25.0% vs 86.0%,P =0.002).In groups 1 and 2,the patients with a tumor diameter of ≥6 cm had a significantly lower 3-year OS rate than those with a tumor diameter of < 6 cm (78.8% vs 97.0%,P =0.033 ;46.9% vs 92.6%,P =0.007).Leg edema occurred more frequently in group 1 than in group 2 (33.1% vs 8.2%,P=0.000),while radiation enteritis more frequently in group 2 than in group 1 (31.2% vs 5.0%,P =0.000).Conclusions CRCT followed by radical surgery may lead to better PFS than radical RT with weekly cisplatin in patients with FIGO stage ⅡB cervical cancer.Tumor diameter is the common prognostic factor for PFS in patients who receive the two treatments.