CAJ | 학술논문

目的探讨多目标优化(MCO)算法在调强放疗计划优化中的应用.方法随机抽取已接受治疗的10例前列腺癌和10例肺癌患者的调强治疗计划,这些计划都是基于直接子野优化算法进行优化的.在射野方向等设置条件不变前提下,改用MCO算法重新优化治疗计划.比较两种优化算法得到的剂量体积直方图参数、计划优化时间和机器跳数,并行配对t检验.结果两种优化算法得到的调强计划均满足临床要求.与DMPO算法相比,在靶区剂量分布无差别下MCO算法使得前列腺癌计划中的直肠、膀胱及小肠受量均有不同程度降低,计划优化时间减少58％,机器跳数平均增加32％；在肺癌计划中肺、心脏和脊髓受量均有不同程度降低,计划优化时间减少59％,机器跳数平均增加11％.结论与DMPO算法相比,MCO算法可显著降低危及器官受照剂量、缩短计划优化时间.
목적 탐토다목표우화(MCO)산법재조강방료계화우화중적응용.방법 수궤추취이접수치료적10례전렬선암화10례폐암환자적조강치료계화,저사계화도시기우직접자야우화산법진행우화적.재사야방향등설치조건불변전제하,개용MCO산법중신우화치료계화.비교량충우화산법득도적제량체적직방도삼수、계화우화시간화궤기도수,병행배대t검험.결과 량충우화산법득도적조강계화균만족림상요구.여DMPO산법상비,재파구제량분포무차별하MCO산법사득전렬선암계화중적직장、방광급소장수량균유불동정도강저,계화우화시간감소58％,궤기도수평균증가32％；재폐암계화중폐、심장화척수수량균유불동정도강저,계화우화시간감소59％,궤기도수평균증가11％.결론 여DMPO산법상비,MCO산법가현저강저위급기관수조제량、축단계화우화시간.
Objective The aim of this study was to evaluate the role of multicriteria optimization (MCO) in planning of intensity-modulated radiotherapy (IMRT).Methods Twenty IMRT patients (ten with prostate and ten with lung cancers) were randomly selected.For these patients,the treatment plans were designed with direct machine parameter optimization (DMPO).Based on these plans,new plans were designed with MCO,while keeping the setting conditions unchanged.Comparison was made between the two plans including the dose distribution,the dose volume histogram,the time of optimization and number of monitor unit (MU),but were play by pairing-t test.Results The plan designed in both optimizations satisfied all clinical requirements.For the same or better target coverage,rectum,bladder and small bowel were better with MCO compared with DMPO,MCO reduced 58％ of the time for optimization by average while MU increased 32％ by average for prostate cancer.For lung cancer,the whole lung,heart and spinal cord were better with MCO compared with DMPO,MCO reduced 59％ of the time for optimization by average while MU increased 11％ by average.Conclusions In comparison with DMPO,MCO reduces the dose of organs at risk,shorten the time of optimization.