CAJ | 학술논문

目的探讨鼻腔恶性肿瘤乳腺转移的临床表现及预后特征.方法搜集1999年1月至2011年12月本院收治的846鼻腔恶性肿瘤患者临床资料,对发生乳腺转移患者的临床特征性表现、诊断方法、病理特点及预后进行分析.结果共6例女性患者出现乳腺转移,发生率占0.7％.年龄13～37岁,中位数25岁.鼻腔原发灶病理分型分别为横纹肌肉瘤为3例、嗅神经母细胞瘤3例.腺转移多为多灶病变,可伴有其他部位的远处转移.6例患者中5例原发灶接受66～ 72 Gy分30～ 33次根治性放疗,1例鼻腔横纹肌肉瘤患者原发灶放疗14 Gy分7次时乳腺转移先行局部切除后给予原发灶44 Gy姑息放疗.6例患者中5例接受乳腺手术治疗,1例嗅神经母细胞瘤患者因乳腺转移前已发现多发肺转移及骨转移故接受了6周期环磷酰胺+阿霉素+长春新碱化疗.出现乳腺转移后的中位生存期为12.7个月.结论鼻腔肿瘤的年轻女性患者易出现乳腺转移,超声检查可以为乳腺转移的诊断提供有用的信息,鼻腔肿瘤患者一旦出现乳腺及其他部位远处转移预后差.
목적 탐토비강악성종류유선전이적림상표현급예후특정.방법 수집1999년1월지2011년12월본원수치적846비강악성종류환자림상자료,대발생유선전이환자적림상특정성표현、진단방법、병리특점급예후진행분석.결과 공6례녀성환자출현유선전이,발생솔점0.7％.년령13～37세,중위수25세.비강원발조병리분형분별위횡문기육류위3례、후신경모세포류3례.선전이다위다조병변,가반유기타부위적원처전이.6례환자중5례원발조접수66～ 72 Gy분30～ 33차근치성방료,1례비강횡문기육류환자원발조방료14 Gy분7차시유선전이선행국부절제후급여원발조44 Gy고식방료.6례환자중5례접수유선수술치료,1례후신경모세포류환자인유선전이전이발현다발폐전이급골전이고접수료6주기배린선알+아매소+장춘신감화료.출현유선전이후적중위생존기위12.7개월.결론 비강종류적년경녀성환자역출현유선전이,초성검사가이위유선전이적진단제공유용적신식,비강종류환자일단출현유선급기타부위원처전이예후차.
Objective To detect the clinical features and prognostic factors of nasal cavity malignancy with breast metastasis.Methods 846 Patients with nasal cavity malignancy from January 1999 to December 2011 were enrolled,the clinical and pathological features,clinical diagnostic methods and prognostic factors for breast metastasis patients were analyzed.Results Six female cases (median age 25) were diagnosed with breast metastasis,including 3 rhabdomyosarcoma and 3 olfactory neuroblastoma; consisting 0.7％ of the total 846 cases of primary nasal malignancy group.The metastasis were more likely to be multiple breast lesions with/without metastasis in other site.For the primary tumor,five patients received 66-72 Gy/30-33f of radical radiotherapy,one patient with rest rhabdomyosarcoma received 58 Gy of palliative radiation since breast metastasis was found after 14 Gy of radiation and breast mass resection were performed right after.For the breast metastasis,five of 6 patients received breast surgery,one patients with olfactory neuroblastoma received 6 cycles cyclophosphamide + adriamycin + vincristine chemotherapy.Median survival was 12.7 months.Conclusions For nasal cavity malignancy,breast metastasis more likely occur in younger female patients.Ultrasound may provide useful information in evaluating breast metastasis.Cases combined with metastasis except breast have unfavorable prognosis.