CAJ | 학술논문

目的探讨P-选择素(P-selectin,P-sel)、血栓前体蛋白(thrombus precursor protein,TpP)、D-二聚体(D-dimer,D-D)对门静脉高压症患者行脾脏切除(或联合血管断流)术后门静脉血栓形成(portal vein thrombosis,PVT)的早期预测价值.方法 2009-2011年入我院的48例行脾脏切除术的门静脉高压症患者根据血栓发生情况分为血栓组(26例)和非血栓组(22例).动态监测两组患者术前1d以及术后第1、3、5、7、14天P-sel、TpP及D-D含量,并进行统计学分析.结果术前血栓组和非血栓组三项指标水平并无显著性差异(P＞0.05).术后第1天血栓组三项指标较非血栓组明显升高(P＜0.05).其中P-sel的受试者操作特征曲线下面积(area under curve,AUC)最大(0.893),其次为D-D、TpP;三者联合检测,其AUC高达0.977.结论 P-sel、TpP、D-D三者联合检测有助于PVT的早期预测.
목적 탐토P-선택소(P-selectin,P-sel)、혈전전체단백(thrombus precursor protein,TpP)、D-이취체(D-dimer,D-D)대문정맥고압증환자행비장절제(혹연합혈관단류)술후문정맥혈전형성(portal vein thrombosis,PVT)적조기예측개치.방법 2009-2011년입아원적48례행비장절제술적문정맥고압증환자근거혈전발생정황분위혈전조(26례)화비혈전조(22례).동태감측량조환자술전1d이급술후제1、3、5、7、14천P-sel、TpP급D-D함량,병진행통계학분석.결과 술전혈전조화비혈전조삼항지표수평병무현저성차이(P＞0.05).술후제1천혈전조삼항지표교비혈전조명현승고(P＜0.05).기중P-sel적수시자조작특정곡선하면적(area under curve,AUC)최대(0.893),기차위D-D、TpP;삼자연합검측,기AUC고체0.977.결론 P-sel、TpP、D-D삼자연합검측유조우PVT적조기예측.
Objective To investigate the predictive values of P-selectin (P-sel),thrombus precursor protein (TpP) and D-dimer (D-D) in the early diagnosis of portal vein thrombosis (PVT) in patients submitted to splenectomy (or to devascularization).Methods The clinical data of 48 patients with portal hypertension (the PVT group,n=26; and the non-PVT group,n=22) who received operation in our hospital from 2009 to 2011 were retrospectively analyzed.Detecting the P-sel,TpP and D-D levels in the two groups of patients were done on preoperative day 1 and postoperative day 1,3,5,7,14.The SPSS software was used for statistic analysis.Results There were no significant differences on the preoperative day 1 levels of P-sel,TpP and D-D in the two groups (P＞0.05).The postoperative day1 levels of the three indicators in the PVT group were significantly higher than the non-PVT group (P＜0.05).Receiver operating characteristic (ROC) curves showed the area under curve (AUC) of P-sel was largest (0.893),followed by D-D,and TpP.The combined detection of the 3 indicators was highest,with the AUC up to 0.977.Conclusions Combined detection of P-sel,D-D and TpP levels were useful in the early diagnosis of PVT after splenectomy in patients with portal hypertension.