CAJ | 학술논문

肝癌的发生发展与癌基因的过表达或者抑癌基因的低表达密切相关.Sirtuin家族是一类依赖NAD+的组蛋白去乙酰化酶.它们通过与多种组蛋白及非组蛋白相互作用,在代谢调节、抗衰老、炎症反应以及肿瘤发生发展等过程发挥着重要作用.近来越来越多的证据显示SIRT1能够使抑癌基因去乙酰化从而促进肝癌的发生.然而,另一方面,SIRT1也能够降低代谢相关的肝癌小鼠成瘤率.本文就sirtuin家族成员在肝细胞癌发生发展中的表达及临床意义作一综述.
간암적발생발전여암기인적과표체혹자억암기인적저표체밀절상관.Sirtuin가족시일류의뢰NAD+적조단백거을선화매.타문통과여다충조단백급비조단백상호작용,재대사조절、항쇠로、염증반응이급종류발생발전등과정발휘착중요작용.근래월래월다적증거현시SIRT1능구사억암기인거을선화종이촉진간암적발생.연이,령일방면,SIRT1야능구강저대사상관적간암소서성류솔.본문취sirtuin가족성원재간세포암발생발전중적표체급림상의의작일종술.
Hepatocellular carcinoma (HCC) development is closely related to overexpression of tumor promoters or down-regulation of tumor suppressors.The mammalian sirtuin family was found to be a nicotinamide adenosine dinucleotide (NAD/NADH)-dependent histone deacetylase (HDAC),which implicated in the regulation of critical biological processes through deacetylation modifying on histone and nonhistone.SIRT1 can regulate metabolism,aging,inflammation and cancer progression.In particular,more and more evidence proves that SIRT1 can act as a tumor promot er in hepatocellular carcinoma through deacetylation on tumor suppressors.On the other hand,SIRT1 can strongly suppress metabolic syndrome-associated liver cancer in the mouse model.This review will discuss the expression of sirtuin family member in liver cancer and its clinical significance.