中华肝胆外科杂志
中華肝膽外科雜誌
중화간담외과잡지
CHINESE JOURNAL OF HEPATOBILIARY SURGERY
2014年
4期
290-293
,共4页
肝细胞癌%TFIIB相关因子2%微血管密度%复发%预后
肝細胞癌%TFIIB相關因子2%微血管密度%複髮%預後
간세포암%TFIIB상관인자2%미혈관밀도%복발%예후
Hepatocellular carcinoma%TFIIB-related factor 2%Microvessel density%Recurrence%Prognosis
目的 探讨TFIIB相关因子2(BRF2)蛋白在肝细胞癌(HCC)中的表达及其临床意义.方法 收集2009年11月至2010年1 1月在山东大学齐鲁医院普通外科行根治性肝切除手术治疗的80例HCC患者资料.应用免疫组织化学方法检测HCC癌组织、癌旁组织和正常肝组织中BRF2、CD34(微血管密度)的表达情况.运用统计学方法分析BRF2、CD34表达与临床病理指标的关系.结果 HCC患者癌组织BRF2的高表达率为61.3％,高于正常肝组织及癌旁组织(阳性率分别为31.6％、28.8％,P＜0.05).BRF2与肿瘤分化、结节数目、包膜有无、TNM分期及微血管密度相关.BRF2高表达组预后差:高表达组复发转移率明显高于低表达组(P＜0.05),同时生存率低于低表达组(P＜0.05).结论 BRF2蛋白在HCC患者癌组织表达水平升高,与患者病理指标及预后相关,因此推测BRF2或可用作评价HCC患者预后的指标.
目的 探討TFIIB相關因子2(BRF2)蛋白在肝細胞癌(HCC)中的錶達及其臨床意義.方法 收集2009年11月至2010年1 1月在山東大學齊魯醫院普通外科行根治性肝切除手術治療的80例HCC患者資料.應用免疫組織化學方法檢測HCC癌組織、癌徬組織和正常肝組織中BRF2、CD34(微血管密度)的錶達情況.運用統計學方法分析BRF2、CD34錶達與臨床病理指標的關繫.結果 HCC患者癌組織BRF2的高錶達率為61.3％,高于正常肝組織及癌徬組織(暘性率分彆為31.6％、28.8％,P＜0.05).BRF2與腫瘤分化、結節數目、包膜有無、TNM分期及微血管密度相關.BRF2高錶達組預後差:高錶達組複髮轉移率明顯高于低錶達組(P＜0.05),同時生存率低于低錶達組(P＜0.05).結論 BRF2蛋白在HCC患者癌組織錶達水平升高,與患者病理指標及預後相關,因此推測BRF2或可用作評價HCC患者預後的指標.
목적 탐토TFIIB상관인자2(BRF2)단백재간세포암(HCC)중적표체급기림상의의.방법 수집2009년11월지2010년1 1월재산동대학제로의원보통외과행근치성간절제수술치료적80례HCC환자자료.응용면역조직화학방법검측HCC암조직、암방조직화정상간조직중BRF2、CD34(미혈관밀도)적표체정황.운용통계학방법분석BRF2、CD34표체여림상병리지표적관계.결과 HCC환자암조직BRF2적고표체솔위61.3％,고우정상간조직급암방조직(양성솔분별위31.6％、28.8％,P＜0.05).BRF2여종류분화、결절수목、포막유무、TNM분기급미혈관밀도상관.BRF2고표체조예후차:고표체조복발전이솔명현고우저표체조(P＜0.05),동시생존솔저우저표체조(P＜0.05).결론 BRF2단백재HCC환자암조직표체수평승고,여환자병리지표급예후상관,인차추측BRF2혹가용작평개HCC환자예후적지표.
Objective To study the expression of TFIIB-related factor 2 (BRF2) in hepatocellular carcinoma(HCC) and to determine its clinical significance.Methods 80 HCC patients who received ‘curative' hepatectomy at the Qilu Hospital were studied.Immunohistochemistry analysis was performed to examine the expression of BRF2 and CD34 (microvessel density) in tumor tissues,matched paraneoplastic tissues,and normal liver tissues.Statistical methods were performed to analyse the relationships of expressions of BRF2 and CD34 with clinicopathologic factors.Results BRF2 protein was expressed at a high rate of 61.3％ in HCC tumor,which was significantly higher than that in normal liver tissues and matched paraneoplastic tissues (31.6％,28.8 ％,respectively,P ＜ 0.05).BRF2 was significantly associated with tumor differentiation,number of nodules,tumor encapsulation,TNM stage,and microvessel density.Prognosis of the high expression BRF2 group was poor.The recurrence and metastasis rates in the high expression group were significantly higher than the low expression group (P ＜ 0.05).The survival rate in the high expression group was significantly lower than the low expression group (P ＜ 0.05).Conclusions The expression of BRF2 increased in HCC tissues,and its expression was closely associated with pathological features and prognosis of patients,indicating that it can be used as a predictor in assessing prognosis of patients with HCC.
