CAJ | 학술논문

肝内胆管细胞癌(ICC)是除肝细胞癌(HCC)外发生率最高的肝脏恶性肿瘤.流行病学研究发现,ICC的发生及发展与HBV感染相关.本文通过回顾近几年来的相关文献,主要对HBV感染所致ICC可能的发生机制进行了初步总结.HBV相关ICC可能的形成机制有:(1)HBV感染肝干/祖细胞间接造成肝内胆管上皮细胞感染HBV而致癌变;(2) HBV感染致肝内胆管上皮细胞所处微环境改变而致癌变;(3)HBV感染致肝干/祖细胞癌变形成肿瘤样干细胞并分化成肝内胆管上皮细胞样癌细胞.
간내담관세포암(ICC)시제간세포암(HCC)외발생솔최고적간장악성종류.류행병학연구발현,ICC적발생급발전여HBV감염상관.본문통과회고근궤년래적상관문헌,주요대HBV감염소치ICC가능적발생궤제진행료초보총결.HBV상관ICC가능적형성궤제유:(1)HBV감염간간/조세포간접조성간내담관상피세포감염HBV이치암변;(2) HBV감염치간내담관상피세포소처미배경개변이치암변;(3)HBV감염치간간/조세포암변형성종류양간세포병분화성간내담관상피세포양암세포.
Intrahepatic cholangiocarcinoma is the second most common intrahepatic primary liver tumor after hepatocellular carcinoma (HCC).Epidemiological study suggests a strong correlation between HBV infection and ICC development.This review focused on the potential mechanisms of HBV-induced ICC and gives a primary summary of suggested hypothesis,which included:(1) HBV infection of liver stem/progenitor cells will indirectly lead to HBV infection of intrahepatic biliary epithelial cells and lead to the development of ICC; (2) the changed microenvironment of intrahepatic biliary epithelial cells by HBV infection eventually results in carcinogenesis ; (3) the HBV infection of hepatic sten/progenitor cell can transform into tumor-like stem cells and ultimately differentiate into ICC-like tumor cells.