CAJ | 학술논문

目的研究布加综合征(BCS)患者血清糖类抗原-125(CA-125)的表达水平及其意义.方法选取2011年8月至2013年4月初次确诊的235例BCS患者作为研究组,随机选取120例健康志愿者作为对照组,检测分析两组血清CA-125水平.结果研究组血清CA-125水平高于对照组[(147.9 ±246.6)kU/L比(16.0±7.2)kU/L,P＜0.001].研究组血清CA-125水平与腹水量、天冬氨酸氨基转移酶、丙氨酸氨基转移酶、白蛋白、Rotterdam BCS预后评级显著相关(P ＜0.001),相关系数分别为0.79、0.45、0.29、-0.393、0.71.截止2013年10月,血清CA-125高于正常值上限5倍(＞175kU/L)的BCS患者(68例)介入治疗后生存率和无症状生存率(分别为95.6％和79.8％)均低于其余BCS患者(167例,分别为98.8％和92.0％,P＜0.05).结论 BCS患者血清CA-125水平高于正常人群,与腹水量、肝脏损伤程度以及Rotterdam BCS预后评级均呈正相关.BCS患者血清CA-125异常升高提示预后相对较差.
목적 연구포가종합정(BCS)환자혈청당류항원-125(CA-125)적표체수평급기의의.방법 선취2011년8월지2013년4월초차학진적235례BCS환자작위연구조,수궤선취120례건강지원자작위대조조,검측분석량조혈청CA-125수평.결과 연구조혈청CA-125수평고우대조조[(147.9 ±246.6)kU/L비(16.0±7.2)kU/L,P＜0.001].연구조혈청CA-125수평여복수량、천동안산안기전이매、병안산안기전이매、백단백、Rotterdam BCS예후평급현저상관(P ＜0.001),상관계수분별위0.79、0.45、0.29、-0.393、0.71.절지2013년10월,혈청CA-125고우정상치상한5배(＞175kU/L)적BCS환자(68례)개입치료후생존솔화무증상생존솔(분별위95.6％화79.8％)균저우기여BCS환자(167례,분별위98.8％화92.0％,P＜0.05).결론 BCS환자혈청CA-125수평고우정상인군,여복수량、간장손상정도이급Rotterdam BCS예후평급균정정상관.BCS환자혈청CA-125이상승고제시예후상대교차.
Objective To investigated the serum level of carcinoma antigen 125 (CA-125) and its clinical significance in patients with Budd-Chiari syndrome.Methods We reviewed medical records and laboratory tests of patients with BCS first diagnosed in our hospital between August 2011 and April 2013.235 patients were included as experiment group,while 120 healthy adult volunteers were randomly selected as control group.The serum level of CA-125 were detected by electrochemilumescence immunization assay in this single-center retrospective control study.Results The average serum level of CA-125 in experiment group is higher than that of control group [(147.9 ±246.6) kU/L vs (16.0 ±7.2) kU/L,P ＜0.001].In experiment group,the relative coefficient for serum CA-125 with ascites,alanine aminotransferase,aspartate aminotransferase,albumin and Rotterdam BCS scores was 0.79,0.45,0.29,-0.393 and 0.71,respec tively,P ＜0.001.As of October 2013,we found that the 68 BCS patients with serum CA-125 level 5-fold higher than the upper limit of normal (＞ 175 kU/L) presented much lower survival rates and asymptomatic survival rates than the rest 167 BCS patients after intervention therapy:(95.6％ and 79.8％) vs (98.8％ and 92.0％),P ＜ 0.05.Conclusions The serum level of CA-125 in BCS patients have positive correlation with ascites volume,liver injury degree and Rotterdam BCS scores.Serum CA-125 evaluation appears to be a valuable examination option in BCS as CA-125 levels negatively correlate with worse prognosis,thus could be applied as an efficient tool for prognostication.