中华肝胆外科杂志
中華肝膽外科雜誌
중화간담외과잡지
CHINESE JOURNAL OF HEPATOBILIARY SURGERY
2014年
10期
697-699
,共3页
刘扬%王跃如%王龙%周波%宋振顺%Butterfield Lisa H.%张柏和%吴孟超
劉颺%王躍如%王龍%週波%宋振順%Butterfield Lisa H.%張柏和%吳孟超
류양%왕약여%왕룡%주파%송진순%Butterfield Lisa H.%장백화%오맹초
肝细胞癌%甲胎蛋白信使核糖核酸(AFPmRNA)
肝細胞癌%甲胎蛋白信使覈糖覈痠(AFPmRNA)
간세포암%갑태단백신사핵당핵산(AFPmRNA)
Hepatocellular carcinoma%Alpha-fetoprotein messenger RNA (AFPmRNA)
目的 探讨血液肝癌细胞相关甲胎蛋白(AFP) mRNA阳性与肝癌患者术后肿瘤复发或转移的关系.方法 应用巢式RT-PCR检测62例原发性肝癌患者术前1天周围静脉血液中AFPmRNA,术后随访3年.结果 24例术前血液检测AFPmRNA阳性,38例患者术前AFPmRNA呈阴性.术前血AFPmRNA阳性的患者术后1、2、3年肿瘤复发率分别为58.3％ (14/24)、75.0％(18/24)、100.0％ (24/24);而术前血AFPmRNA阴性的患者术后1、2、3年肿瘤复发率则分别为23.6％ (10/38)、42.1％(16/38)、68.4％(26/38),两者比较复发率差异具有统计学意义(P＜0.01).术前血AFPmRNA阳性的患者术后3年有8.3％ (2/24)发生肺转移;而阴性患者术后3年内无一发生肺或其他远处转移(0.0％,0/38;P＜0.01).结论 术前血液AFPmRNA阳性的肝癌患者较AFPmRNA阴性的肝癌患者术后更容易产生复发或远处转移.
目的 探討血液肝癌細胞相關甲胎蛋白(AFP) mRNA暘性與肝癌患者術後腫瘤複髮或轉移的關繫.方法 應用巢式RT-PCR檢測62例原髮性肝癌患者術前1天週圍靜脈血液中AFPmRNA,術後隨訪3年.結果 24例術前血液檢測AFPmRNA暘性,38例患者術前AFPmRNA呈陰性.術前血AFPmRNA暘性的患者術後1、2、3年腫瘤複髮率分彆為58.3％ (14/24)、75.0％(18/24)、100.0％ (24/24);而術前血AFPmRNA陰性的患者術後1、2、3年腫瘤複髮率則分彆為23.6％ (10/38)、42.1％(16/38)、68.4％(26/38),兩者比較複髮率差異具有統計學意義(P＜0.01).術前血AFPmRNA暘性的患者術後3年有8.3％ (2/24)髮生肺轉移;而陰性患者術後3年內無一髮生肺或其他遠處轉移(0.0％,0/38;P＜0.01).結論 術前血液AFPmRNA暘性的肝癌患者較AFPmRNA陰性的肝癌患者術後更容易產生複髮或遠處轉移.
목적 탐토혈액간암세포상관갑태단백(AFP) mRNA양성여간암환자술후종류복발혹전이적관계.방법 응용소식RT-PCR검측62례원발성간암환자술전1천주위정맥혈액중AFPmRNA,술후수방3년.결과 24례술전혈액검측AFPmRNA양성,38례환자술전AFPmRNA정음성.술전혈AFPmRNA양성적환자술후1、2、3년종류복발솔분별위58.3％ (14/24)、75.0％(18/24)、100.0％ (24/24);이술전혈AFPmRNA음성적환자술후1、2、3년종류복발솔칙분별위23.6％ (10/38)、42.1％(16/38)、68.4％(26/38),량자비교복발솔차이구유통계학의의(P＜0.01).술전혈AFPmRNA양성적환자술후3년유8.3％ (2/24)발생폐전이;이음성환자술후3년내무일발생폐혹기타원처전이(0.0％,0/38;P＜0.01).결론 술전혈액AFPmRNA양성적간암환자교AFPmRNA음성적간암환자술후경용역산생복발혹원처전이.
Objective To study the correlation between positive peripheral blood hepatocellular carcinoma (HCC) cells-associated AFPmRNA and HCC recurrence / distant metastasis after HCC resection.Methods We studied blood AFPmRNA in 62 HCC patients using nested RT-PCR 1 day before hepatectomy,and followed these patients up for 1 to 3 years after surgery.Results 24 HCC patients were tested AFPmRNA positive before surgery,while 38 HCC patients were tested negative.Of the 24 patients who were tested positive for AFPmRNA,14 relapsed (14/24,58.3％) within the first year of surgery,4 in the second year (18/24,75.0％),the remaining 6 in the third year (24/24,100％).For the 38 patients who were tested AFPmRNA negative,10 patients (10/38,26.3％) relapsed within the first year,6 in the second year (16/38,42.1％),and 10 in the third year (26/38,68.4％,P ＜ 0.01).There was significant difference between patients who were tested AFPmRNA positive and AFPmRNA negative in relation to tumor recurrence (P ＜ 0.01).Among 24 patients who were tested AFPmRNA positive,2 patients developed lung metastasis in the third year (2/24,8.3％).There was no patient who developed lung metastasis or distal metastasis in the third year in the patients who were tested AFPmRNA negative (0/38,0.0％,P ＜ 0.01).Conclutions HCC patients who were tested AFPmRNA positive before operation were more prone to develop HCC recurrence or distal metastasis when compared with those patients who were tested AFPmRNA negative.
