中华肝脏病杂志
中華肝髒病雜誌
중화간장병잡지
CHINESE JOURNAL OF HEPATOLOGY
2013年
12期
929-933
,共5页
Gilbert综合征%超微结构%胆色素类%肝炎,乙型,慢性
Gilbert綜閤徵%超微結構%膽色素類%肝炎,乙型,慢性
Gilbert종합정%초미결구%담색소류%간염,을형,만성
Gilbert's syndrome%Ultrastructure%Bile pigments%Hepatitis B,chronic
目的 研究先天性高胆红素血症Gilbert综合征患者的肝脏病理特点. 方法 Gilbert综合征患者通过基因突变检测而确诊.然后用透射电子显微镜分别对7例Gilbert综合征(GS组)和8例慢性乙型肝炎患者(CHB组)的肝脏结构进行组织学、超微结构观察,重点观察肝小叶结构变化以及肝细胞内色素颗粒特征. 结果 GS组患者的肝脏肝小叶结构正常,汇管区与小叶内无病变;肝细胞内见大量的高电子密度颗粒.CHB组患者的肝脏汇管区胆管上皮破坏,炎性细胞浸润,肝小叶有破坏,肝细胞内偶有胆色素颗粒. 结论 Gilbert综合征患者的肝脏结构基本正常,不影响预后,肝细胞内大量色素沉积为其特点.
目的 研究先天性高膽紅素血癥Gilbert綜閤徵患者的肝髒病理特點. 方法 Gilbert綜閤徵患者通過基因突變檢測而確診.然後用透射電子顯微鏡分彆對7例Gilbert綜閤徵(GS組)和8例慢性乙型肝炎患者(CHB組)的肝髒結構進行組織學、超微結構觀察,重點觀察肝小葉結構變化以及肝細胞內色素顆粒特徵. 結果 GS組患者的肝髒肝小葉結構正常,彙管區與小葉內無病變;肝細胞內見大量的高電子密度顆粒.CHB組患者的肝髒彙管區膽管上皮破壞,炎性細胞浸潤,肝小葉有破壞,肝細胞內偶有膽色素顆粒. 結論 Gilbert綜閤徵患者的肝髒結構基本正常,不影響預後,肝細胞內大量色素沉積為其特點.
목적 연구선천성고담홍소혈증Gilbert종합정환자적간장병리특점. 방법 Gilbert종합정환자통과기인돌변검측이학진.연후용투사전자현미경분별대7례Gilbert종합정(GS조)화8례만성을형간염환자(CHB조)적간장결구진행조직학、초미결구관찰,중점관찰간소협결구변화이급간세포내색소과립특정. 결과 GS조환자적간장간소협결구정상,회관구여소협내무병변;간세포내견대량적고전자밀도과립.CHB조환자적간장회관구담관상피파배,염성세포침윤,간소협유파배,간세포내우유담색소과립. 결론 Gilbert종합정환자적간장결구기본정상,불영향예후,간세포내대량색소침적위기특점.
Objective To explore the pathological characteristics of inborn hyperbilirubinemia of patients with Gilbert's syndrome (GS).Methods Patients with GS (n =7) and patients with chronic hepatitis B (CHB; n =8) were enrolled in the study.GS was diagnosed by peripheral blood analysis results showing glucuronyl transferase gene mutation.The histology and ultrastructure of biopsied liver tissues were evaluated by light microscopy and transmission electron microscopy.Results The GS group showed nonnal structure in the hepatic portal area and lobule; however,bile pigment granules with high electron density were noted in the hepatocytes.The CHB group showed abnormal structure of the hepatic lobules,including infiltration of inflammatory cells,necrotic regions,degenerated hepatocytes,bile duct injury,and fibrosis in the portal tracts; a few bile pigment granules were observed.The GS group also showed greater quantity and size of bilirubin deposits than the CHB group.Conclusion The histological and ultrastructural features of GS include normal hepatic lobule and deposition of bile pigment granules in hepatocytes.
