中华肝脏病杂志
中華肝髒病雜誌
중화간장병잡지
CHINESE JOURNAL OF HEPATOLOGY
2014年
1期
53-57
,共5页
刘鹏举%马方%楼慧萍%朱燕宁%陈雨
劉鵬舉%馬方%樓慧萍%硃燕寧%陳雨
류붕거%마방%루혜평%주연저%진우
脂肪肝%尿酸%绝经后期%危险因素
脂肪肝%尿痠%絕經後期%危險因素
지방간%뇨산%절경후기%위험인소
Fatty liver%Uric acid%Postmenopause%Risk factors
目的 分析绝经后女性正常血尿酸(SUA)水平与非酒精性脂肪肝性肝病(NAFLD)的相关性,探讨NAFLD可能的危险因素. 方法 回顾性调查2009年3月至2010年2月在本院接受年度健康体检,且SUA在正常范围的1425名绝经后女性.入选者均测量人体学指标,检测代谢指标及血清生物化学指标；B超检测诊断NAFLD,并根据诊断结果分为NAFLD组和非NAFLD组.以SUA四分位数水平将所有入选者分为Q1组(＜226.1 μ mol/L)、Q2组(226.1 ～＜267.8μmol/L)、Q3组(267.8 ～＜303.5 μmol/L)和Q4组(303.5～≤357.0μmol/L).符合正态分布的计量数据组间比较用独立样本t检验,不符合正态分布的用Mann-Whitney U检验；计数资料的趋势性检验采用R×C表x2检验；危险因素用Binary logistic回归分析并校正混杂因素;不同NAFLD严重程度间的SUA水平比较采用多个独立样本非参数检验(Kruskai-Wallis Test). 结果 本研究人群中的NAFLD患病率为32.8％ (468/1425).Q1、Q2、Q3、Q4组NAFLD患者所占百分比分别为20.4％ (70/343)、26.3％ (104/395)、35.2％ (128/364)、51.4％ (166/323),NAFLD患病率随SUA水平升高呈上升趋势(x2=76.470,P＜0.01).未校正和校正混杂因素的情况下,Q3组和Q4组的NAFLD患病风险均高于Q1组(P值均＜0.01).轻、中、重度NAFLD患者的SUA水平分别为(286.8±48.2)μmol/L、(277.9±53.0) μmol/L、(281.4±48.2) μmol/L,差异无统计学意义(x2=3.025,P＞0.05). 结论 绝经后女性SUA水平与NAFLD独立相关,在正常值范围内的SUA水平升高可能是NAFLD的独立危险因素.
目的 分析絕經後女性正常血尿痠(SUA)水平與非酒精性脂肪肝性肝病(NAFLD)的相關性,探討NAFLD可能的危險因素. 方法 迴顧性調查2009年3月至2010年2月在本院接受年度健康體檢,且SUA在正常範圍的1425名絕經後女性.入選者均測量人體學指標,檢測代謝指標及血清生物化學指標；B超檢測診斷NAFLD,併根據診斷結果分為NAFLD組和非NAFLD組.以SUA四分位數水平將所有入選者分為Q1組(＜226.1 μ mol/L)、Q2組(226.1 ～＜267.8μmol/L)、Q3組(267.8 ～＜303.5 μmol/L)和Q4組(303.5～≤357.0μmol/L).符閤正態分佈的計量數據組間比較用獨立樣本t檢驗,不符閤正態分佈的用Mann-Whitney U檢驗；計數資料的趨勢性檢驗採用R×C錶x2檢驗；危險因素用Binary logistic迴歸分析併校正混雜因素;不同NAFLD嚴重程度間的SUA水平比較採用多箇獨立樣本非參數檢驗(Kruskai-Wallis Test). 結果 本研究人群中的NAFLD患病率為32.8％ (468/1425).Q1、Q2、Q3、Q4組NAFLD患者所佔百分比分彆為20.4％ (70/343)、26.3％ (104/395)、35.2％ (128/364)、51.4％ (166/323),NAFLD患病率隨SUA水平升高呈上升趨勢(x2=76.470,P＜0.01).未校正和校正混雜因素的情況下,Q3組和Q4組的NAFLD患病風險均高于Q1組(P值均＜0.01).輕、中、重度NAFLD患者的SUA水平分彆為(286.8±48.2)μmol/L、(277.9±53.0) μmol/L、(281.4±48.2) μmol/L,差異無統計學意義(x2=3.025,P＞0.05). 結論 絕經後女性SUA水平與NAFLD獨立相關,在正常值範圍內的SUA水平升高可能是NAFLD的獨立危險因素.
목적 분석절경후녀성정상혈뇨산(SUA)수평여비주정성지방간성간병(NAFLD)적상관성,탐토NAFLD가능적위험인소. 방법 회고성조사2009년3월지2010년2월재본원접수년도건강체검,차SUA재정상범위적1425명절경후녀성.입선자균측량인체학지표,검측대사지표급혈청생물화학지표；B초검측진단NAFLD,병근거진단결과분위NAFLD조화비NAFLD조.이SUA사분위수수평장소유입선자분위Q1조(＜226.1 μ mol/L)、Q2조(226.1 ～＜267.8μmol/L)、Q3조(267.8 ～＜303.5 μmol/L)화Q4조(303.5～≤357.0μmol/L).부합정태분포적계량수거조간비교용독립양본t검험,불부합정태분포적용Mann-Whitney U검험；계수자료적추세성검험채용R×C표x2검험；위험인소용Binary logistic회귀분석병교정혼잡인소;불동NAFLD엄중정도간적SUA수평비교채용다개독립양본비삼수검험(Kruskai-Wallis Test). 결과 본연구인군중적NAFLD환병솔위32.8％ (468/1425).Q1、Q2、Q3、Q4조NAFLD환자소점백분비분별위20.4％ (70/343)、26.3％ (104/395)、35.2％ (128/364)、51.4％ (166/323),NAFLD환병솔수SUA수평승고정상승추세(x2=76.470,P＜0.01).미교정화교정혼잡인소적정황하,Q3조화Q4조적NAFLD환병풍험균고우Q1조(P치균＜0.01).경、중、중도NAFLD환자적SUA수평분별위(286.8±48.2)μmol/L、(277.9±53.0) μmol/L、(281.4±48.2) μmol/L,차이무통계학의의(x2=3.025,P＞0.05). 결론 절경후녀성SUA수평여NAFLD독립상관,재정상치범위내적SUA수평승고가능시NAFLD적독립위험인소.
Objective To analyze the relationship between normal serum uric acid (SUA) levels and nonalcoholic fatty liver disease (NAFLD) among postmenopausal women,and determine the possible risk factors of NAFLD in this patient population.Methods Chinese postmenopausal women who participated in the annual health check-up program from March 2009 to February 2010 were retrospectively assessed to identify individuals with SUA within normal range for study inclusion.For the total 1425 study participants,the recorded data of anthropometric parameters,metabolic factors,and serum biochemical parameters were collected.Results from abdominal ultrasonography examination were used to group participants according to presence of fatty liver.Women with fatty liver were divided into NAFLD and non-NAFLD groups.Further sub-grouping was performed according to SUA quartiles,as follows:Q1 group:＜ 226.1 μmol/L); Q2 group:226.1 μmol/L ≤ SUA＜ 267.8 μ mol/L; Q3 group:267.8 μmol/L ≤ SUA＜ 303.5 μmol/L); Q4 group:303.5 μmol/L ≤ SUA ≤ 357.0 μmol/L.The independent-sample t-test was used to compare normally distributed variables between groups,and the Mann-Whitney U test was used to analyze variables with skewed distribution.Categorical variables were examined by the R × Cx2 test.Binary logistic analysis was used to determine the risk factors for fatty liver and to adjust for possible confounders.The multiple non-parameter independent-sample test (Kruskal-Wallis test) was used to compare the differences of SUA levels among NAFLD groups with different disease severity.Results The prevalence of NAFLD among Chinese postmenopausal women with normal SUA was 32.8％,with NAFLD prevalences of 20.4％ (70/343) in women with Q1 SUA,26.3％ (104/395) with Q2 SUA,35.2％ (128/364) with Q3 SUA,and 51.4％ (166/323) with Q4 SUA.The prevalence of fatty liver showed a significant increasing trend according to the SUA quartile (x2 =76.470,P-trend ＜ 0.01).Women in the SUA Q3 and Q4 groups had significantly higher risk of fatty liver presence than women in the Q1 group (P ＜ 0.01 for both,with or without adjustment of confounders).Disease severity did not appear to be related to disease severity,as the SUA levels in women with mild,moderate or severe fatty liver were not significantly different (286.8 ± 48.2 μmol/L vs.277.9 ± 53.0 μmol/L vs.281.4 ± 48.2 μmol/L,respectively; x2 =3.025,P ＞ 0.05).Conclusion SUA levels were independently correlated with NAFLD in Chinese postmenopausal women.SUA levels in the higher quartiles of the normal range may be an independent risk factor of NAFLD.
