CAJ | 학술논문

目的观察高压氧联合静脉滴注前列地尔治疗糖尿病足的临床疗效.方法经患者知情同意后,将90例糖尿病足患者采用数字表法随机分为研究组、高压氧组和前列地尔组,每组30例.3组均予以糖尿病饮食、降血糖药物、营养神经、局部创面处理等常规治疗.研究组在此基础上,应用前列地尔20 μg加入生理盐水100 ml静脉滴注,1次/d,同时采用多人高压氧舱治疗,压力为0.20 MPa,1次/d,10次为1个疗程；高压氧组在常规治疗的基础上,采用高压氧治疗,治疗方法同研究组；前列地尔组在常规治疗的基础上使用前列地尔20μg加入生理盐水100 ml静脉滴注,1次/d.治疗4个疗程后进行临床疗效评定.结果研究组、高压氧组和前列地尔组总有效率分别为93.3％ (28/30)、76.7％(23/30)、70.0％(21/30),前者与后两者比较差异均有统计学意义(P＜0.05).结论高压氧联合前列地尔治疗糖尿病足有利于下肢动脉血供、氧供,改善微循环,提高溃疡愈合率,是治疗糖尿病足的有效方案.
목적 관찰고압양연합정맥적주전렬지이치료당뇨병족적림상료효.방법 경환자지정동의후,장90례당뇨병족환자채용수자표법수궤분위연구조、고압양조화전렬지이조,매조30례.3조균여이당뇨병음식、강혈당약물、영양신경、국부창면처리등상규치료.연구조재차기출상,응용전렬지이20 μg가입생리염수100 ml정맥적주,1차/d,동시채용다인고압양창치료,압력위0.20 MPa,1차/d,10차위1개료정；고압양조재상규치료적기출상,채용고압양치료,치료방법동연구조；전렬지이조재상규치료적기출상사용전렬지이20μg가입생리염수100 ml정맥적주,1차/d.치료4개료정후진행림상료효평정.결과 연구조、고압양조화전렬지이조총유효솔분별위93.3％ (28/30)、76.7％(23/30)、70.0％(21/30),전자여후량자비교차이균유통계학의의(P＜0.05).결론 고압양연합전렬지이치료당뇨병족유리우하지동맥혈공、양공,개선미순배,제고궤양유합솔,시치료당뇨병족적유효방안.
Objective To study the clinical effect of hyperbaric oxygen (HBO) combined with liposomal alprostadil (Lipo-PGE1) in the treatment of diabetic foot.Methods Ninety patients with diabetic foot were randomly divided into the study group (HBO + liposomal alprostadil),the HBO group and the liposomal alprostadil group,each consisting of 30 cases.The patients of the 3 groups all received routine treatment,such as diabetic diet,hypoglycemic agent,trophic nerve and wound surface management.In addition to the routine treatment mentioned above,the patients in the study group received 20 μg intravenous drip diluted with 100 ml saline solution,once a day.At the same time,they had HBO therapy at a pressure of 0.2 MPa,once a day,10 sessions a treatment course.In addition to the same routine treatment,the HBO group received HBO therapy also at a pressure of 0.2 MPa,once a day,10 sessions a treatment course.With the same routine treatment mentioned above,the liposomal alprostadil group only received 20 μg intravenous drip diluted with 100 ml saline solution,once a day.After 4 treatment courses,therapeutic effects on the patients of the 3 groups were evaluated respectively.Results Following treatment,total effective rates for the study group,the HBO group and the liposomal alprostadil group were 93.3％,76.7％ and 70.0％ respectively.Significant differences in therapeutic effects could be noted,when the former was compared with the latter two groups (P ＜ 0.05).Conclusions In the treatment of diabetic foot,HBO coupled with liposomal alprostadil could improve blood and oxygen supplies to the lower limbs,enhance microcirculation,increase healing rate of ulcers,and it was surely an effective treatment strategy for the treatment of diabetic foot.