CAJ | 학술논문

目的探讨二次经尿道等离子体电切术(PKRBT)降低中高危非肌层浸润性膀胱癌术后肿瘤复发率的临床研究.方法选取2010年1月至2012年4月已经行第一次PKRBT的中高危非肌层浸润性膀胱癌患者62例,随机分为实验组和对照组,实验组于第一次PKRBT术后4～6周行二次PKRBT,两组均在PKRBT术后开始辅助性膀胱灌注化疗;每三个月返院复查膀胱镜一次,两组均随访20个月,评估两组肿瘤复发率.结果随访20个月,实验组复发率19.4％,对照组复发率41.9％,实验组复发率较对照组显著降低,差异有统计学意义(P＜0.05).结论中高危非肌层浸润性膀胱癌患者行二次经尿道等离子体电切术及术后辅助性膀胱灌注化疗,能有效降低肿瘤复发率,并可获得更准确的病理分期.
목적 탐토이차경뇨도등리자체전절술(PKRBT)강저중고위비기층침윤성방광암술후종류복발솔적림상연구.방법 선취2010년1월지2012년4월이경행제일차PKRBT적중고위비기층침윤성방광암환자62례,수궤분위실험조화대조조,실험조우제일차PKRBT술후4～6주행이차PKRBT,량조균재PKRBT술후개시보조성방광관주화료;매삼개월반원복사방광경일차,량조균수방20개월,평고량조종류복발솔.결과 수방20개월,실험조복발솔19.4％,대조조복발솔41.9％,실험조복발솔교대조조현저강저,차이유통계학의의(P＜0.05).결론 중고위비기층침윤성방광암환자행이차경뇨도등리자체전절술급술후보조성방광관주화료,능유효강저종류복발솔,병가획득경준학적병리분기.
Objective To assess the clinical study of the repeat transurethral plasmakinetic resection of the bladder tumor (PKRBT) in preventing the recurrence rate of the high risk non muscle invasive bladder cancer (NMIBC).Methods 62 cases of high risk NMIBC treated by the first PKRBT were selected as the study objects from January 2010 to April 2012 and were randomly divided into experiment group and control group.Experiment group was treated by the repeat PKRBT for 4-6 weeks after the interval of the first resection,two groups were treated with adjuvant intravesical chemotherapy when finished resection.All of them were given a cystoscopy every three months and were followed up for 20 months,then we evaluated the tumor recurrence rates of the two groups.Results After 20 months of the following up in two groups,the recurrence rate of experiment group was 19.4％ and 41.9％ in control group,there was a significant reduction in experiment group compared with control group,the difference was statistically significant (P ＜ 0.05).Conclusion The tumor recurrence rate can been reduced when the patients with high risk NMIBC accept the repeat PKRBT and adjuvant intravesical chemotherapy after resection,and we can obtain more accurate pathological staging by it.