国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
7期
938-940
,共3页
血清基质金属蛋白酶-9%进展性缺血性脑卒中%相关性
血清基質金屬蛋白酶-9%進展性缺血性腦卒中%相關性
혈청기질금속단백매-9%진전성결혈성뇌졸중%상관성
Matrix metalloproteinase-9%Progressive ischemic stroke%Correlation
目的 探讨血清基质金属蛋白酶-9(MMP-9)和进展性缺血性脑卒中的相关性.方法 30例进展性缺血性脑卒中病人为PIS组,30例门诊非进展性缺血性脑卒中病人为非PIS组,30例门诊体检健康者作为对照组.通过ELISA法测定各组患者的MMP-9含量来分析MMP-9和进展性缺血性脑卒中的相关性.结果 第2d、第7d,与对照组、非PIS组对比,PIS组的MMP-9含量在同一时间点要高于其余两组(P＜0.05);且非PIS组的MMP-9含量明显高于对照组(P＜0.05).经过直线回归分析可知,PIS组中随着MMP-9水平不断升高,PIS的危险性呈现升高趋势.结论 MMP-9水平与进展性缺血性脑卒中具有正相关性,MMP-9含量升高,PIS的危险性呈升高趋势.MMP-9是进展性缺血性脑卒中的危险因素,值得重视.
目的 探討血清基質金屬蛋白酶-9(MMP-9)和進展性缺血性腦卒中的相關性.方法 30例進展性缺血性腦卒中病人為PIS組,30例門診非進展性缺血性腦卒中病人為非PIS組,30例門診體檢健康者作為對照組.通過ELISA法測定各組患者的MMP-9含量來分析MMP-9和進展性缺血性腦卒中的相關性.結果 第2d、第7d,與對照組、非PIS組對比,PIS組的MMP-9含量在同一時間點要高于其餘兩組(P＜0.05);且非PIS組的MMP-9含量明顯高于對照組(P＜0.05).經過直線迴歸分析可知,PIS組中隨著MMP-9水平不斷升高,PIS的危險性呈現升高趨勢.結論 MMP-9水平與進展性缺血性腦卒中具有正相關性,MMP-9含量升高,PIS的危險性呈升高趨勢.MMP-9是進展性缺血性腦卒中的危險因素,值得重視.
목적 탐토혈청기질금속단백매-9(MMP-9)화진전성결혈성뇌졸중적상관성.방법 30례진전성결혈성뇌졸중병인위PIS조,30례문진비진전성결혈성뇌졸중병인위비PIS조,30례문진체검건강자작위대조조.통과ELISA법측정각조환자적MMP-9함량래분석MMP-9화진전성결혈성뇌졸중적상관성.결과 제2d、제7d,여대조조、비PIS조대비,PIS조적MMP-9함량재동일시간점요고우기여량조(P＜0.05);차비PIS조적MMP-9함량명현고우대조조(P＜0.05).경과직선회귀분석가지,PIS조중수착MMP-9수평불단승고,PIS적위험성정현승고추세.결론 MMP-9수평여진전성결혈성뇌졸중구유정상관성,MMP-9함량승고,PIS적위험성정승고추세.MMP-9시진전성결혈성뇌졸중적위험인소,치득중시.
Objective To investigate the correlation between serum matrix metalloproteinase-9 (MMP-9) and progressive ischemic stroke (PIS).Methods 30 cases of PIS patients were selected as PIS group,30 cases of outpatient non-ischemic stroke patients were chosen as non-PIS group,and 30 cases of outpatient healthy people were selected as control group.Patients' MMP-9 in each group was measured by ELISA method to analyze the correlation of MMP-9 and PIS.Results Comparing control group and non-PIS group at the 2nd day and 7th day,MMP-9 levels in PIS group at the same point were higher than those of the other two groups (P ＜ 0.05).MMP-9 levels in non-PIS group at the 2nd day and 7th day were higher than those of control group (P ＜ 0.05).Linear regression analysis showed that,with MMP-9 levels rising in PIS group,the danger of PIS presented an increasing trend.Conclusion MMP-9 level and PIS have a positive correlation.With MMP-9 level increasing,the danger of PIS presents an increasing trend.MMP-9 is a risk factor for ischemic stroke in progress,and it is worthy of attention.
