CAJ | 학술논문

目的建立基于脑功能连接网络的~(18)F-脱氧葡萄糖(FDG)PET脑图像分析方法 ,并利用该方法分析海马区功能连接网络随年龄的变化.方法将195名健康志愿者按年龄分为4组:31~40岁组50名,41~50岁组50名,51~60岁组50名,61~78岁组45名.分别采集静息状态下的脑部~(18)F-FDG PET图像,利用统计参数图(SPM)对图像进行归一化处理,提取功能脑区,并利用相关性分析,得到与海马区存在有功能连接的脑区,构建出海马的功能连接网络.结果各年龄组的海马-脑区功能连接存在差异.上述4个年龄组的左海马连接率分别为12%、11%、9%和8%,与年龄之间的相关系数(r)=-0.9726,P=0.0241;全海马的连接率分别为16%、11%、10%和10%,与年龄之间的r=-0.8157,P=0.1829.结论随着年龄的增加,海马区与其他脑区的连接功能明显下降,与海马的生理性变化相一致,表明脑功能连接的方法可以有效地用于~(18)F-FDG PET脑图像分析.
목적 건립기우뇌공능련접망락적~(18)F-탈양포도당(FDG)PET뇌도상분석방법 ,병이용해방법 분석해마구공능련접망락수년령적변화.방법 장195명건강지원자안년령분위4조:31~40세조50명,41~50세조50명,51~60세조50명,61~78세조45명.분별채집정식상태하적뇌부~(18)F-FDG PET도상,이용통계삼수도(SPM)대도상진행귀일화처리,제취공능뇌구,병이용상관성분석,득도여해마구존재유공능련접적뇌구,구건출해마적공능련접망락.결과 각년령조적해마-뇌구공능련접존재차이.상술4개년령조적좌해마련접솔분별위12%、11%、9%화8%,여년령지간적상관계수(r)=-0.9726,P=0.0241;전해마적련접솔분별위16%、11%、10%화10%,여년령지간적r=-0.8157,P=0.1829.결론 수착년령적증가,해마구여기타뇌구적련접공능명현하강,여해마적생이성변화상일치,표명뇌공능련접적방법 가이유효지용우~(18)F-FDG PET뇌도상분석.
Objective The purpose of this study was to establish the methodology in which ~(18)F-fluorodeoxyglucose(FDG)brain PET images could be analyzed based on funetional connectivity,and to further evaluate the age-related changes offunctional network in the hippoeampus.Methods In this study,195 healthy volunteers were euroUed and divided into 4 groups by age(31-40 years,n=50:41-50 years,n=50;51-60 years,n=50;61-78 years,n=45).~(18)F-FDG PET was performed in a resting state.The funetional connectivity between hippocampus and other cortical and sub-cortical regions was delineated by using the statistical parametric mapping(SPM)method to analyze their relative correlation significance and to construct a functional connectivity network of the hippocampus with these regions.Results The factor of age did affect the connectivity pairs of the hippocampus functional network.The connectivity rates of left hippocampns(CR_L)of the 4 groups were 12%,11%,9%and 8%,respectively;the corte-lation coefficients(r)between CR_L and age was-0.9726,P=0.0241;the connectivity rates of the whole hippocampus(CR_A)were 16%,11%,10%and 10%,respectively;r between CR_A and age was-0.8157.P=0.1829.Condusions It is feasible to analyze the hippocampns functional connectivity network by FDG PET images and SPM.The functional connective ability of hippocampus decreases with age,which is consistent with the observed physiological change of the hippocampus.