CAJ | 학술논문

目的观察对比单纯~(90)Sr-~(90)Y敷贴和瘢痕内切除术后帅~(90)Sr-~(90)Y敷贴治疗大面积病理性瘢痕的疗效.方法选取临床确诊的大面积病理性瘢痕患者158例,共196块病理性瘢痕,按瘢痕厚度分为A、B、C 3组,每组患者再采用简单随机法分为两部分,分别接受单纯~(90)Sr-~(90)Y敷贴治疗(102块)和瘢痕内切除术并~(90)Sr-~(90)Y敷贴治疗(94块),治疗结束后2年评价疗效,行Ridit分析.结果瘢痕内切除术并~(90)Sr-~(90)Y敷贴的疗效明显优于单纯~(90)Sr-~(90)Y敷贴治疗(R=0.428和0.578,F=92.6,P<0.01),前者疗效不受瘢痕厚度的影响,后者疗效则明显受瘢痕厚度影响.结论对于瘢痕表面积和厚度较大的病理性瘢痕患者,宜采用瘢痕内切除术并~(90)Sr-~(90)Y敷贴治疗.
목적 관찰대비단순~(90)Sr-~(90)Y부첩화반흔내절제술후수~(90)Sr-~(90)Y부첩치료대면적병이성반흔적료효.방법 선취림상학진적대면적병이성반흔환자158례,공196괴병이성반흔,안반흔후도분위A、B、C 3조,매조환자재채용간단수궤법분위량부분,분별접수단순~(90)Sr-~(90)Y부첩치료(102괴)화반흔내절제술병~(90)Sr-~(90)Y부첩치료(94괴),치료결속후2년평개료효,행Ridit분석.결과 반흔내절제술병~(90)Sr-~(90)Y부첩적료효명현우우단순~(90)Sr-~(90)Y부첩치료(R=0.428화0.578,F=92.6,P<0.01),전자료효불수반흔후도적영향,후자료효칙명현수반흔후도영향.결론 대우반흔표면적화후도교대적병이성반흔환자,의채용반흔내절제술병~(90)Sr-~(90)Y부첩치료.
Objective Pathological scars including hypertophic scars and keloids were the results of excessive fibroblast proliferation and abundant collagen deposition.The aim of this study was to investigate the value of Scar endo-ectomy combined ~(90)Sr-~(90)Y applicator brachytherapy for large pathological scar.Methods A total of 158 large area pathological Scar patients with 196 pieces of scars were divided into 3 groups.There were A,B and C,based on the thickness of pathological Scar.Of these three groups,they were randomly divided into two subgroups.One was treated by ~(90)Sr-~(90)Y applicator brachytherapy alone (n=102)and the other(n=94)was treated by endo-ectomy combined ~(90)Sr-~(90)Y applicator brachytherapy.All had clinical follow-up for at least 2 years to monitor the therapeutic outcomes.Results were analyzed by ref-erence identical unit(Ridit).Results A significant better outcome was observed in patients with endo-ec-tomy combined ~(90)Sr-~(90)Y applicator brachytherapy than with ~(90)Sr-~(90)Y applicator brachytherapy alone (R=0.428 and 0.578,F=92.6,P<0.01).Thickness of pathological sears controlled the therapeutic effects for the later treatment but the former.Conclusion As to the scars with large area and thickness,scar endo-ectomy combined ~(90)Sr-~(90)Y applicator brachytherapy was recommended.