中华核医学杂志
中華覈醫學雜誌
중화핵의학잡지
CHINESE JOURNAL OF NUCLEAR MEDICINE
2011年
6期
378-381
,共4页
朱婉琦%于金明%孙晓蓉%邢立刚%谢鹏%孙新东%郭洪波%杨国仁%孔莉
硃婉琦%于金明%孫曉蓉%邢立剛%謝鵬%孫新東%郭洪波%楊國仁%孔莉
주완기%우금명%손효용%형립강%사붕%손신동%곽홍파%양국인%공리
食管肿瘤%预后%体层摄影术,发射型计算机%体层摄影术,X线计算机%脱氧葡萄糖
食管腫瘤%預後%體層攝影術,髮射型計算機%體層攝影術,X線計算機%脫氧葡萄糖
식관종류%예후%체층섭영술,발사형계산궤%체층섭영술,X선계산궤%탈양포도당
Esophageal neoplasms%Prognosis%Tomography,emission-computed%Tomography,X-ray computed%Deoxyglucose
目的 研究食管癌患者18F-FDG PET/CT MTV与预后的关系.方法 回顾性分析2004年3月至2008年3月行18 F-FDG PET/CT检查的49例Ⅰ～Ⅳa期的食管癌患者,均经病理检查证实,随访资料完整.患者均行食管癌切除术,随访截止至2009年11月,中位随访时间为29(8～57)个月.应用Kaplan-Meier法及Cox比例风险模型分析年龄、性别、肿瘤位置、肿瘤组织分化程度、PET/CT示肿瘤长径、美国肿瘤联合会(AJCC)分期、转移淋巴结个数、原发灶SUVmax及MTV与预后的关系.结果 在单因素分析中,仅AJCC分期[x2=16.206,危险比(HR)=1.177,P＜0.001),淋巴结分期(N) (x2=9.536,HR=10.833,P=0.002),浸润深度(T)(x2=5.810,HR=2.397,P=0.016),淋巴结转移个数(x2=11.423,HR=1.567,P=0.001)、MTV(x2=3.872,HR=2.433,P=0.049)对预后存在预测作用.对以上变量行多因素分析,仅AJCC分期及MTV是独立的预后因子(x2 =4.525,HR=1.170,P=0.033;x2 =4.875,HR=3.071,P=0.027).Kaplan-Meier生存分析显示术前低MTV组比高MTV组的生存率高(Log-rank检验,x2=4.186,P=0.041).结论 MTV与食管癌术后患者的预后密切相关.对于高MTV患者,术后可能需要接受更加积极的治疗.
目的 研究食管癌患者18F-FDG PET/CT MTV與預後的關繫.方法 迴顧性分析2004年3月至2008年3月行18 F-FDG PET/CT檢查的49例Ⅰ～Ⅳa期的食管癌患者,均經病理檢查證實,隨訪資料完整.患者均行食管癌切除術,隨訪截止至2009年11月,中位隨訪時間為29(8～57)箇月.應用Kaplan-Meier法及Cox比例風險模型分析年齡、性彆、腫瘤位置、腫瘤組織分化程度、PET/CT示腫瘤長徑、美國腫瘤聯閤會(AJCC)分期、轉移淋巴結箇數、原髮竈SUVmax及MTV與預後的關繫.結果 在單因素分析中,僅AJCC分期[x2=16.206,危險比(HR)=1.177,P＜0.001),淋巴結分期(N) (x2=9.536,HR=10.833,P=0.002),浸潤深度(T)(x2=5.810,HR=2.397,P=0.016),淋巴結轉移箇數(x2=11.423,HR=1.567,P=0.001)、MTV(x2=3.872,HR=2.433,P=0.049)對預後存在預測作用.對以上變量行多因素分析,僅AJCC分期及MTV是獨立的預後因子(x2 =4.525,HR=1.170,P=0.033;x2 =4.875,HR=3.071,P=0.027).Kaplan-Meier生存分析顯示術前低MTV組比高MTV組的生存率高(Log-rank檢驗,x2=4.186,P=0.041).結論 MTV與食管癌術後患者的預後密切相關.對于高MTV患者,術後可能需要接受更加積極的治療.
목적 연구식관암환자18F-FDG PET/CT MTV여예후적관계.방법 회고성분석2004년3월지2008년3월행18 F-FDG PET/CT검사적49례Ⅰ～Ⅳa기적식관암환자,균경병리검사증실,수방자료완정.환자균행식관암절제술,수방절지지2009년11월,중위수방시간위29(8～57)개월.응용Kaplan-Meier법급Cox비례풍험모형분석년령、성별、종류위치、종류조직분화정도、PET/CT시종류장경、미국종류연합회(AJCC)분기、전이림파결개수、원발조SUVmax급MTV여예후적관계.결과 재단인소분석중,부AJCC분기[x2=16.206,위험비(HR)=1.177,P＜0.001),림파결분기(N) (x2=9.536,HR=10.833,P=0.002),침윤심도(T)(x2=5.810,HR=2.397,P=0.016),림파결전이개수(x2=11.423,HR=1.567,P=0.001)、MTV(x2=3.872,HR=2.433,P=0.049)대예후존재예측작용.대이상변량행다인소분석,부AJCC분기급MTV시독립적예후인자(x2 =4.525,HR=1.170,P=0.033;x2 =4.875,HR=3.071,P=0.027).Kaplan-Meier생존분석현시술전저MTV조비고MTV조적생존솔고(Log-rank검험,x2=4.186,P=0.041).결론 MTV여식관암술후환자적예후밀절상관.대우고MTV환자,술후가능수요접수경가적겁적치료.
Objective To evaluate the prognostic value of MTV on 18F-FDG PET/CT in patients with esophageal cancer.Methods Forty-nine patients with esophageal cancer underwent 18 F-FDG PET/CT scan before surgery.The median follow-up time for the patients was 29 months (range,8- 57 months).The prognostic significance of MTV,age,sex,histologic grade,SUVmax of the primary tumor,tumor size measured on PET/CT,T stage,N stage,M stage,American Joint Committee on Cancer (AJCC) stage,number and location of lymph nodes metastases were assessed by Kaplan-Meier analysis and multivariate Cox model.Results In the univariate analysis,AJCC stage (x2 =16.206,hazard ratio (HR) =1.177,P ＜0.001),N stage (x2 =9.536,HR =10.833,P =0.002),T stage (x2 =5.810,HR=2.397,P=0.016),number of lymph nodes metastases (x2 =11.423,HR =1.567,P =0.001 ),and MTV (x2 =3.872,HR =2.433,P =0.049 ) were significant predictors of survival.Multivariate analysis showed that MTV and AJCC stage were independent predictors of survival (x2 =4.525,HR 1.170,P =0.033 ; X2=4.875,HR =3.071,P =0.027).Kaplan-Meier survival curves revealed longer survival time of low-MTV group as compared to high-MTV group ( Log-rank,x2 =4.186,P =0.041 ).Conclusion MTV on 18 F-FDG PET/CT may be an independent prognostic factor in patients with esophageal cancer.
