中华核医学与分子影像杂志
中華覈醫學與分子影像雜誌
중화핵의학여분자영상잡지
Chinese Journal of Nuclear Medicine and Molecular Imaging
2013年
1期
49-51
,共3页
血管瘤%婴儿%普萘洛尔%近距离放射疗法%锶放射性同位素%钇放射性同位素
血管瘤%嬰兒%普萘洛爾%近距離放射療法%鍶放射性同位素%釔放射性同位素
혈관류%영인%보내락이%근거리방사요법%송방사성동위소%을방사성동위소
Hemangioma%Infant%Propranolol%Brachytherapy%Strontium radioisotopes%Yttrium radioisotopes
目的 探讨90Sr-90Y敷贴联合普萘洛尔治疗婴幼儿大面积皮肤血管瘤的临床疗效.方法 将39例婴幼儿大面积皮肤血管瘤患儿按随机数字表法分为2组,进行前瞻性研究:观察组18例,采用90Sr-90Y敷贴治疗同时给予普萘洛尔口服；对照组21例,单纯采用90Sr-90Y敷贴治疗.对比观察2组患儿疗效,并对相关数据行秩和检验及x2检验.结果 观察组治愈率为44.4％ (8/18),好转率为55.6％ (10/18),有效率为100.0％ (18/18),加重率为0(0/18)；对照组治愈率为14.3％ (3/21),好转率为52.4％(11/21),有效率为66.7％(14/21),加重率为19.0％ (4/21).观察组疗效优于对照组(Z=-2.861,P＜0.05)；观察组1周内见效率为72.2％(13/18),高于对照组(14.3％,3/21；x2=13.447,P＜O.05)；观察组不良反应发生率为66.7％(12/18),高于对照组(19.0％,4/21;x2=9.084,P＜0.05).结论 普萘洛尔联合90Sr-90Y治疗婴幼儿大面积皮肤血管瘤具有较好的临床疗效,但必须密切监测不良反应的发生.
目的 探討90Sr-90Y敷貼聯閤普萘洛爾治療嬰幼兒大麵積皮膚血管瘤的臨床療效.方法 將39例嬰幼兒大麵積皮膚血管瘤患兒按隨機數字錶法分為2組,進行前瞻性研究:觀察組18例,採用90Sr-90Y敷貼治療同時給予普萘洛爾口服；對照組21例,單純採用90Sr-90Y敷貼治療.對比觀察2組患兒療效,併對相關數據行秩和檢驗及x2檢驗.結果 觀察組治愈率為44.4％ (8/18),好轉率為55.6％ (10/18),有效率為100.0％ (18/18),加重率為0(0/18)；對照組治愈率為14.3％ (3/21),好轉率為52.4％(11/21),有效率為66.7％(14/21),加重率為19.0％ (4/21).觀察組療效優于對照組(Z=-2.861,P＜0.05)；觀察組1週內見效率為72.2％(13/18),高于對照組(14.3％,3/21；x2=13.447,P＜O.05)；觀察組不良反應髮生率為66.7％(12/18),高于對照組(19.0％,4/21;x2=9.084,P＜0.05).結論 普萘洛爾聯閤90Sr-90Y治療嬰幼兒大麵積皮膚血管瘤具有較好的臨床療效,但必鬚密切鑑測不良反應的髮生.
목적 탐토90Sr-90Y부첩연합보내락이치료영유인대면적피부혈관류적림상료효.방법 장39례영유인대면적피부혈관류환인안수궤수자표법분위2조,진행전첨성연구:관찰조18례,채용90Sr-90Y부첩치료동시급여보내락이구복；대조조21례,단순채용90Sr-90Y부첩치료.대비관찰2조환인료효,병대상관수거행질화검험급x2검험.결과 관찰조치유솔위44.4％ (8/18),호전솔위55.6％ (10/18),유효솔위100.0％ (18/18),가중솔위0(0/18)；대조조치유솔위14.3％ (3/21),호전솔위52.4％(11/21),유효솔위66.7％(14/21),가중솔위19.0％ (4/21).관찰조료효우우대조조(Z=-2.861,P＜0.05)；관찰조1주내견효솔위72.2％(13/18),고우대조조(14.3％,3/21；x2=13.447,P＜O.05)；관찰조불량반응발생솔위66.7％(12/18),고우대조조(19.0％,4/21;x2=9.084,P＜0.05).결론 보내락이연합90Sr-90Y치료영유인대면적피부혈관류구유교호적림상료효,단필수밀절감측불량반응적발생.
Objective To investigate the clinical efficacy of 90Sr-90Y applicator combined with propranolol (inderal) treatment for infants with large areas of cutaneous hemangiomas.Methods Thirty-nine infants with large areas of cutaneous hemangiomas were randomly divided into two groups:study group (n =18) treated with 90Sr-90Y applicator in conjunction with propranolol,and control group (n =21) treated by 90Sr-90Y applicator only.The results of curative effects between the two groups were analyzed using rank sum test and x2 test.Results The cure rate,remission rate and effective rate for the study group were 44.4％(8/18),55.6 ％ (10/18) and 100.0％ (18/18),respectively,and the corresponding rates for the control group were 14.3％ (3/21),52.4％ (11/21) and 66.7％ (14/21),respectively.The effective rate in the study group was significantly higher than that in the control group (Z =-2.861,P ＜ 0.05).The adverse reaction rates in the study and control groups were 66.7％ (12/18) and 19.0％ (4/21 ;x2 =9.084,P ＜0.05),respectively.Conclusion Combined propranolol with 90Sr-90Y treatment for large infantile hemangiomas is clinically effective,but its side effects should be closely monitored.
