CAJ | 학술논문

目的探讨CT引导下经皮穿刺125I粒子植入治疗肺转移癌的临床应用价值及安全性.方法 27例肺转移癌患者中肝癌肺转移18例(46个结节),前列腺癌肺转移4例(9个结节),乳腺癌肺转移5例(12个结节).共67个结节,结节直径0.5 ～4.0(平均2.1)cm.在CT定位下植入125I粒子2～ 33粒/例,粒子活度为18.5 ～29.6 MBq/粒,肿瘤匹配周边吸收剂量为90～120 Gy,术后进行验证和质量评估.结果随访4个月,67个结节中CR 24个,PR 30个,NC 5个,PD 8个,总有效率达80.6％ (54/67).11例次出现不同程度气胸,其中3例次较重,术中胸腔穿刺后好转,较轻者密切随诊观察直至气体吸收；4例次出现痰中带血,对症处理后好转.结论 CT引导下经皮穿刺125I粒子植入治疗肺转移癌疗效肯定.CT定位准确,安全性较高.
목적 탐토CT인도하경피천자125I입자식입치료폐전이암적림상응용개치급안전성.방법 27례폐전이암환자중간암폐전이18례(46개결절),전렬선암폐전이4례(9개결절),유선암폐전이5례(12개결절).공67개결절,결절직경0.5 ～4.0(평균2.1)cm.재CT정위하식입125I입자2～ 33립/례,입자활도위18.5 ～29.6 MBq/립,종류필배주변흡수제량위90～120 Gy,술후진행험증화질량평고.결과 수방4개월,67개결절중CR 24개,PR 30개,NC 5개,PD 8개,총유효솔체80.6％ (54/67).11례차출현불동정도기흉,기중3례차교중,술중흉강천자후호전,교경자밀절수진관찰직지기체흡수；4례차출현담중대혈,대증처리후호전.결론 CT인도하경피천자125I입자식입치료폐전이암료효긍정.CT정위준학,안전성교고.
Objective To explore the clinical application and safety of treatment of percutaneous radioactive 125I seed implantation treatment in lung metastases under CT guidance.Methods Twenty-seven lung metastatic malignancy cases (67 nodules) were studied.Eighteen cases (46 nodules) were hepatic cancer,4 cases (9 nodules) were prostate cancer,and 5 cases (12 nodules) were breast carcinoma.Diameters of lung nodules ranged from 0.5 cm to 4.0 cm with an average diameter of 2.1 cm.125I seeds were embedded under CT guidance,using 2 to 33 particles/nodule with an activity of 18.5 to 29.6 MBq/grain for each particle.Tumor matched peripheral dose was 90-120 Gy.Postoperative validation and quality evaluation followed.Results Four months later,24 nodules showed CR,30 showed PR,5 showed NC and 8 showed PD.The total effective rate was 80.6％ (54/67).In the course of treatment,11 patients had pneumothorax,3 had heavy lung compression and 4 had hemoptysis.All conditions were improved by pleural puncture or under close follow-up observation.Conclusion 125I seed implantation is an effective and safe technique in treatment of metastatic lung tumors under CT guidance.