国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
7期
971-974
,共4页
梅清华%范翠琼%杨茵%李明友%林茂锐
梅清華%範翠瓊%楊茵%李明友%林茂銳
매청화%범취경%양인%리명우%림무예
耐药菌%糖尿病足%药敏%物理抗微生物膜%抗菌药物
耐藥菌%糖尿病足%藥敏%物理抗微生物膜%抗菌藥物
내약균%당뇨병족%약민%물리항미생물막%항균약물
Drug-resistant strains%Diabetic foot%Susceptibility%Physical Antimicrobial Film%Antibiotics
目的 研究创新物理抗微生物膜对临床糖尿病足耐药菌株的药敏情况.方法 对168例糖尿病足感染患者行病原菌分离培养,以最低抑菌浓度(MIC)稀释法进行药敏试验,比较常用抗菌药物及物理抗微生物膜的耐药情况.结果 分离出的63株菌株按构成比例由多到少依次为:金黄色葡萄球菌、铜绿假单胞菌、产气肠杆菌、阴沟肠杆菌、不动杆菌、表皮葡萄球菌.金黄色葡萄球菌对青霉素、左氧氟沙星、氨苄西林、苯唑西林、哌拉西林、庆大霉素、头孢唑林、头孢他啶等8种抗菌药物耐药率为23.5％～100％;铜绿假单胞菌为23.5％～97.8％;产气肠杆菌为7.5％～75.3％;阴沟肠杆菌为30.5％ ～ 94.6％;不动杆菌为21.6％ ～ 94.6％;表皮葡萄球菌为5.6％～83.8％.以上6种分离菌对物理抗微生物膜耐药率为0.结论 物理抗微生物膜具有广谱抗菌,对各种细菌敏感率高的特点,为临床治疗糖尿病足提供了有效,而且可避免耐药的物理学抗感染新方法.
目的 研究創新物理抗微生物膜對臨床糖尿病足耐藥菌株的藥敏情況.方法 對168例糖尿病足感染患者行病原菌分離培養,以最低抑菌濃度(MIC)稀釋法進行藥敏試驗,比較常用抗菌藥物及物理抗微生物膜的耐藥情況.結果 分離齣的63株菌株按構成比例由多到少依次為:金黃色葡萄毬菌、銅綠假單胞菌、產氣腸桿菌、陰溝腸桿菌、不動桿菌、錶皮葡萄毬菌.金黃色葡萄毬菌對青黴素、左氧氟沙星、氨芐西林、苯唑西林、哌拉西林、慶大黴素、頭孢唑林、頭孢他啶等8種抗菌藥物耐藥率為23.5％～100％;銅綠假單胞菌為23.5％～97.8％;產氣腸桿菌為7.5％～75.3％;陰溝腸桿菌為30.5％ ～ 94.6％;不動桿菌為21.6％ ～ 94.6％;錶皮葡萄毬菌為5.6％～83.8％.以上6種分離菌對物理抗微生物膜耐藥率為0.結論 物理抗微生物膜具有廣譜抗菌,對各種細菌敏感率高的特點,為臨床治療糖尿病足提供瞭有效,而且可避免耐藥的物理學抗感染新方法.
목적 연구창신물리항미생물막대림상당뇨병족내약균주적약민정황.방법 대168례당뇨병족감염환자행병원균분리배양,이최저억균농도(MIC)희석법진행약민시험,비교상용항균약물급물리항미생물막적내약정황.결과 분리출적63주균주안구성비례유다도소의차위:금황색포도구균、동록가단포균、산기장간균、음구장간균、불동간균、표피포도구균.금황색포도구균대청매소、좌양불사성、안변서림、분서서림、고랍서림、경대매소、두포서림、두포타정등8충항균약물내약솔위23.5％～100％;동록가단포균위23.5％～97.8％;산기장간균위7.5％～75.3％;음구장간균위30.5％ ～ 94.6％;불동간균위21.6％ ～ 94.6％;표피포도구균위5.6％～83.8％.이상6충분리균대물리항미생물막내약솔위0.결론 물리항미생물막구유엄보항균,대각충세균민감솔고적특점,위림상치료당뇨병족제공료유효,이차가피면내약적물이학항감염신방법.
Objective To study susceptibility of innovative physical method against resistant strains isolated from clinical diabetic foot.Methods Pathogens from 168 cases of patients with diabetic foot infections were isolated and cultured,minimum inhibitory concentration (MIC) dilution method was adopted for susceptibility test to compare drug resistance of Physical Antimicrobial Film and common antibiotics.Results 63 strains were cultured and isolated from affected parts of diabetic foot patients.According to ratio,the strains from the maximum to minimum were:Staphylococcus aureus,Pseudomonas aeruginosa,Enterobacter aerogenes,Enterobacter cloacae,Acinetobacter,Staphylococcus epidermidis.The drug-resistant rates of Staphylococcus aureus to penicillin,levofloxacin,ampicillin,oxacillin,piperacillin,gentamicin,cefazolin,ceftazidime were 23.5％ to 100％; those of Pseudomonas aeruginosa to eight antibiotics were 23.5％ to 97.8％;those of Enterobacter aerogenes to eight antibiotics were 7.5％ to 75.3％; those of Enterobacter cloacae to eight antibiotics were 30.5％ to 94.6％; those of Acinetobacter to eight antibiotics were 21.6％ to 94.6％;those of Staphylococcus epidermidis to eight antibiotics were 5.6％ to 83.8％.The drug-resistant rates of the above six isolated strains to Physical Antimicrobial Film JUC Spray Dressing were 0.Conclusion Physical Antimicrobial Film has the characteristics of broad-spectrum antimicrobe,with high sensitive rates to a variety of bacteria.It provides a new effective anti-infective physics (not chemical or biological) method and can avoid drug resistance for the clinical treatment of diabetic foot.
