中华核医学与分子影像杂志
中華覈醫學與分子影像雜誌
중화핵의학여분자영상잡지
Chinese Journal of Nuclear Medicine and Molecular Imaging
2013年
5期
355-357
,共3页
袁杰%张光明%刘从进%王渊恺%朱汇庆%蒯大禹%吴霞%胡仁明%刘兴党
袁傑%張光明%劉從進%王淵愷%硃彙慶%蒯大禹%吳霞%鬍仁明%劉興黨
원걸%장광명%류종진%왕연개%주회경%괴대우%오하%호인명%류흥당
糖尿病肾病%肾小球滤过率%Gates法%放射性核素显像%DTPA
糖尿病腎病%腎小毬濾過率%Gates法%放射性覈素顯像%DTPA
당뇨병신병%신소구려과솔%Gates법%방사성핵소현상%DTPA
Diabetic nephropathies%Glomerular filtration rate%Gates method%Radionuclide imaging%DTPA
目的 探讨2型糖尿病肾病患者99Tcm-DTPA GFR测定的时间影响及GFR对2型糖尿病肾功能异常早期诊断的临床意义.方法 招募健康志愿者11名,其中男6名,女5名,年龄47～79(61.45±7.90)岁；社区2型糖尿病肾病患者56例,其中男31例,女25例,年龄45～75(60.98±6.96)岁,均应用99Tcm-DTPA肾动态显像测定GFR.分别取注药后第2分钟和第3分钟图像勾画ROI,根据Gates分析方法,计算总肾及分肾GFR.利用SPSS 15.0软件对数据进行Pearson相关分析和两样本t检验.结果 2型糖尿病肾病患者的GFR与SCr[(84.90±14.38) μnol/L]呈负相关:注射99Tcm-DTPA后第2分钟双肾、左肾和右肾GFR均与SCr呈负相关(r=-0.599、-0.553和-0.529,均P＜0.001)；第3分钟双肾、左肾和右肾GFR也均与SCr呈负相关(r=-0.652、-0.636和-0.470,均P≤0.001).2型糖尿病肾病患者双肾、左肾和右肾第3分钟GFR分别为(69.77±11.00)、(33.12±5.74)和(37.34±9.81) ml/min,低于健康对照组[(97.89±5.98)、(46.60±4.91)和(51.28±4.20) ml/min；t=-8.212、-7.233和-4.069,均P＜0.001].结论 建议对2型糖尿病肾病患者选择注射99Tcm-DTPA后第3分钟的放射性计数测定GFR;GFR测定对糖尿病肾病患者肾功能异常早期诊断具有重要意义.
目的 探討2型糖尿病腎病患者99Tcm-DTPA GFR測定的時間影響及GFR對2型糖尿病腎功能異常早期診斷的臨床意義.方法 招募健康誌願者11名,其中男6名,女5名,年齡47～79(61.45±7.90)歲；社區2型糖尿病腎病患者56例,其中男31例,女25例,年齡45～75(60.98±6.96)歲,均應用99Tcm-DTPA腎動態顯像測定GFR.分彆取註藥後第2分鐘和第3分鐘圖像勾畫ROI,根據Gates分析方法,計算總腎及分腎GFR.利用SPSS 15.0軟件對數據進行Pearson相關分析和兩樣本t檢驗.結果 2型糖尿病腎病患者的GFR與SCr[(84.90±14.38) μnol/L]呈負相關:註射99Tcm-DTPA後第2分鐘雙腎、左腎和右腎GFR均與SCr呈負相關(r=-0.599、-0.553和-0.529,均P＜0.001)；第3分鐘雙腎、左腎和右腎GFR也均與SCr呈負相關(r=-0.652、-0.636和-0.470,均P≤0.001).2型糖尿病腎病患者雙腎、左腎和右腎第3分鐘GFR分彆為(69.77±11.00)、(33.12±5.74)和(37.34±9.81) ml/min,低于健康對照組[(97.89±5.98)、(46.60±4.91)和(51.28±4.20) ml/min；t=-8.212、-7.233和-4.069,均P＜0.001].結論 建議對2型糖尿病腎病患者選擇註射99Tcm-DTPA後第3分鐘的放射性計數測定GFR;GFR測定對糖尿病腎病患者腎功能異常早期診斷具有重要意義.
목적 탐토2형당뇨병신병환자99Tcm-DTPA GFR측정적시간영향급GFR대2형당뇨병신공능이상조기진단적림상의의.방법 초모건강지원자11명,기중남6명,녀5명,년령47～79(61.45±7.90)세；사구2형당뇨병신병환자56례,기중남31례,녀25례,년령45～75(60.98±6.96)세,균응용99Tcm-DTPA신동태현상측정GFR.분별취주약후제2분종화제3분종도상구화ROI,근거Gates분석방법,계산총신급분신GFR.이용SPSS 15.0연건대수거진행Pearson상관분석화량양본t검험.결과 2형당뇨병신병환자적GFR여SCr[(84.90±14.38) μnol/L]정부상관:주사99Tcm-DTPA후제2분종쌍신、좌신화우신GFR균여SCr정부상관(r=-0.599、-0.553화-0.529,균P＜0.001)；제3분종쌍신、좌신화우신GFR야균여SCr정부상관(r=-0.652、-0.636화-0.470,균P≤0.001).2형당뇨병신병환자쌍신、좌신화우신제3분종GFR분별위(69.77±11.00)、(33.12±5.74)화(37.34±9.81) ml/min,저우건강대조조[(97.89±5.98)、(46.60±4.91)화(51.28±4.20) ml/min；t=-8.212、-7.233화-4.069,균P＜0.001].결론 건의대2형당뇨병신병환자선택주사99Tcm-DTPA후제3분종적방사성계수측정GFR;GFR측정대당뇨병신병환자신공능이상조기진단구유중요의의.
Objective To study the changes of GFR measured in different time intervals after the injection of 99Tcm-DTPA and to evaluate the clinical value of GFR in patients with type 2 diabetes.Methods Eleven healthy volunteers (6 males,5 females; mean age (61.45±7.90) years,age range:47-79 years)and 56 patients with type 2 diabetes (31 males,25 females; mean age (60.98±6.96) years,age range:45-75 years) were recruited.99Tcm-DTPA was used to measure GFR for all subjects.ROI was drawn at 2 and 3 min post-injection and GFR was calculated by Gates method.Two-sample t test and Pearson correlation analysis were performed with SPSS 15.0.Results SCr ((84.90±14.38) μmol/L) was significantly correlated with GFR in patients with type 2 diabetes.There was negative correlation between SCr and GFR for both,left and right kidneys at 3 min post-injection (r=-0.652,-0.636,-0.470,all P≤0.001) and at 2 min post-injection (r=-0.599,-0.553,-0.529,all P＜0.001).Total GFR,GFR for left kidney and GFR for right kidney at 3 min post-injection in diabetes group ((69.77 ± 11.00),(33.12 ± 5.74),(37.34 ± 9.81) ml/min) were lower than those in control group ((97.89±5.98),(46.60±4.91),(51.28±4.20) ml/min ; t =-8.212,-7.233,-4.069,all P＜0.001).Conclusions To calculate the GFR of the patients with type 2 diabetes,3 min post-injection is the optimal time.Measurement of GFR by 99Tcm-DTPA is useful in early diagnosis of diabetic nephropathy.
